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ProhibitedBinding ruleBROfficial English translationOfficial-source import checked

Dinitrotolueno, qualidade técnica

ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.

All Brazil recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
ANVISA lists this substance among materials that may not be used in personal-hygiene products, cosmetics or perfumes in Brazil.
Conditions and restrictions
Dinitrotolueno, qualidade técnica

Substance identity

Official source name
Dinitrotolueno, qualidade técnica
CAS
121-14-2; 25321-14-6
EC
204-450-0; 246-836-1
Identity mapping
standalone:official_anvisa_record
Search this identity across the siteCAS 121-14-2CAS 25321-14-6EC 204-450-0EC 246-836-1

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 121-14-2
CAS 121-14-2PubChem CID 8461

Verified chemistry for CAS 121-14-2

2,4-Dinitrotoluene

IUPAC name
1-methyl-2,4-dinitrobenzene
Molecular formula
C7H6N2O4
Molecular weight
182.13 g/mol
Exact mass
182.03275668 Da
Monoisotopic mass
182.03275668 Da
XLogP3
2.0
Topological polar surface area
91.6 Ų
Molecular complexity
220.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Rotatable bonds
0
Heavy atoms
13
Covalent units
1

Names and synonyms reported to PubChem

2,4-Dinitrotoluol2,4-DNTBenzene, 1-methyl-2,4-dinitro-2,4-DinitromethylbenzeneToluene, 2,4-dinitro-2,4-Dinitro-1-methylbenzene4-Methyl-1,3-dinitrobenzeneNCI-C01865
16 more reported names
6-Methyl-1,3-dinitrobenzeneNSC-71946741D310EDCHEBI:920RefChem:443843204-450-0RCRA waste number U105NSC 71942,4-Dinitrotoluene, practical gradeBenzene, 1-methyl-2,4-dinitro-, sulfurized1326-41-6DNTEINECS 215-422-22,4-Dinitrotoluene (containing 0.5% 2,6-dinitrotoluene)2,4-Dinitrotoluene (containing 1.0-1.5% 2,6-dinitrotoluene)2,-Dinitrotoluene
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
1
3D hydrophobes
0
3D acceptor features
4
3D donor features
0
3D anionic centres
2
3D cationic centres
0
3D conformers
1
Effective 3D rotors
2.0
Machine-readable structure identifiers
SMILES
CC1=C(C=C(C=C1)[N+](=O)[O-])[N+](=O)[O-]
InChI
InChI=1S/C7H6N2O4/c1-5-2-3-6(8(10)11)4-7(5)9(12)13/h2-4H,1H3
InChIKey
RMBFBMJGBANMMK-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8461

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H361f ***: Suspected of damaging fertility [Warning Reproductive toxicity]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P318, P319, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301+H311+H331 (26.7%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]; H301+H311 (37%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]; H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (98.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H330 (38.4%): Fatal if inhaled [Danger Acute toxicity, inhalation]; H331 (61.6%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H341 (99.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (99.3%): May cause cancer [Danger Carcinogenicity]; H361 (49.5%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H361f (50.5%): Suspected of damaging fertility [Warning Reproductive toxicity]; H373 (99.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400 (98.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (98.6%): Very toxic to aquatic life with long lasting effects [Warning Hazardou Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P318, P319, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 281 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P271, P273, P280, P301+P316, P304+P340, P308+P316, P318, P319, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Health Effects: 2,4-Dinitrotoluene poisoning may cause methemoglobinemia, anemia, leukopenia, and liver necrosis. Liver injury may be more common than cyanosis. (T48, L276) Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 3 - Materials that in themselves are capable of detonation or explosive decomposition or explosive reaction but that require a strong initiating source or must be heated under confinement before initiation. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: 2,4-DNT may cause conversion of oxyhemoglobin to methemoglobin via oxidation of iron(II) to iron(III) by its metabolites. High levels of methemoglobin are removed by catabolism, leading to the development of anemia. Some metabolites of 2,4-DNT are also transported back from the bile to the liver, where the amine group is N-hydroxylated by cytochrome P-450 to form an unstable sulfate conjugate. The sulfate conjugate is degraded into carbonium or nitrenium ions. These ions covalently bind to hepatic macromolecules (DNA, RNA), leading to mutations and subsequently liver tumors. They also bind to DNA of the lung and the intestine. (L276, T45, A171, L280) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: Bioconcentration factor (weighted average) = 3.8 (calculated) for aquatic organisms that contain about 7.6% lipids. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 9 was calculated for 2,4-dinitrotoluene(SRC), using a log Kow of 1.98(1) and a regression-derived equation(2). The BCF for dinitrotoluene (mixed isomers) has been measured to be low (BCF values of 0.6 to 21.2) in carp (Carprinus carpio)(3). According to a classification scheme(4), these BCF values suggest the potential for bioconcentration in aquatic organisms is low. An experimental BCF of 204 (fat basis) was determined for 2,4-dinitrotoluene in the guppy (Poecilia reticulata)(5). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc range of 57-2000, determined from two adsorption studies(2,3), indicates that 2,4-dinitrotoluene can have high to low mobility in soil(SRC). Leaching of 2,4-dinitrotoluene has been observed in soil column transport studies(4) and it has been detected in groundwater samples beneath ammunition plants(5,6) indicating 2,4-dinitrotoluene can leach from soil. Volatilization of 2,4-dinitrotoluene from moist soil surfaces is not expected to be an important fate process(SRC) given a measured Henry's Law constant 5.4X10-8 atm-cu m/mole at 25 °C(7). 2,4-Dinitrotoluene is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.47X10-4 mm Hg(8). 2,4-Dinitrotoluene may undergo direct photolysis on soil surfaces, based on observed photolysis of 2,4-dinitrotoluene in water(9). Biodegradation of 2,4-dinitrotoluene is expected to be an important fate process in soil based on results of various screening tests that demonstrated microbial degradation(10-14). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc range of 57-2000, determined from two adsorption studies(2,3), indicates that 2,4-dinitrotoluene is expected to be susceptible to some adsorption to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(4) based upon a Henry's Law constant of 5.4X10-8 atm-cu m/mole at 25 °C(5). According to a classification scheme(6), an estimated BCF of 9(SRC), from its log Kow of 1.98(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low. Photolysis of 1.0 ppm 2,4-dinitrotoluene in distilled and natural waters gave half-lives of 43 hrs in distilled water and 2.7, 9.6, and 3.7 hrs in river, bay and pond waters, respectively(9). 2,4-Dinitrotoluene is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(4). Biodegradation of 2,4-dinitrotoluene is expected to be an important fate process in water based on results of various screening tests that demonstrated microbial degradation(10-14). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,4-dinitrotoluene, which has a vapor pressure of 1.47X10-4 mm Hg at 22 °C(2), is expected to exist solely as a vapor in the ambient atmosphere at 22 °C. However, at 15 °C, 2,4-dinitrotoluene has a vapor pressure of 6X10-5 mm Hg(3) which indicates it will exist in both the vapor and particulate phases in the ambient atmosphere. 2,4-Dinitrotoluene has been detected in atmospheric particulate matter(4). Vapor-phase 2,4-dinitrotoluene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 75 days(SRC), calculated from its rate constant of 2.2X10-13 cu cm/molecule-sec at 25 °C(SRC), determined using a structure estimation method(5). Particulate-phase 2,4-dinitrotoluene may be removed from the air by wet or dry deposition(SRC). 2,4-Dinitrotoluene is susceptible to direct photolysis in sunlight(6). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The predominant use of 2,4-dinitrotoluene is as an intermediate in the manufacture of polyurethanes. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used to make dyes, explosives, munitions, propellants, rubber chemicals, plastics, and other chemicals; [HSDB] The technical grade (approximately 80/20 of the 2,4/2,6 isomers) is used primarily as an intermediate for toluene diamines and diisocyanates; [IARC] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: 2,4-Dinitrotoluene is used by the munitions industry as a modifier for smokeless powders and, to a limited extent, as a gelatinizing and waterproofing agent in military and commercial explosive compositions. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Intermediate in the manufacture of toluene diisocyanate and polyurethanes. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Organic synthesis, toluidines. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Most of the 2,4-dinitrotoluene produced is hydrogenated to 2,4-diaminotoluene (m-tolylenediamine) for conversion to toluene diisocyanate (TDI), which is a component of a polyurethane; a much smaller amount is used in explosives and for further nitration to TNT. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: It is a high explosive and one of the precursors for trinitrotoluene (TNT), which is synthesized through three separate nitrations of toluene. 2,4-Dinitrotoluene can affect the body if it is inhaled, comes in contact with the eyes or skin, is swallowed, or is absorbed through the skin. Even a small amount absorbed from clothes or shoes may cause toxic symptoms. It is assumed that oral ingestion could be a secondary route for occupationally exposed humans. (L270, T44) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Brazil ANVISA consolidated prohibited substances — RDC 529/2021 through RDC 1.030/2026
Source reference
RDC 529/2021 consolidated annex, entry 687 (through RDC 1.030/2026)
Source record ID
annex:687
Source version
RDC 529/2021 consolidated through RDC 1.030/2026
Source language
Portuguese with official English identity where published
Translation status
Official English translation · English translation
Effective date
2026-06-15
Source updated
2026-06-15
Snapshot checked
2026-08-31 15:26 UTC
Validation method
pdfplumber government baseline + 4 RDC 1.030 exclusions + 15 additions; 1,387 substantive rows
SHA-256
a212e85540a186a842664fbdd4f351af0b1b4baeeb0c4765b9b52c6ce91c1e84

Registered dataset notes

Dataset coverage
All 1,387 substantive current prohibited rows after applying RDC 1.030/2026 additions, amendments and exclusions to RDC 529/2021
Authority note
Binding consolidated prohibited list for personal-hygiene products, cosmetics and perfumes
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1387
current Brazil records
1387
records marked Prohibited
1387
records from this source version
1335
market records with CAS identity

Status distribution

Prohibited: 1387

Condition text is present on 1387 of 1387 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Brazil market context

Complete prohibited dataset plus current restricted-list workflow

Coverage version: ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026

All 1,387 substantive current prohibited rows in RDC 529/2021 consolidated through RDC 1.030/2026, plus the current RDC 1.029 restricted-list and identity workflow.

Verification checklist

  1. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  2. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  3. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  4. Verify Mercosur incorporation, regularisation, labelling and transition periods.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Dinitrotolueno, qualidade técnica” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Resolve Portuguese, INCI and CAS identity with the ANVISA crosswalk.
  3. Check the consolidated prohibited list including RDC 1.030/2026 changes.
  4. Apply RDC 1.029/2026 restrictions and the still-effective complementary rules.
  5. Verify Mercosur incorporation, regularisation, labelling and transition periods.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

The record cites RDC 529/2021 consolidated annex, entry 687 (through RDC 1.030/2026), source version RDC 529/2021 consolidated through RDC 1.030/2026. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Dinitrotolueno, qualidade técnica. RDC 529/2021 consolidated annex, entry 687 (through RDC 1.030/2026). Brazil. Source version RDC 529/2021 consolidated through RDC 1.030/2026. CosIng Checker regulatory record: https://cosingchecker.com/regulations/br/records/13887/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Brazil

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: RDC 529/2021 consolidated through RDC 1.030/2026
  • Effective date: 2026-06-15

What it does not prove

RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source