CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
ProhibitedBinding ruleASEANOriginal is EnglishOfficial-source import checked

Heptachlor-epoxide

ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.

All ASEAN recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
ASEAN Annex II lists this record among substances prohibited in cosmetic products. Member-state transition rules and deviations still require local verification.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Heptachlor-epoxide
CAS
1024-57-3
EC
Not supplied in this source row
Identity mapping
standalone:official_asean_record
Search this identity across the siteCAS 1024-57-3

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

9 market datasets
PubChem 2D chemical structure for CAS 1024-57-3
CAS 1024-57-3PubChem CID 15559699

Verified chemistry for CAS 1024-57-3

Heptachlor Epoxide

Heptachlor Epoxide can cause cancer according to an independent committee of scientific and health experts. — California Office of Environmental Health Hazard Assessment (OEHHA)

IUPAC name
(1S,2R,3S,5S,6R,7S,8R)-1,6,8,9,10,11,11-heptachloro-4-oxatetracyclo[6.2.1.02,7.03,5]undec-9-ene
Molecular formula
C10H5Cl7O
Molecular weight
389.3 g/mol
Exact mass
387.813059 Da
Monoisotopic mass
385.816009 Da
XLogP3
3.7
Topological polar surface area
12.5 Ų
Molecular complexity
504.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Rotatable bonds
0
Heavy atoms
18
Covalent units
1

Names and synonyms reported to PubChem

EpoxyheptachlorVelsicol 53-CS-17055UWF6R6IENT 25,5841,4,5,6,7,8,8-Heptachloro-2,3-epoxy-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene1,4,5,6,7,8,8-Heptachloro-2,3-epoxy-3a,4,7,7a-tetrahydro-4,7-methanoindan2,5-Methano-2H-oxireno(a)indene, 2,3,4,5,6,7,7-heptachlor-1a,1b,5,5a,6,6a-hexahydro-2,5-Methano-2H-oxireno(a)indene, 2,3,4,5,6,7,7-heptachloro-1a,1b,5,5a,6,6a-hexahydro-
16 more reported names
4,7-Methanoindan, 1,4,5,6,7,8,8-heptachloro-2,3-epoxy-3a,4,7,7a-tetrahydro-2,5-Methano-2H-indeno(1,2-b)oxirene, 2,3,4,5,6,7,7-heptachloro-1a,1b,5,5a,6,6a-hexahydro-, (1aalpha,1bbeta,2alpha,5alpha,5abeta,6beta,6aalpha)-2,5-Methano-2H-indeno(1,2-b)oxirene, 2,3,4,5,6,7,7-heptachloro-1a,1b,5,5a,6,6a-hexahydro-,(1aR,1bS,2R,5S,5aR,6S,6aR)-rel-Epoxide, HeptachlorVelsicol 53CS17RefChem:7835831,6,8,9,10,11,11-heptachloro-4-oxatetracyclo(6.2.1.02,7.03,5)undec-9-ene213-831-0cis-Heptachlor Epoxiderel-(1aR,1bS,2R,5S,5aR,6S,6aR)-2,3,4,5,6,7,7-Heptachloro-1a,1b,5,5a,6,6a-hexahydro-2,5-methano-2H-indeno[1,2-b]oxirene(+/-)-cis-Heptachlor epoxideUNII-055UWF6R6ICCRIS 9452cis-Heptachlor-exo-epoxide (isomer B)HSDB 6182EINECS 213-831-0
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
7
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
3
3D rings
2
3D hydrophobes
0
3D acceptor features
1
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.6
Machine-readable structure identifiers
SMILES
[C@@H]12[C@@H]([C@H]([C@@H]3[C@H]1O3)Cl)[C@]4(C(=C([C@@]2(C4(Cl)Cl)Cl)Cl)Cl)Cl
InChI
InChI=1S/C10H5Cl7O/c11-3-1-2(4-5(3)18-4)9(15)7(13)6(12)8(1,14)10(9,16)17/h1-5H/t1-,2+,3+,4-,5+,8+,9-/m0/s1
InChIKey
ZXFXBSWRVIQKOD-UOFFAGTMSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:34786

Heptachlor epoxide

Formula
C10H5Cl7O
Average mass
389.320 g/mol
Monoisotopic mass
385.81601 Da
Formal charge
0
  • oxanes — is a (CHEBI:46942)
  • oxanes — is a (CHEBI:46942)
Additional curated names
Heptachlor epoxide
Cross-references from this source
  • CAS: 1024-57-3 — KEGG COMPOUND
  • MANUAL_X_REF: C14327 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-07-28. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match15559699

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P264, P270, P273, P280, P301+P316, P318, P319, P321, P330, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H300 (58.3%): Fatal if swallowed [Danger Acute toxicity, oral]; H301 (41.7%): Toxic if swallowed [Danger Acute toxicity, oral]; H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]; H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P264, P270, P273, P280, P301+P316, P318, P319, P321, P330, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 12 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H300: Fatal if swallowed [Danger Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P264, P270, P273, P280, P301+P316, P318, P319, P321, P330, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H300: Fatal if swallowed [Danger Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P264, P270, P280, P301+P316, P318, P319, P321, P330, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Toxicity Summary: Heptachlor epoxide is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overstimulation of the nervous system. Heptachlor epoxide is also believed to exert carcinogenic effects by activating key kinases in signalling pathways and inhibiting apoptosis. (L118, A81, A82) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: EIGHT PESTICIDES, INCLUDING HEPTACHLOR EPOXIDE, WERE BIOCONCENTRATED IN THE FAT OF CLAMS IMPLANTED IN CAGES ANCHORED TO THE BOTTOM OF THE KASKASKIA RIVER NEAR TUSCOLA, ILLINOIS OVER 72 DAYS. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: STUDY PLOTS WERE TREATED AT 0.56, 2.24, OR 8.97 KG ACTIVE INGREDIENT/HA WITH HEPTACHLOR. EARTHWORMS & SOILS WERE SAMPLED FROM EACH PLOT WHEN TREATED & 0.5 TO 24 MO THEREAFTER. IN SOILS & EARTHWORMS, HEPTACHLOR EPOXIDE INCREASED SIGNIFICANTLY DURING THE 2 YR STUDY. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: ... /IT PASSES/ THROUGH FOOD CHAINS & UNDERGOES BIOLOGIC MAGNIFICATION. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Heptachlor exhibits a tendency for bioaccumulation, with bioconcentration factors on the order of 1X10+4 for several organisms. ... /Heptachlor/ Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: The bioconcentration of heptachlor epoxide in freshwater clam (Corbicula manilensis) fat was 2330 as determined in a 72 day experiment(1). In fathead minnows the BCF was 14400 as determined in a 32 day test in a flow-through aquarium(2). The steady state BCF for sheepshead minnow (Cyprinodon variegatus), pinfish (Lagodon rhomboides), mussels (Mytilus edulis), and oyster (Crassostrea virginica) is 4500, 2900, 1700, and 851, respectively(3). In a 33 day model ecosystem, the BCF was 4900 in fish (Gambusia), 66000 in snail (Physa), and 1600 in alga (Oedogonium)(6). Based on the log octanol/water partition coefficient of 5.40(4), one would estimate a BCF of 7500 in fish using a recommended regression equation(5,SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: LABELED HEPTACHLOR WAS APPLIED TO ... SOIL. ANALYSES ... INDICATED PRESENCE OF 1-HYDROXYCHLORDENE, HEPTACHLOR EPOXIDE & A METABOLITE LESS HYDROPHILIC THAN HEPTACHLOR EPOXIDE. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Heptachlor epoxide adsorbs strongly to soil and is extemely resistant to biodegradation. Monitoring studies reveal that it persists for many years in soil and does not appear to leach significantly into the lower soil layers. On the soil surface, heptachlor epoxide may slowly photodegrade, particularly during the summer months (1% per month). Heptachlor epoxide loss from soil in a microagricultural chamber is observed after application, but the rate of loss decreases over the course of a few days. This loss may be due to volatilization or photolysis of the chemical from the surface microlayer. (SRC) Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: If released into water, heptachlor epoxide will adsorb strongly to suspended and bottom sediment. Little biodegradation would be expected and photolysis probably would only be significant in surface waters in the presence of photosensitizers. While slow volatilization of the free molecule (half-life 60 hr from a model river) would be expected, since heptachlor epoxide would be mainly adsorbed to particulate matter, this would not be a primary loss mechanism. No measureable degradation occurred when 10 ppb of heptachlor epoxide was incubated in water of the Little Miami River, a stream receiving domestic, industrial, and agricultural wastes, for 8 wks in sealed jars under sunlight and artificial lights(1). Heptachlor epoxide was very persistant in a model ecosystem, having approximately the same environmental stability as dieldrin(2). Its estimated half-life in the lower Rhine River based on concentration differences between sampling points was 35 days(3). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: Based upon the vapor pressure, heptachlor epoxide is expected to exist in both vapor and particulate phases in ambient air. In the atmosphere, vapor phases reactions with photochemically produced hydroxyl radicals may be an important fate process. The rate constant for the vapor-phase reaction of heptachlor epoxide with photochemically produced hydroxyl radicals has been estimated to be 1.09X10-11 cu cm/molecule-sec at 25 °C, which corresponds to an atmospheric half-life of about 1.5 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). Heptachlor epoxide that is associated with particulate matter and aerosols and should be subject to gravitational settling and washout by rain. Contamination of lakes with heptachlor epoxide is believed to occur primarily by wet deposition. Under the proper conditions, heptachlor epoxide bearing dust can be transported for thousands of miles. Photolysis would be expected to occur but there are no data on the extent of heptachlor epoxide degradation in dispersed dust and aerosols(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
ASEAN Cosmetic Directive annexes
Source reference
ASEAN Annex II, reference 994
Source record ID
II-994
Source version
2026-1
Source language
English
Translation status
Original is English
Source updated
2026-06-22
Snapshot checked
2026-08-30 04:44 UTC
Validation method
pdfplumber ruled-table extraction with per-annex reviewed counts
SHA-256
ffad59f6c01a92c82042c54203ee14969425c2a82bd04c2f4012ff82513e69f1

Registered dataset notes

Dataset coverage
Banned, restricted and positive-list substances under the harmonised ASEAN framework
Authority note
Regional directive; member-state transitions and deviations still require local verification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2224
current ASEAN records
1728
records marked Prohibited
2224
records from this source version
1930
market records with CAS identity

Status distribution

Permitted list with conditions: 247Prohibited: 1728Restricted: 249

Condition text is present on 462 of 2224 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

ASEAN market context

Complete regional annex dataset

Coverage version: ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

Annexes II, III, IV, VI and VII covering prohibited, restricted and positive-list substances.

Verification checklist

  1. Search all ACD annexes by name and identifiers.
  2. Apply product type, maximum level and warning conditions.
  3. Confirm the target member state's adoption and transition date.
  4. Complete the local notification and responsible-company requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Heptachlor-epoxide” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search all ACD annexes by name and identifiers.
  3. Apply product type, maximum level and warning conditions.
  4. Confirm the target member state's adoption and transition date.
  5. Complete the local notification and responsible-company requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

The record cites ASEAN Annex II, reference 994, source version 2026-1. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Heptachlor-epoxide. ASEAN Annex II, reference 994. ASEAN. Source version 2026-1. CosIng Checker regulatory record: https://cosingchecker.com/regulations/asean/records/3135/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for ASEAN

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-1

What it does not prove

Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source