3-羟基-4-（（2-羟基萘基）偶氮）-7- 硝基萘-1-磺酸及其盐类 — 3-Hydroxy-4-（（2-hydroxynaphthyl）azo） -7-nitronaphthalene-1-sulfonic acid and its salts （CAS No. 16279-54-2 / CAS No 5610-64-0）
3-Hydroxy-4-（（2-hydroxynaphthyl）azo） -7-nitronaphthalene-1-sulfonic acid and its salts （CAS No. 16279-54-2 / CAS No 5610-64-0）
The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- The NMPA binding 2021 catalogue prohibits this raw material in cosmetic formulas in China.
- Conditions and restrictions
- Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.
Substance identity
- Official source name
- 3-羟基-4-（（2-羟基萘基）偶氮）-7- 硝基萘-1-磺酸及其盐类 — 3-Hydroxy-4-（（2-hydroxynaphthyl）azo） -7-nitronaphthalene-1-sulfonic acid and its salts （CAS No. 16279-54-2 / CAS No 5610-64-0）
- CAS
- 16279-54-2; 5610-64-0
- EC
- 227-029-3
- Identity mapping
- cas_number
- Linked ingredient
- ACID BLACK 52
Linked CosIng identity data
Names and aliases
CosIng description: Chromium, 3-hydroxy-4-[(2-hydroxy-1-naphthalenyl)azo]-7-nitro-1-naphthalenesulphonic acid complex (CI 15711)
EU inventory restriction note: II/1323
Recorded cosmetic function: HAIR DYEING
Function pages:HAIR DYEING
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordGreat Britain
1 linked record
Open supporting recordNew Zealand
2 linked records
Open supporting recordASEAN
1 linked record
Open supporting recordChina
Current record1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
1 linked record · 1 with specific conditions
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 16279-54-2
3-Hydroxy-4-((2-hydroxynaphthyl)azo)-7-nitronaphthalene-1-sulphonic acid
- IUPAC name
- 3-hydroxy-4-[(2-hydroxynaphthalen-1-yl)diazenyl]-7-nitronaphthalene-1-sulfonic acid
- Molecular formula
- C20H13N3O7S
- Molecular weight
- 439.4 g/mol
- Exact mass
- 439.04742094 Da
- Monoisotopic mass
- 439.04742094 Da
- XLogP3
- 4.1
- Topological polar surface area
- 174.0 Ų
- Molecular complexity
- 796.0
- Formal charge
- 0
- Hydrogen-bond donors
- 3
- Hydrogen-bond acceptors
- 9
- Rotatable bonds
- 3
- Heavy atoms
- 31
- Covalent units
- 1
Names and synonyms reported to PubChem
13 more reported names
External database identifiers
- ChEMBL:CHEMBL2008674
- EPA DTXSID:DTXSID5066031
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 13
- 3D rings
- 4
- 3D hydrophobes
- 0
- 3D acceptor features
- 5
- 3D donor features
- 2
- 3D anionic centres
- 2
- 3D cationic centres
- 0
- 3D conformers
- 6
- Effective 3D rotors
- 4.0
Machine-readable structure identifiers
- SMILES
C1=CC=C2C(=C1)C=CC(=C2N=NC3=C4C=CC(=CC4=C(C=C3O)S(=O)(=O)O)[N+](=O)[O-])O- InChI
InChI=1S/C20H13N3O7S/c24-16-8-5-11-3-1-2-4-13(11)19(16)21-22-20-14-7-6-12(23(26)27)9-15(14)18(10-17(20)25)31(28,29)30/h1-10,24-25H,(H,28,29,30)- InChIKey
SXYCCJAPZKHOLS-UHFFFAOYSA-N
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 5610-64-0
Acid Black 52
- IUPAC name
- trisodium;bis(chromium(3+));tris(7-nitro-3-oxido-4-[(2-oxidonaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate)
- Molecular formula
- C60H30Cr2N9Na3O21S3
- Molecular weight
- 1482.1 g/mol
- Exact mass
- 1480.922155 Da
- Monoisotopic mass
- 1480.922155 Da
- Topological polar surface area
- 547.0 Ų
- Molecular complexity
- 782.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 27
- Rotatable bonds
- 6
- Heavy atoms
- 98
- Covalent units
- 8
Names and synonyms reported to PubChem
11 more reported names
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
C1=CC=C2C(=C1)C=CC(=C2N=NC3=C4C=CC(=CC4=C(C=C3[O-])S(=O)(=O)[O-])[N+](=O)[O-])[O-].C1=CC=C2C(=C1)C=CC(=C2N=NC3=C4C=CC(=CC4=C(C=C3[O-])S(=O)(=O)[O-])[N+](=O)[O-])[O-].C1=CC=C2C(=C1)C=CC(=C2N=NC3=C4C=CC(=CC4=C(C=C3[O-])S(=O)(=O)[O-])[N+](=O)[O-])[O-].[Na+].[Na+].[Na+].[Cr+3].[Cr+3]- InChI
InChI=1S/3C20H13N3O7S.2Cr.3Na/c3*24-16-8-5-11-3-1-2-4-13(11)19(16)21-22-20-14-7-6-12(23(26)27)9-15(14)18(10-17(20)25)31(28,29)30;;;;;/h3*1-10,24-25H,(H,28,29,30);;;;;/q;;;2*+3;3*+1/p-9- InChIKey
OCDKNPOQLLEKKZ-UHFFFAOYSA-E
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- China NMPA banned raw-material catalogues (2021)
- Source reference
- NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 167
- Source record ID
chemical-167- Source version
- NMPA Announcement No. 74 of 2021, effective 2021-05-26
- Source language
- Chinese with source English/Latin identity
- Translation status
- Official English translation · English translation
- Effective date
- 2021-05-26
- Source updated
- 2021-05-26
- Snapshot checked
- 2026-08-31 14:13 UTC
- Validation method
- pdfplumber tables; exact 1,284 + 109 row counts and contiguous source numbering
- SHA-256
8848aa3e0c7ac5e74f56fc27927336c4fc2e5bc80137da087c2ca9ba2d2c075e
Registered dataset notes
- Dataset coverage
- All 1,284 banned raw materials and 109 banned plant/animal raw materials effective from 26 May 2021
- Authority note
- Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
How this record fits the market dataset
Status distribution
Condition text is present on 1393 of 1393 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
China market context
Complete prohibited catalogues plus official-source workflow
Coverage version: NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
All 1,284 banned raw materials and 109 banned plant/animal raw materials, plus the official workflow for the dynamic existing-ingredient inventory, other technical restrictions and new ingredients.
Verification checklist
- Search the current NMPA IECIC List I and List II by Chinese name and identity.
- Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
- Review technical purpose, use history and any monitoring period.
- Confirm Chinese labelling, safety assessment and filing/registration duties.
Official market sources
- China NMPA IECIC dynamic inventoryOfficial NMPA inventory, not a blanket permission or safety decision
- China draft mandatory cosmetic safety standardConsultation draft — not current law and not a substitute for the effective NMPA catalogues
- China NMPA banned raw-material catalogues (2021)Binding NMPA catalogues replacing Tables 1 and 2 of the 2015 Technical Specification
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “3-羟基-4-（（2-羟基萘基）偶氮）-7- 硝基萘-1-磺酸及其盐类 — 3-Hydroxy-4-（（2-hydroxynaphthyl）azo） -7-nitronaphthalene-1-sulfonic acid and its salts （CAS No. 16279-54-2 / CAS No 5610-64-0）” and every CAS/EC identifier refer to the material in your supplier specification.
- Search the current NMPA IECIC List I and List II by Chinese name and identity.
- Check prohibited/restricted and positive lists in the current Safety and Technical Standards.
- Review technical purpose, use history and any monitoring period.
- Confirm Chinese labelling, safety assessment and filing/registration duties.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECAvailable
- Separate condition textAvailable
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
3-羟基-4-（（2-羟基萘基）偶氮）-7- 硝基萘-1-磺酸及其盐类 — 3-Hydroxy-4-（（2-hydroxynaphthyl）azo） -7-nitronaphthalene-1-sulfonic acid and its salts （CAS No. 16279-54-2 / CAS No 5610-64-0）. NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 167. China. Source version NMPA Announcement No. 74 of 2021, effective 2021-05-26. CosIng Checker regulatory record: https://cosingchecker.com/regulations/cn/records/11856/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for China
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: NMPA Announcement No. 74 of 2021, effective 2021-05-26
- Effective date: 2021-05-26
What it does not prove
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source