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ProhibitedBinding ruleGBOriginal is EnglishOfficial-source import checked

Imazamox (ISO); (RS)-2-(4-isopropyl-4- methyl- 5-oxo-2-imidazolin-2-yl)-5- methoxymethylnicotinic acid

The consolidated GB Cosmetics Regulation lists this record in Annex II.

All Great Britain recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The consolidated GB Cosmetics Regulation lists this record in Annex II.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Imazamox (ISO); (RS)-2-(4-isopropyl-4- methyl- 5-oxo-2-imidazolin-2-yl)-5- methoxymethylnicotinic acid
CAS
114311-32-9
EC
Not supplied in this source row
Identity mapping
standalone:official_gb_annex
Search this identity across the siteCAS 114311-32-9

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

5 market datasets
PubChem 2D chemical structure for CAS 114311-32-9
CAS 114311-32-9PubChem CID 86137

Verified chemistry for CAS 114311-32-9

Imazamox

IUPAC name
5-(methoxymethyl)-2-(4-methyl-5-oxo-4-propan-2-yl-1H-imidazol-2-yl)pyridine-3-carboxylic acid
Molecular formula
C15H19N3O4
Molecular weight
305.33 g/mol
Exact mass
305.13755610 Da
Monoisotopic mass
305.13755610 Da
XLogP3
0.9
Topological polar surface area
101.0 Ų
Molecular complexity
491.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Rotatable bonds
5
Heavy atoms
22
Covalent units
1

Names and synonyms reported to PubChem

PulsarRaptorRaptor (herbicide)(+-)-ImazamoxUG6793ON5FAC 299263CL 299263SWEEPER 70DG
16 more reported names
AC-299263CL-2992632-(4,5-Dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl)-5-(methoxymethyl)-3-pyridinecarboxylic acid2-[4,5-Dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-(methoxymethyl)-3-pyridinecarboxylic acid3-Pyridinecarboxylic acid, 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-(methoxymethyl)-5-Methoxymethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid3-Pyridinecarboxylic acid, 2-(4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl)-5-(methoxymethyl)-5-(methoxymethyl)-2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]pyridine-3-carboxylic acid5-(methoxymethyl)-2-(4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl)pyridine-3-carboxylic acidRefChem:790602CHEBI:81857Imazamox [ISO]CL29926;(+/-)-ImazamoxHSDB 7013UNII-UG6793ON5FEINECS Annex I Index 613-208-00-7
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
10
3D rings
2
3D hydrophobes
1
3D acceptor features
5
3D donor features
1
3D anionic centres
1
3D cationic centres
0
3D conformers
10
Effective 3D rotors
5.4
Machine-readable structure identifiers
SMILES
CC(C)C1(C(=O)NC(=N1)C2=C(C=C(C=N2)COC)C(=O)O)C
InChI
InChI=1S/C15H19N3O4/c1-8(2)15(3)14(21)17-12(18-15)11-10(13(19)20)5-9(6-16-11)7-22-4/h5-6,8H,7H2,1-4H3,(H,19,20)(H,17,18,21)
InChIKey
NUPJIGQFXCQJBK-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match86137

Attributed physical-property, hazard, environmental and use annotations.

  • Toxicity Summary: IDENTIFICATION AND USE: Imazamox is off-white powdered solid. It is a herbicide applied post-emergence in soybean. HUMAN STUDIES: In an in vitro study, human embryonic stem cells were treated with imazamox at a concentration of 0, 1, 10 or 100 umol/L, incubation did not induce cytotoxicity. ANIMAL STUDIES: In the acute toxicity studies, the substance has low acute toxicity when administered orally, dermally or by inhalation to rats. It is not a significant skin or eye irritant or a skin sensitizer. Imazamox showed no short-term and long-term toxicity after oral exposure to rats, mice and dogs up to the limit top dose level tested in each study. Based on available genotoxicity studies imazamox is unlikely to be genotoxic. The substance showed no carcinogenic potential in both species. In the multigeneration toxicity study, fertility and overall reproductive performance was not impaired. In developmental toxicity studies maternal toxicity in rats and in rabbits was observed. No developmental toxicity was observed in rats whereas agenesis of the intermediate lobe of lung and cervical hemivertebra was observed in rabbits. ECOTOXICITY STUDIES: Imazamox is practically nontoxic to avian s Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Imazamox concentrations in whole and edible bluegill fish tissue were below the quantification limit, and the BCF for inedible tissue was less than 1X the concentration tested(1). An estimated BCF of 3.2 was calculated in fish for imazamox(SRC), using a log Kow of 0.73(2) and a regression-derived equation(3). According to a classification scheme(4), this BCF data suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values ranging from 5 to 143(2) indicate that imazamox is expected to have very high mobility in soil(SRC). The pKa values of imazamox have been reported as 2.3, 3.3 and 10.8(3), indicating that this compound will exist entirely in anion form in the environment and anions generally do not adsorb as strongly to soils containing organic carbon and clay as their neutral counterparts(4). Volatilization of imazamox is not expected to be an important fate process(SRC) because this chemical expected to exist as an anion in the environment and anions do not volatilize. Imazamox is primarily degraded by microbes in soil under aerobic conditions(2,3); essentially no degradation occurs under anaerobic conditions(2). Imazamox is considered moderately persistent with half-lives ranging between 15 to 142 days(2,3); its limited persistence will restrict leaching of imazamox into groundwater(2). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: In a field study with 5 soils, terrestrial dissipation half-lives ranged between 15 and 130 days(1). Leaching was found to be very limited in field studies(2). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values ranging from 5 to 143(2) indicate that imazamox is not expected to adsorb to suspended solids and sediment(SRC). The pKa values of imazamox have been reported as 2.3, 3.3 and 10.8(3) indicating imazamox will exist entirely in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(4), an estimated BCF of 3.2(SRC), from its log Kow of 0.73(5) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Photodegradation can be rapid with a half-life of 6.8 hours observed in laboratory studies(2,3); this rate is only applicable at the surface of the water with rates decreasing with water depth. Imazamox is stable to hydrolysis at pH 5, 7 and 9(2). Imazamox is considered moderately persistent in soil with half-lives ranging between 15 to 142 days(2,3). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), imazamox, which has an estimated vapor pressure of 1.26X10-11 mm Hg at 25 °C determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase imazamox may be removed from the air by wet and dry deposition(SRC). Imazamox photolytically decays with reported half-lives of 6.8 hours (or 0.3 days)(5,6) and 78 minutes (or 3 days)(7) for primary degradation in aqueous media. Direct aqueous photolysis results in several stable degradates(7). Photolysis in soil is a slower process with a half-life of 65 days(6). The rate of photodegradation decreases in the presence of Cu(II) and Ca(II) salts which form stable complexes with imazamox(7). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
Source reference
GB Cosmetics Regulation, Annex II, entry 1696
Source record ID
II-1696
Source version
2026-08-15
Source language
English
Translation status
Original is English
Effective date
2026-08-15
Source updated
2026-08-19
Snapshot checked
2026-08-30 04:51 UTC
Validation method
legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8

Registered dataset notes

Dataset coverage
Complete consolidated GB Annexes II–VI, with later amendments versioned separately
Authority note
Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Source licence
Open Government Licence v3.0 / Crown copyright
Attribution
Contains public sector information licensed under the Open Government Licence v3.0.
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2329
current Great Britain records
1758
records marked Prohibited
2329
records from this source version
2015
market records with CAS identity

Status distribution

Permitted list with conditions: 245Prohibited: 1758Restricted: 326

Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Great Britain market context

Complete consolidated annex dataset

Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Current consolidated Annexes II–VI for England, Scotland and Wales.

Verification checklist

  1. Confirm INCI/CAS/EC identity.
  2. Review every current GB Annex II–VI match.
  3. Check commencement dates and later statutory instruments.
  4. Verify SCPN, responsible-person, safety-report and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Imazamox (ISO); (RS)-2-(4-isopropyl-4- methyl- 5-oxo-2-imidazolin-2-yl)-5- methoxymethylnicotinic acid” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm INCI/CAS/EC identity.
  3. Review every current GB Annex II–VI match.
  4. Check commencement dates and later statutory instruments.
  5. Verify SCPN, responsible-person, safety-report and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

The record cites GB Cosmetics Regulation, Annex II, entry 1696, source version 2026-08-15. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Imazamox (ISO); (RS)-2-(4-isopropyl-4- methyl- 5-oxo-2-imidazolin-2-yl)-5- methoxymethylnicotinic acid. GB Cosmetics Regulation, Annex II, entry 1696. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/6051/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Great Britain

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-08-15
  • Effective date: 2026-08-15

What it does not prove

No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source