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胆碱的盐类及它们的酯类,包括氯化胆 碱、菲诺贝特胆碱、胆碱水杨 酸盐、 胆碱葡萄糖酸盐、胆茶碱、硬脂酸等长 链烷烃羧酸胆碱酯; 不包括卵磷脂、 甘油磷酸胆碱、氢化溶血卵磷酸酯酰胆 碱、氢化卵磷酰 胆碱、卵磷酰胆碱类; 其他相关原料需经安全风险评估方可 确定 — Choline salts and their esters, including choline chloride （INN） （CAS No. 67-48-1）, choline fenofibrate （CAS No. 856676-23-8）, choline salicylate （CAS No. 2016-36-6）, choline gluconate （CAS No. 507-30-2）, choline theophylline （CAS No. 4499-40-5）, choline esters of stearic acid and other long alkyl chain carboxylic acids; excluding lecithin （CAS No. 93685-90-6）, glycerophosphocholine （CAS No. 28319-77-9）, hydrogenated lysophosphatidylcholine （CAS No. 9008-30-4）, hydrogenated phosphatidylcholine（CAS No. 97281-48-6）, phosphatidylcholine （CAS No. 8002-43-5）; the usage of other relevant ingredients requires safety assessment

Choline salts and their esters, including choline chloride （INN） （CAS No. 67-48-1）, choline fenofibrate （CAS No. 856676-23-8）, choline salicylate （CAS No. 2016-36-6）, choline gluconate （CAS No. 507-30-2）, choline theophylline （CAS No. 4499-40-5）, choline

The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.

All China recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
Conditions and restrictions
Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

Substance identity

Official source name
胆碱的盐类及它们的酯类,包括氯化胆 碱、菲诺贝特胆碱、胆碱水杨 酸盐、 胆碱葡萄糖酸盐、胆茶碱、硬脂酸等长 链烷烃羧酸胆碱酯; 不包括卵磷脂、 甘油磷酸胆碱、氢化溶血卵磷酸酯酰胆 碱、氢化卵磷酰 胆碱、卵磷酰胆碱类; 其他相关原料需经安全风险评估方可 确定 — Choline salts and their esters, including choline chloride （INN） （CAS No. 67-48-1）, choline fenofibrate （CAS No. 856676-23-8）, choline salicylate （CAS No. 2016-36-6）, choline gluconate （CAS No. 507-30-2）, choline theophylline （CAS No. 4499-40-5）, choline esters of stearic acid and other long alkyl chain carboxylic acids; excluding lecithin （CAS No. 93685-90-6）, glycerophosphocholine （CAS No. 28319-77-9）, hydrogenated lysophosphatidylcholine （CAS No. 9008-30-4）, hydrogenated phosphatidylcholine（CAS No. 97281-48-6）, phosphatidylcholine （CAS No. 8002-43-5）; the usage of other relevant ingredients requires safety assessment
CAS
67-48-1; 856676-23-8; 2016-36-6; 507-30-2; 4499-40-5; 93685-90-6; 28319-77-9; 9008-30-4; 97281-48-6; 8002-43-5
EC
200-655-4
Identity mapping
cas_number
Linked ingredient
CHOLINE CHLORIDE
Search this identity across the siteCAS 67-48-1CAS 856676-23-8CAS 2016-36-6CAS 507-30-2CAS 4499-40-5CAS 93685-90-6CAS 28319-77-9CAS 9008-30-4CAS 97281-48-6CAS 8002-43-5EC 200-655-4

Linked CosIng identity data

Names and aliases

CHOLINE CHLORIDE

EU inventory restriction note: II/168

Recorded cosmetic function: HUMECTANT, SKIN CONDITIONING

Function pages:HUMECTANT, SKIN CONDITIONING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 2016-36-6
CAS 2016-36-6PubChem CID 54686350

Verified chemistry for CAS 2016-36-6

Choline Salicylate

IUPAC name
2-carboxyphenolate;2-hydroxyethyl(trimethyl)azanium
Molecular formula
C12H19NO4
Molecular weight
241.28 g/mol
Exact mass
241.13140809 Da
Monoisotopic mass
241.13140809 Da
Topological polar surface area
80.6 Ų
Molecular complexity
179.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Rotatable bonds
3
Heavy atoms
17
Covalent units
2

Names and synonyms reported to PubChem

Choline salicylic acid saltSalicylic acid choline saltCholine, salicylate (salt)Salicilato de colinaSalicylate de cholineSalicylic acid, ion(1-), cholineCholini salicylascholine subsalicylate
16 more reported names
KD510K1IQWEthanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 2-hydroxybenzoic acid (1:1)(2-hydroxyethyl)trimethylazanium 2-hydroxybenzoateEthanaminium, 2-hydroxy-N,N,N-trimethyl-, 2-hydroxybenzoate (1:1)MundasalDinnefordsRefChem:576083N02BA03217-948-8(2-Hydroxyethyl)trimethylammonium salicylateSyrap2-hydroxy-N,N,N-trimethylethanaminium 2-hydroxybenzoateArthropanActasalArtrobioneMundisal
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C[N+](C)(C)CCO.C1=CC=C(C(=C1)C(=O)O)[O-]
InChI
InChI=1S/C7H6O3.C5H14NO/c8-6-4-2-1-3-5(6)7(9)10;1-6(2,3)4-5-7/h1-4,8H,(H,9,10);7H,4-5H2,1-3H3/q;+1/p-1
InChIKey
UDKCHVLMFQVBAA-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 28319-77-9
CAS 28319-77-9PubChem CID 657272

Verified chemistry for CAS 28319-77-9

Choline Alfoscerate

IUPAC name
[(2R)-2,3-dihydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
Molecular formula
C8H20NO6P
Molecular weight
257.22 g/mol
Exact mass
257.10282436 Da
Monoisotopic mass
257.10282436 Da
XLogP3
-2.3
Topological polar surface area
99.1 Ų
Molecular complexity
233.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Rotatable bonds
8
Heavy atoms
16
Covalent units
1

Names and synonyms reported to PubChem

SN-glycero-3-phosphocholineCholine glycerophosphateL-alpha-GlycerophosphorylcholineGlycerophosphorylcholineL-alpha-GlycerophosphocholineCholine AlphoscerateGPChoCholini glycerophosphas
16 more reported names
Cholini alfoscerasGlicerofosfato de colinaalpha-GlycerophosphorylcholineAlfoscerato de colinaGlycerophosphate de cholineAlfoscerate de cholinealpha-GlycerylphosphorylcholineGlycerol phosphorylcholineSn-3-GPCglycerol-3-phosphocholineGlycerol-3-phosphatidylcholineGliatilinCHEBI:1687060M22SGW66(2R)-2,3-dihydroxypropyl 2-(trimethylammonio)ethyl phosphateL-1-glycero-3-phosphocholine
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
1
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
0
3D hydrophobes
0
3D acceptor features
4
3D donor features
2
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
8.0
Machine-readable structure identifiers
SMILES
C[N+](C)(C)CCOP(=O)([O-])OC[C@@H](CO)O
InChI
InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/m1/s1
InChIKey
SUHOQUVVVLNYQR-MRVPVSSYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 4499-40-5
CAS 4499-40-5PubChem CID 656652

Verified chemistry for CAS 4499-40-5

Oxtriphylline

IUPAC name
1,3-dimethyl-2-oxopurin-6-olate;2-hydroxyethyl(trimethyl)azanium
Molecular formula
C12H21N5O3
Molecular weight
283.33 g/mol
Exact mass
283.16443955 Da
Monoisotopic mass
283.16443955 Da
Topological polar surface area
91.6 Ų
Molecular complexity
415.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
4
Rotatable bonds
2
Heavy atoms
20
Covalent units
2

Names and synonyms reported to PubChem

Choline theophyllinateCholinophyllinCholine theophyllineCholedylTheocolinTeofilinato de colinaTheophyllinate de cholineCholine salt with theophylline (1:1)
16 more reported names
Oxtriphylline [USP]NSC-760431Choline theophyllinate [INN]3K045XR58XOxtriphylline (USP)Choline theophylline (JAN)Choline theophyllinate (INN)CholinophyllineOxtrimethyllineSoliphyllineTeofilcolinaTheoxyllineCholegylCHOLINE THEOPHYLLINE [JAN]FiloralSabidal
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CN1C(=C2C(=NC=N2)N(C1=O)C)[O-].C[N+](C)(C)CCO
InChI
InChI=1S/C7H8N4O2.C5H14NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-6(2,3)4-5-7/h3,12H,1-2H3;7H,4-5H2,1-3H3/q;+1/p-1
InChIKey
SOELXOBIIIBLRJ-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 507-30-2
CAS 507-30-2PubChem CID 20055440

Verified chemistry for CAS 507-30-2

Choline Gluconate

IUPAC name
2-hydroxyethyl(trimethyl)azanium;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
Molecular formula
C11H25NO8
Molecular weight
299.32 g/mol
Exact mass
299.15801676 Da
Monoisotopic mass
299.15801676 Da
Topological polar surface area
162.0 Ų
Molecular complexity
211.0
Formal charge
0
Hydrogen-bond donors
6
Hydrogen-bond acceptors
8
Rotatable bonds
6
Heavy atoms
20
Covalent units
2

Names and synonyms reported to PubChem

Choline gluconate [INN]CHOLINE D-GLUCONATEUNII-2M607MGJ8Ugluconato de colinagluconate de choline2M607MGJ8U(2-Hydroxyethyl)trimethylammonium D-gluconateacide gluconique
5 more reported names
cholini gluconascolina gluconatoRefChem:125753gluconate choline2-Hydroxy-N,N,N-trimethylethan-1-aminium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
4
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C[N+](C)(C)CCO.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O
InChI
InChI=1S/C6H12O7.C5H14NO/c7-1-2(8)3(9)4(10)5(11)6(12)13;1-6(2,3)4-5-7/h2-5,7-11H,1H2,(H,12,13);7H,4-5H2,1-3H3/q;+1/p-1/t2-,3-,4+,5-;/m1./s1
InChIKey
UJWRGESBUBDIIB-JJKGCWMISA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 67-48-1
CAS 67-48-1PubChem CID 6209

Verified chemistry for CAS 67-48-1

Choline Chloride

Choline chloride is a quaternary ammonium salt with choline cation and chloride anion. It has a role as an animal growth promotant. It is a chloride salt and a quaternary ammonium salt. It contains a choline. — ChEBI

IUPAC name
2-hydroxyethyl(trimethyl)azanium chloride
Molecular formula
C5H14ClNO
Molecular weight
139.62 g/mol
Exact mass
139.0763918 Da
Monoisotopic mass
139.0763918 Da
Topological polar surface area
20.2 Ų
Molecular complexity
46.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Rotatable bonds
2
Heavy atoms
8
Covalent units
2

Names and synonyms reported to PubChem

LipotrilHepacholineParesan2-Hydroxy-N,N,N-trimethylethanaminium chloride(2-Hydroxyethyl)trimethylammonium chlorideHormoclineBiocolinaLuridin chloride
16 more reported names
Choline hydrochlorideNeocolinaBilineurin chlorideBiocolineCholinium chlorideCholine, chlorideChloride de cholineCholine chlorhydrateCholini chloridumCloruro de colinaChlorure de cholineColina cloruroTrimethyl(2-hydroxyethyl)ammonium chlorideEthanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride(beta-Hydroxyethyl)trimethylammonium chlorideNSC-402838
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
C[N+](C)(C)CCO.[Cl-]
InChI
InChI=1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
InChIKey
SGMZJAMFUVOLNK-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 856676-23-8
CAS 856676-23-8PubChem CID 11350701

Verified chemistry for CAS 856676-23-8

Choline Fenofibrate

IUPAC name
2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate;2-hydroxyethyl(trimethyl)azanium
Molecular formula
C22H28ClNO5
Molecular weight
421.9 g/mol
Exact mass
421.1656007 Da
Monoisotopic mass
421.1656007 Da
Topological polar surface area
86.7 Ų
Molecular complexity
446.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
5
Rotatable bonds
6
Heavy atoms
29
Covalent units
2

Names and synonyms reported to PubChem

UNII-4BMH7IZT982-Hydroxy-N,N,N-trimethylethanaminium 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoateFenofibrate de cholineFenofibric acid choline salt4BMH7IZT98cholini fenofibratumfenofibrato de colinaHIP0901
16 more reported names
CHOLINE FENOFIBRATE (USP-RS)2-Hydroxy-N,N,N-trimethylethanaminium 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoateCHOLINE FENOFIBRATE (MART.)CHOLINE FENOFIBRATE [MART.]CHOLINE FENOFIBRATE [USP-RS]RefChem:54817Fenofibric AcidDelayed-ReleaseC10AB11ETHANAMINIUM, 2-HYDROXY-N,N,N-TRIMETHYL-, SALT WITH 2-(4-(4-CHLOROBENZOYL)PHENOXY)-2-METHYLPROPANOIC ACID (1:1)TrilipixABT-335ABT 335Choline Fenofibrate;ABT-335Choline fenofibrate (USAN/INN)CHOLINE FENOFIBRATE [WHO-DD]Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate (1:1)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CC(C)(C(=O)[O-])OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl.C[N+](C)(C)CCO
InChI
InChI=1S/C17H15ClO4.C5H14NO/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11;1-6(2,3)4-5-7/h3-10H,1-2H3,(H,20,21);7H,4-5H2,1-3H3/q;+1/p-1
InChIKey
JWAZHODZSADEHB-UHFFFAOYSA-M

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 9008-30-4
CAS 9008-30-4PubChem CID 5311264

Verified chemistry for CAS 9008-30-4

Lysophosphatidylcholines

IUPAC name
[(2R)-3-acetyloxy-2-hydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
Molecular formula
C10H22NO7P
Molecular weight
299.26 g/mol
Exact mass
299.11338904 Da
Monoisotopic mass
299.11338904 Da
XLogP3
-1.8
Topological polar surface area
105.0 Ų
Molecular complexity
320.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
7
Rotatable bonds
10
Heavy atoms
19
Covalent units
1

Names and synonyms reported to PubChem

LysophosphatidylcholineLysophosphatidylcholine, soybeanCHEBI:60479Lysolecithins((2R)-3-acetyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate((2R)-3-acetyloxy-2-hydroxypropyl) 2-trimethylazaniumylethyl phosphate[(2R)-3-acetyloxy-2-hydroxypropyl] 2-trimethylazaniumylethyl phosphateRefChem:389099
16 more reported names
SOLEC 8160232-715-0((2R)-2-hydroxy-3-tetradecanoyloxypropyl) 2-(trimethylazaniumyl)ethyl phosphate1-acetyl-sn-glycero-3-phosphocholineUNII-CQD833204ZEINECS 232-715-0C10H22NO7PEpitope ID:1367933-sn-LysophosphatidylcholineLysophosphatidylcholines (egg)GTPL2508CHEBI:138424RYCNUMLMNKHWPZ-SNVBAGLBSA-NLysophosphatidylcholine (for injection)DA-65168L-|A-Lysophosphatidylcholine, From Egg Yolk
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
1
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
0
3D hydrophobes
0
3D acceptor features
4
3D donor features
1
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
10.0
Machine-readable structure identifiers
SMILES
CC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)O
InChI
InChI=1S/C10H22NO7P/c1-9(12)16-7-10(13)8-18-19(14,15)17-6-5-11(2,3)4/h10,13H,5-8H2,1-4H3/t10-/m1/s1
InChIKey
RYCNUMLMNKHWPZ-SNVBAGLBSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 93685-90-6
CAS 93685-90-6PubChem CID 57369748

Verified chemistry for CAS 93685-90-6

Egg yolk phosphatidylcholines

IUPAC name
(2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate
Molecular formula
C35H66NO7P
Molecular weight
643.9 g/mol
Exact mass
643.45769044 Da
Monoisotopic mass
643.45769044 Da
XLogP3
9.1
Topological polar surface area
102.0 Ų
Molecular complexity
814.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
7
Rotatable bonds
32
Heavy atoms
44
Covalent units
1

Names and synonyms reported to PubChem

VitellinYokuretopauda LPJQWAHKMIYCERGA-UHFFFAOYSA-NDA-63129
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
2
3D conformers
0
Machine-readable structure identifiers
SMILES
CCCCCCCCC(=O)OC(COC(=O)CCCCCCCC=CCC=CCCCCC)COP(=O)(CC[N+](C)(C)C)[O-]
InChI
InChI=1S/C35H66NO7P/c1-6-8-10-12-14-15-16-17-18-19-20-21-22-24-25-27-34(37)41-31-33(32-42-44(39,40)30-29-36(3,4)5)43-35(38)28-26-23-13-11-9-7-2/h14-15,17-18,33H,6-13,16,19-32H2,1-5H3
InChIKey
JQWAHKMIYCERGA-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 97281-48-6
CAS 97281-48-6PubChem CID 65146

Verified chemistry for CAS 97281-48-6

Distearoylphosphatidylcholine

IUPAC name
2,3-di(octadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
Molecular formula
C44H88NO8P
Molecular weight
790.1 g/mol
Exact mass
789.62475576 Da
Monoisotopic mass
789.62475576 Da
XLogP3
15.6
Topological polar surface area
111.0 Ų
Molecular complexity
888.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
8
Rotatable bonds
44
Heavy atoms
54
Covalent units
1

Names and synonyms reported to PubChem

1,2-Distearoyllecithin4539-70-2DioctadecanoyllecithinDistearoyl-DL-phosphatidylcholine1,2-DistearoylphosphatidylcholineDioctadecanoyl phosphatidylcholineEAG959U9714-Hydroxy-N,N,N-trimethyl-10-oxo-7-((1-oxooctadecyl)oxy)-3,5,9-trioxa-4-phosphahepta cosan-1-aminium hydroxide, inner salt, 4-oxide
16 more reported names
(2-((2,3-bis(octadecanoyloxy)propyl phosphonato)oxy)ethyl)trimethylazanium(2-{[2,3-bis(octadecanoyloxy)propyl phosphonato]oxy}ethyl)trimethylazaniumDL-DSPCRefChem:72037distearoylglycerophosphocholine1,2-distearoyllecithin, (+-)-1,2-Distearoyl-rac-glycero-3-phosphocholine816-93-32,3-Bis(stearoyloxy)propyl (2-(trimethylammonio)ethyl) phosphateLecithindistearoylDL-beta,gamma-Distearoyl-alpha-lecithinHydro Soy PC3,5,9-Trioxa-4-phosphaheptacosan-1-aminium,4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxooctadecyl)oxy]-, inner salt,4-oxide, (7R)-1,2-DSPCStearoylLecithinUNII-EAG959U971
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
1
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D conformers
0
Machine-readable structure identifiers
SMILES
CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
InChI
InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3
InChIKey
NRJAVPSFFCBXDT-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
China NMPA banned raw-material catalogues (2021)
Source reference
NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 410
Source record ID
chemical-410
Source version
NMPA Announcement No. 74 of 2021, effective 2021-05-26
Source language
Chinese with source English/Latin identity
Translation status
Official English translation · English translation
Effective date
2021-05-26
Source updated
2021-05-26
Snapshot checked
2026-08-31 14:13 UTC
Validation method
pdfplumber tables; exact 1,284 + 109 row counts and contiguous source numbering
SHA-256
8848aa3e0c7ac5e74f56fc27927336c4fc2e5bc80137da087c2ca9ba2d2c075e

Registered dataset notes

Dataset coverage
All 1,284 banned raw materials and 109 banned plant/animal raw materials effective from 26 May 2021
Authority note
Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1393
current China records
1393
records marked Prohibited
1393
records from this source version
1249
market records with CAS identity

Status distribution

Prohibited: 1393

Condition text is present on 1393 of 1393 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

China market context

Complete prohibited catalogues plus official-source workflow

Coverage version: NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

All 1,284 banned raw materials and 109 banned plant/animal raw materials, plus the official workflow for the dynamic existing-ingredient inventory, other technical restrictions and new ingredients.

Verification checklist

  1. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  2. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  3. Review technical purpose, use history and any monitoring period.
  4. Confirm Chinese labelling, safety assessment and filing/registration duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “胆碱的盐类及它们的酯类,包括氯化胆 碱、菲诺贝特胆碱、胆碱水杨 酸盐、 胆碱葡萄糖酸盐、胆茶碱、硬脂酸等长 链烷烃羧酸胆碱酯; 不包括卵磷脂、 甘油磷酸胆碱、氢化溶血卵磷酸酯酰胆 碱、氢化卵磷酰 胆碱、卵磷酰胆碱类; 其他相关原料需经安全风险评估方可 确定 — Choline salts and their esters, including choline chloride （INN） （CAS No. 67-48-1）, choline fenofibrate （CAS No. 856676-23-8）, choline salicylate （CAS No. 2016-36-6）, choline gluconate （CAS No. 507-30-2）, choline theophylline （CAS No. 4499-40-5）, choline esters of stearic acid and other long alkyl chain carboxylic acids; excluding lecithin （CAS No. 93685-90-6）, glycerophosphocholine （CAS No. 28319-77-9）, hydrogenated lysophosphatidylcholine （CAS No. 9008-30-4）, hydrogenated phosphatidylcholine（CAS No. 97281-48-6）, phosphatidylcholine （CAS No. 8002-43-5）; the usage of other relevant ingredients requires safety assessment” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search the current NMPA IECIC List I and List II by Chinese name and identity.
  3. Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
  4. Review technical purpose, use history and any monitoring period.
  5. Confirm Chinese labelling, safety assessment and filing/registration duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

The record cites NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 410, source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

胆碱的盐类及它们的酯类,包括氯化胆 碱、菲诺贝特胆碱、胆碱水杨 酸盐、 胆碱葡萄糖酸盐、胆茶碱、硬脂酸等长 链烷烃羧酸胆碱酯; 不包括卵磷脂、 甘油磷酸胆碱、氢化溶血卵磷酸酯酰胆 碱、氢化卵磷酰 胆碱、卵磷酰胆碱类; 其他相关原料需经安全风险评估方可 确定 — Choline salts and their esters, including choline chloride （INN） （CAS No. 67-48-1）, choline fenofibrate （CAS No. 856676-23-8）, choline salicylate （CAS No. 2016-36-6）, choline gluconate （CAS No. 507-30-2）, choline theophylline （CAS No. 4499-40-5）, choline esters of stearic acid and other long alkyl chain carboxylic acids; excluding lecithin （CAS No. 93685-90-6）, glycerophosphocholine （CAS No. 28319-77-9）, hydrogenated lysophosphatidylcholine （CAS No. 9008-30-4）, hydrogenated phosphatidylcholine（CAS No. 97281-48-6）, phosphatidylcholine （CAS No. 8002-43-5）; the usage of other relevant ingredients requires safety assessment. NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 410. China. Source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. CosIng Checker regulatory record: https://cosingchecker.com/regulations/cn/records/12099/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for China

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: NMPA Announcement No. 74 of 2021, effective 2021-05-26
  • Effective date: 2021-05-26

What it does not prove

IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source