Is PRUNIN safe to use in EU cosmetics?

PRUNIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does PRUNIN serve in cosmetics?

According to the EU CosIng inventory, PRUNIN carries the following function designation(s): ANTIOXIDANT, SKIN PROTECTING, SKIN CONDITIONING - HUMECTANT.

What other records share CAS 529-55-5?

CAS 529-55-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PRUNIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-989172023-05-23

PRUNIN

Prunin is the product obtained by the reaction of Naringenin and Glucose. It conforms to the formula:

PRUNIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 529-55-5

CAS 529-55-5PubChem CID 92794

Prunin

Naringenin 7-O-beta-D-glucoside is a flavanone 7-O-beta-D-glucoside that is (S)-naringenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as a metabolite, an antibacterial agent, a hypoglycemic agent and an antilipemic drug. It is a flavanone 7-O-beta-D-glucoside, a member of 4'-hydroxyflavanones, a (2S)-flavan-4-one, a dihydroxyflavanone and a monosaccharide derivative. It is functionally related to a (S)-naringenin. — ChEBI

IUPAC name: (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3-dihydrochromen-4-one

Molecular formula: C21H22O10
Molecular weight: 434.4 g/mol
Exact mass: 434.12129689 Da
XLogP3: 0.6
Topological polar surface area: 166.0 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 10
Covalent units: 1
Defined stereocentres: 6

Also known as

Naringenin 7-O-beta-D-glucosidePRUNIN PROTEIN, PRUNUSLSB8HDX4E5Pru du 6 protein, PrunusCHEBI:28327(2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl beta-D-glucopyranosideNSC-135064(2S)-5-HYDROXY-2-(4-HYDROXYPHENYL)-7-((2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL)OXY-2,3-DIHYDROCHROMEN-4-ONE

16 more reported names

RefChem:870060(2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-(3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-2,3-dihydrochromen-4-one208-464-8(S)-7-(beta-D-Glucopyranosyloxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-oneAC-35062CS-0017098NARINGENIN 7-.BETA.-D-GLUCOSIDE, (-)-(S)-5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-oneSR-05000013703-1pruningNARINGENIN 7-GLUCOSIDEEINECS 208-464-8NSC 135064Pru1 protein, PrunusPru2 protein, Prunusnaringenin-7-glucoside

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28327
ChEMBL:CHEMBL469654
EPA DTXSID:DTXSID40967365
PubMed:31194956

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 98917
Entry status: Active
Published in the Official Journal: Yes
Recorded by the Commission: 2023-05-23

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for PRUNIN

INCI name

PRUNIN

Description

Prunin is the product obtained by the reaction of Naringenin and Glucose. It conforms to the formula:

Record provenance

Inventory reference: cosing-live-98917
Imported identity: PRUNIN
Source update: 2023-05-23

European Commission CosIng source notes

Annex records for PRUNIN

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Key data

CAS

529-55-5

208-464-8

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.
SKIN CONDITIONING - HUMECTANT: Increasing the water content of the top layers of the skin. Humectants are primarily hygroscopic agents drawing moisture from the surrounding air.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#23387 · PRUNIN

Ingredients with overlapping formulation functions

POTASSIUM ASCORBYLBORATESKIN CONDITIONING - HUMECTANT

POTASSIUM EDTA-PLATINUMANTIMICROBIAL; ANTIOXIDANT; SKIN CONDITIONING - HUMECTANT

POTASSIUM FRUCTOBORATESKIN CONDITIONING - HUMECTANT

POUTERIA CAIMITO FRUIT EXTRACTSKIN CONDITIONING - HUMECTANT

PSEUDOMONAS GUGUANENSIS EXTRACT FILTRATESKIN CONDITIONING - EMOLLIENT; SKIN CONDITIONING - HUMECTANT

PUNICA GRANATUM CALLUS EXTRACELLULAR VESICLESSKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - …

PUNICA GRANATUM FLOWER WATERSKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - MISCELLANEOUS

PUNICA GRANATUM PEEL WATERSKIN CONDITIONING - HUMECTANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PRUNIN appears in the CosIng inventory

The CosIng inventory lists PRUNIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PRUNIN is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PRUNIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PRUNIN carries the following function designation(s):

CAS 529-55-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PRUNIN

This page reproduces the CosIng inventory entry for PRUNIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PRUNIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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