Urea (carbamide) peroxide
Canada Hotlist: Urea (carbamide) peroxide
Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.
Regulatory decision and full conditions
- Status
- Restricted
- Legal role
- Official guidance
- Regulatory summary
- Health Canada lists this ingredient as restricted; the listed conditions and warnings apply.
- Conditions and restrictions
- See " Peroxide and peroxide-generating compounds ".
Substance identity
- Official source name
- Urea (carbamide) peroxide
- CAS
- 124-43-6
- EC
- 204-701-4
- Identity mapping
- cas_number
- Linked ingredient
- UREA PEROXIDE
Linked CosIng identity data
Names and aliases
CosIng description: Hydrogen peroxide-urea
EU inventory restriction note: III/12
Recorded cosmetic function: OXIDISING
Function pages:OXIDISING
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record · 1 with specific conditions
Open supporting recordCanada
Current record2 linked records · 2 with specific conditions
Open supporting recordVerified chemistry for CAS 124-43-6
Carbamide Peroxide
Urea hydrogen peroxide is a mixture obtained by combining equimolar amounts of hydrogen peroxide and urea. It has a role as a reagent, a disinfectant and an oxidising agent. It contains a urea and a hydrogen peroxide. — ChEBI
- IUPAC name
- hydrogen peroxide;urea
- Molecular formula
- CH6N2O3
- Molecular weight
- 94.07 g/mol
- Exact mass
- 94.03784206 Da
- Monoisotopic mass
- 94.03784206 Da
- Topological polar surface area
- 110.0 Ų
- Molecular complexity
- 29.0
- Formal charge
- 0
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 3
- Rotatable bonds
- 0
- Heavy atoms
- 6
- Covalent units
- 2
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:75178
- ChEMBL:CHEMBL3184026
- EPA DTXSID:DTXSID9024726
- PubMed:25254197
- PubMed:22666835
- PubMed:22031060
- PubMed:15527615
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
C(=O)(N)N.OO- InChI
InChI=1S/CH4N2O.H2O2/c2-1(3)4;1-2/h(H4,2,3,4);1-2H- InChIKey
AQLJVWUFPCUVLO-UHFFFAOYSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: greater than 680 °F (USCG, 1999) Source: CAMEO Chemicals
- Density: 0.8 at 68 °F (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.8 @ 20°C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: 167 to 185 °F (decomposes) (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: 75-85 Source: DrugBank
- Physical Description: Urea hydrogen peroxide appears as a solid or paste-like semisolid. Used to make plastics. Source: CAMEO Chemicals
- Physical Description: White solid; [Merck Index] Solid or paste-like semisolid; [CAMEO] Odorless; [CHRIS] White tablet; [Sigma-Aldrich MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: greater than or equal to 100 mg/mL at 68 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: 500 g/L at °C Source: DrugBank
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- ERG2024, Guide 140 (Urea hydrogen peroxide): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H272 (94.9%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H314 (83.1%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H315 (16.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (18.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P220, P260, P264, P264+P265, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P332+P317, P362+P364, P363, P370+P378, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 59 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: NITE-CMC
- Precautionary Statement Codes: P210, P220, P264, P264+P265, P280, P302+P352, P305+P354+P338, P317, P321, P332+P317, P362+P364, P370+P378, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: NITE-CMC
- Precautionary Statement Codes: P210, P220, P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P363, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Sources/Uses: Used as an antiseptic, cerumenolytic, and dental bleach; [Merck Index] Used to make plastics; [CAMEO] Used for hair bleaching, oxidation of permanent waves, and hair relaxing; [ExPub: EC: SCCP] Used to develop blueprints and for the modification of starches; [NTP] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Using Disinfectants or Biocides [Category: Clean]; Dressing Hair [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- Health Canada Cosmetic Ingredient Hotlist
- Source reference
- Hotlist restricted entry 88
- Source record ID
restricted:88- Source version
- Health Canada Hotlist 2025-08-13
- Source language
- English
- Translation status
- Original is English
- Source updated
- 2025-08-13
- Snapshot checked
- 2026-08-30 04:07 UTC
- Validation method
- strict HTML tables t1=490 and t2=90
- SHA-256
8b52ff573d08373ee90121f6a701b3607e4a3d6fc748a7d56171eb53510af91a
Registered dataset notes
- Dataset coverage
- Administrative prohibitions, restrictions, conditions and warning requirements
- Authority note
- Official Health Canada compliance indicator; not a complete safety clearance
How this record fits the market dataset
Status distribution
Condition text is present on 172 of 580 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
Canada market context
Complete Hotlist snapshot
Coverage version: Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
All prohibited and restricted Hotlist entries, including conditions and warning requirements published in the official list.
Verification checklist
- Search English/French names and CAS identifiers.
- Apply every restriction, concentration and label warning.
- Check Food and Drugs Act/Cosmetic Regulations requirements.
- Recheck the current Hotlist before notification or sale.
Official market sources
- Health Canada Cosmetic Ingredient HotlistOfficial Health Canada compliance indicator; not a complete safety clearance
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Urea (carbamide) peroxide” and every CAS/EC identifier refer to the material in your supplier specification.
- Search English/French names and CAS identifiers.
- Apply every restriction, concentration and label warning.
- Check Food and Drugs Act/Cosmetic Regulations requirements.
- Recheck the current Hotlist before notification or sale.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECAvailable
- Separate condition textAvailable
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
Urea (carbamide) peroxide. Hotlist restricted entry 88. Canada. Source version Health Canada Hotlist 2025-08-13. CosIng Checker regulatory record: https://cosingchecker.com/regulations/ca/records/578/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for Canada
This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.
Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.
How to interpret the legal role
The authority uses this source as compliance guidance; the underlying legislation remains controlling.
Evidence on this page
- Recorded outcome: Restricted
- Legal role: Official guidance
- Source version: Health Canada Hotlist 2025-08-13
What it does not prove
The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source