Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
InventoryRef cosing-live-991272023-05-23

SPHINGOSINE 1-PHOSPHATE

Sphingosine 1-Phosphate is the phosphorylated sphingolipid that conforms to the formula:

SPHINGOSINE 1-PHOSPHATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI CheckerCompare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sourcesSearch every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 26993-30-6
CAS 26993-30-6PubChem CID 5283560

Sphingosine 1-Phosphate

Sphingosine 1-phosphate is a phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1. It has a role as a vasodilator agent, a signalling molecule, a sphingosine-1-phosphate receptor agonist, a T-cell proliferation inhibitor and a mouse metabolite. It is functionally related to a sphingosine. It is a conjugate acid of a sphingosine 1-phosphate(1-). — ChEBI

IUPAC name
[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate
Molecular formula
C18H38NO5P
Molecular weight
379.5 g/mol
Exact mass
379.24876031 Da
XLogP3
1.9
Topological polar surface area
113.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Covalent units
1
Defined stereocentres
2

Also known as

sphingosine-1-phosphateD-erythro-sphingosine 1-phosphateC18-Sphingosine 1-phosphate(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphateSphing-4-enine 1-phosphateSphing-4-enine-1-phosphateYVE187NJ1U4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-
16 more reported names
CHEBI:37550Sphingosine 1-phosphic acid(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(Dihydrogen phosphate)4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (R-(R*,S*-(E)))-(2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid((2S,3R)-2-amino-3-hydroxyoctadec-4-enyl) dihydrogen phosphate((E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl) dihydrogen phosphate[(2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), [R-[R*,S*-(E)]]-RefChem:8885084-Octadecene-1,3-Diol, 2-Amino-, 1-(Dihydrogen Phosphate), (2S,3R,4E)636-659-1D-erythro-Sphingosine-1-phosphateS1P(2S,3R,E)-2-Amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphateSphingosine-1-Phosphate (d18:1)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID
99127
Entry status
Active
Published in the Official Journal
Yes
Recorded by the Commission
2023-05-23
Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for SPHINGOSINE 1-PHOSPHATE

INCI name

SPHINGOSINE 1-PHOSPHATE

Description

Sphingosine 1-Phosphate is the phosphorylated sphingolipid that conforms to the formula:

Record provenance

Inventory reference
cosing-live-99127
Imported identity
SPHINGOSINE 1-PHOSPHATE
Source update
2023-05-23
European Commission CosIng source notes
Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search

Search annex entries

Search the annex database for entries matching SPHINGOSINE 1-PHOSPHATE or related substances.

Key data

CAS
26993-30-6
EC
—
Restriction
—
Function
SKIN CONDITIONING - HUMECTANT
Increasing the water content of the top layers of the skin. Humectants are primarily hygroscopic agents drawing moisture from the surrounding air.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#27419 · SPHINGOSINE 1-PHOSPHATE

Ingredients with overlapping formulation functions

SODIUM TAMARINDUS INDICA SEED GUM EXTRACTHAIR CONDITIONING; SKIN CONDITIONING - HUMECTANT
SOLANUM LYCOPERSICUM CALLUS CULTURE VESICLESSKIN CONDITIONING - HUMECTANT
SPENT GRAIN EXTRACTANTIOXIDANT; HAIR CONDITIONING; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT
SPHINGOMONAS OLEI FERMENT EXTRACT FILTRATESKIN CONDITIONING - HUMECTANT
SPICULISPORIC ACIDANTIMICROBIAL, EXFOLIATING, SKIN CONDITIONING - HUMECTANT, SURFACTANT - EMULSIFYING
SPIRAEA SALICIFOLIA EXTRACTHAIR CONDITIONING; HUMECTANT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT
SPONGILLA LACUSTRIS SPICULEHAIR CONDITIONING; HUMECTANT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT
SR-(ESCHERICHIA COLI THIOREDOXIN-1 HEPTAPEPTIDE-20 HEXAPEPTIDE-40 OLIGOPEPTIDE-…SKIN CONDITIONING - HUMECTANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How SPHINGOSINE 1-PHOSPHATE appears in the CosIng inventory

The CosIng inventory lists SPHINGOSINE 1-PHOSPHATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SPHINGOSINE 1-PHOSPHATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SPHINGOSINE 1-PHOSPHATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SPHINGOSINE 1-PHOSPHATE carries the following function designation(s):

CAS 26993-30-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Open INCI Checker

Source note for SPHINGOSINE 1-PHOSPHATE

This page reproduces the CosIng inventory entry for SPHINGOSINE 1-PHOSPHATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SPHINGOSINE 1-PHOSPHATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sourcesView updates

Tools & next steps

Check your formula

Scan a full INCI list to detect SPHINGOSINE 1-PHOSPHATE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to SPHINGOSINE 1-PHOSPHATE, its identifiers or nearby name variants.

Search