ProhibitedBinding ruleASEANOriginal is EnglishOfficial-source import checked
Diboron trioxide; boric oxide
ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- Diboron trioxide; boric oxide
- CAS
- 1303-86-2
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_asean_record
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
Prohibited entry found
1 linked record
Open supporting recordGreat Britain
Prohibited
1 linked record
Open supporting recordNew Zealand
Prohibited
1 linked record
Open supporting recordASEAN
Current recordProhibited
1 linked record
Open supporting recordBrazil
Prohibited
1 linked record · 1 with specific conditions
Open supporting recordIndia
Prohibited
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
Prohibited
1 linked record
Open supporting recordCAS 1303-86-2PubChem CID 11073337
Verified chemistry for CAS 1303-86-2
Boron oxide (B2O3)
- IUPAC name
- 2,4,5-trioxa-1,3-diborabicyclo[1.1.1]pentane
- Molecular formula
- B2O3
- Molecular weight
- 69.63 g/mol
- Exact mass
- 70.0033542 Da
- Monoisotopic mass
- 70.0033542 Da
- Topological polar surface area
- 27.7 Ų
- Molecular complexity
- 33.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 3
- Rotatable bonds
- 0
- Heavy atoms
- 5
- Covalent units
- 1
Names and synonyms reported to PubChem
Boron sesquioxide483W67CPF4Boron OxydatumFused boric acidCaswell No. 109BBoric oxide (B2O3)RefChem:917472Boric acid (HBO2), anhydride
16 more reported names
CHEBI:35777215-125-8259-231-2620-845-4B2O3Boric anhydrideBoric oxideBoron oxideCHEBI:30163Diboron trioxideBORON OXIDE [MI]Boron oxide (99.6%-B)Boron oxide (99.9%-B)Boron oxide, (H2O 200ppm)Boron Oxide Powder, 98% NanoBoron oxide, Puratronic, (H2O 200ppm)
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D conformers
- 0
Machine-readable structure identifiers
- SMILES
B12OB(O1)O2- InChI
InChI=1S/B2O3/c3-1-4-2(3)5-1- InChIKey
RPPTVYMVSNHGRG-UHFFFAOYSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match11073337
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 3380 °F at 760 mmHg (NIOSH, 2024) Source: CAMEO Chemicals
- Boiling Point: 1500 °C (crystal) Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: ~1860 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 3380 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 1500 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Boiling Point: 3380 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Color/Form: Colorless, brittle, vitreous, semitransparent lumps or hard, white crystals Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Colorless, glassy or hexagonal crystals, hygroscopic Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Colorless powder or vitreous crystals Source: Hazardous Substances Data Bank (HSDB)
- Density: 2.46 (NIOSH, 2024) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 1.8 g/cu cm (amorphous); 2.46 g/cu cm (crystal) Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 2.46 (cryst) Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 2.46 Source: Occupational Safety and Health Administration (OSHA)
- Density: 2.46 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Density: 2.46 Source: The National Institute for Occupational Safety and Health (NIOSH)
- Melting Point: 842 °F (NIOSH, 2024) Source: CAMEO Chemicals
- Melting Point: 450 °C (crystal) Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 450 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: 842 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: 450 °C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: 842 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Odor: Odorless Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Boron oxide appears as colorless, semi-transparent glassy lumps or hard white odorless crystals. Mp 450 °C; bp: 1860 °C. Density: 2.46 g cm-3. Moderately soluble in water. Used as an insecticide; as the starting material for the synthesis of other boron compounds; as a fluxing agent in enamels and glasses; and in mixture with 2-6% boron nitride, as a bonding agent in the hot isostatic pressing of boron nitride ceramics. Source: CAMEO Chemicals
- Physical Description: Other Solid; Dry Powder; CBI; Large Crystals; Liquid; Other Solid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless, semitransparent lumps or hard, white, odorless crystals; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: WHITE HYGROSCOPIC POWDER OR GRANULES Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Colorless, semitransparent lumps or hard, white, odorless crystals. Source: Occupational Safety and Health Administration (OSHA)
- Physical Description: Colorless, semitransparent lumps or hard, white, odorless crystals. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Refractive Index: INDEX OF REFRACTION: 1.61 Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 3 % (NIOSH, 2024) Source: CAMEO Chemicals
- Solubility: Slowly soluble in 30 parts cold water; slowly soluble in 5 parts boiling water; soluble in alcohol, glycerol Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Water solubility: 4.0% at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 2.77 g/100 g water at 20 °C. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility in water, g/l at 25 °C: 36 (moderate) Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: 3% Source: The National Institute for Occupational Safety and Health (NIOSH)
- Vapor Pressure: 0 mmHg (approx) (NIOSH, 2024) Source: CAMEO Chemicals
- Vapor Pressure: Negligible at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 0 mmHg (approx) Source: Occupational Safety and Health Administration (OSHA)
- Vapor Pressure: 0 mmHg (approx) Source: The National Institute for Occupational Safety and Health (NIOSH)
- pH: pH = 5.1 at 20 °C 1.0% solution Source: Hazardous Substances Data Bank (HSDB)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: inhalation, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
- First Aid: Excerpt from NIOSH Pocket Guide for Boron oxide:; Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: WATER FLUSH PROMPTLY - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: FRESH AIR - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. Other measures are usually unnecessary.; Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024) Source: CAMEO Chemicals
- First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: Fresh air; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H360 (95.1%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H360FD (13.1%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 588 reports by companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity] Source: NITE-CMC
- Precautionary Statement Codes: P203, P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P318, P319, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: NITE-CMC
- Target Organs: Eyes, skin, respiratory system Source: The National Institute for Occupational Safety and Health (NIOSH)
- Consumer Uses: Other; Adhesion/cohesion promoter; Flame retardant; Not Known or Reasonably Ascertainable; Catalyst Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Not Known or Reasonably Ascertainable; Catalyst; Flux agent; Flame retardant; Hardener; Other; Processing aids not otherwise specified Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used to produce elemental boron, heat-resistant glass, fire-resistant paint, electronics, and herbicides; Derived by heating boric acid; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Semiconductor Manufacturing [Category: Industry]; Glass Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: For boron oxide (USEPA/OPP Pesticide Code: 011002) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
- Uses: Used in herbicides; fire resistant additive for paints, electronics; liquid encapsulation techniques Source: Hazardous Substances Data Bank (HSDB)
- Uses: In metallurgy; in analysis of silicates to determine silicon dioxide and alkalies; in blowpipe analysis. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Flux for enamels and glazes; additive for glass fibers; chemical intermediate for elemental boron, boron master alloys, borides, boron carbide, nitrides and halides Source: Hazardous Substances Data Bank (HSDB)
- Uses: As catalyst Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- ASEAN Cosmetic Directive annexes
- Source reference
- ASEAN Annex II, reference 1394
- Source record ID
II-1394- Source version
- 2026-1
- Source language
- English
- Translation status
- Original is English
- Source updated
- 2026-06-22
- Snapshot checked
- 2026-08-30 04:44 UTC
- Validation method
- pdfplumber ruled-table extraction with per-annex reviewed counts
- SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1
Registered dataset notes
- Dataset coverage
- Banned, restricted and positive-list substances under the harmonised ASEAN framework
- Authority note
- Regional directive; member-state transitions and deviations still require local verification
How this record fits the market dataset
2224
current ASEAN records
1728
records marked Prohibited
2224
records from this source version
1930
market records with CAS identity
Status distribution
Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
ASEAN market context
Complete regional annex dataset
Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.
Verification checklist
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
Official market sources
- ASEAN Cosmetic Directive annexesRegional directive; member-state transitions and deviations still require local verification
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “Diboron trioxide; boric oxide” and every CAS/EC identifier refer to the material in your supplier specification.
- Search all ACD annexes by name and identifiers.
- Apply product type, maximum level and warning conditions.
- Confirm the target member state's adoption and transition date.
- Complete the local notification and responsible-company requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textNot present in source row
- Effective dateNot supplied
- Snapshot hash and methodAvailable
Questions this page answers
This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
The record cites ASEAN Annex II, reference 1394, source version 2026-1. Open the official source.
No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.
Stable citation
Diboron trioxide; boric oxide. ASEAN Annex II, reference 1394. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/3533/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for ASEAN
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: 2026-1
What it does not prove
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source