Is NONOXYNOL-1 safe to use in EU cosmetics?

NONOXYNOL-1 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains NONOXYNOL-1?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1051882024-08-26

NONOXYNOL-1

Nonoxynol-1 is the ethoxylated alkyl phenol that conforms generally to the formula

NONOXYNOL-1 is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 27986-36-3

CAS 27986-36-3PubChem CID 171092

Nonylphenol monoethoxylate

IUPAC name: 2-(2-nonylphenoxy)ethanol

Molecular formula: C17H28O2
Molecular weight: 264.4 g/mol
Exact mass: 264.208930132 Da
XLogP3: 5.8
Topological polar surface area: 29.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

TericsEthanol, 2-(nonylphenoxy)-RefChem:891403248-762-52-(NONYLPHENOXY)ETHANOLEthanol,2-(nonylphenoxy)-93-32-32-(o-Nonylphenoxy)ethanol

13 more reported names

RN8NP35H6TEthanol, 2-(o-nonylphenoxy)-Ethanol, 2-(2-nonylphenoxy)-Nonylphenoxyglycolteric NEthylene glycol nonylphenyl ethermarlophen 89nonylphenolethoxylateEINECS 248-762-5UNII-RN8NP35H6Tnonylphenol ethoxyacetic acid2-(2-Nonylphenoxy)ethan-1-olIEORSVTYLWZQJQ-UHFFFAOYSA-N

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID10860056

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 37205-87-1

CAS 37205-87-1PubChem CID 92035818

Nonoxynol-1

The CIR Expert Panel concluded that the following 27 Nonoxynols listed below are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating..Nonoxynol-1... — Cosmetic Ingredient Review (CIR)

IUPAC name: 1-ethoxy-4-(7-methyloctyl)benzene

Molecular formula: C17H28O
Molecular weight: 248.4 g/mol
Exact mass: 248.214015512 Da
XLogP3: 6.6
Topological polar surface area: 9.2 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

Marlophen NP 6Marlophen NP 8Marlophen NP 10Marlophen NP 12Neonol AF 9Neonol AF 10Neonol AF9 10ANeonol AF9 12A

16 more reported names

Neonol AF 9-5Neonol AF 9-9Neonol AF 9-10Neonol AF 9-22Neonol AF 9-25Neonol AF 9-60MAF 12Nonoxynol5Nonoxynol6Nonoxynol10Nonoxynol11Nonoxynol12Nonoxynol20Nonoxynol23Nonoxynol35Nonoxynol40

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Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 105188
Entry status: Active
Published in the Official Journal: Yes
Recorded by the Commission: 2024-08-26

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for NONOXYNOL-1

INCI name

NONOXYNOL-1

Description

Nonoxynol-1 is the ethoxylated alkyl phenol that conforms generally to the formula

Record provenance

Inventory reference: cosing-live-105188
Imported identity: NONOXYNOL-1
Source update: 2024-08-26

European Commission CosIng source notes

Annex records for NONOXYNOL-1

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Key data

CAS

26027-38-3 (generic)/ 37205-87-1 (generic)/ 27986-36-3

-/ -/ 248-762-5

Restriction

—

Function

SURFACTANT - EMULSIFYING: Helping suspensions or dispersions of liquids in a second liquid by reducing the surface tension of the substances to be emulsified.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17554 · NONOXYNOL-1

Ingredients with overlapping formulation functions

MYRISTYLDIMONIUMHYDROXYPROPYL COCOGLUCOSIDES CHLORIDECLEANSING, SKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

N-OLEYL HYDROXYHEXANAMIDEEMULSION STABILISING, HAIR CONDITIONING, PRESERVATIVE, SKIN CONDITIONING, SURFACTANT - CLEANSING, S…

NEOPENTYL GLYCOL DIISOSTEARATESKIN CONDITIONING, SURFACTANT - EMULSIFYING

NEOPENTYL GLYCOL DILAURATESKIN CONDITIONING, SURFACTANT - EMULSIFYING

NONOXYNOL-10SURFACTANT - EMULSIFYING

NONOXYNOL-10 CARBOXYLIC ACIDSURFACTANT - EMULSIFYING

NONOXYNOL-10 PHOSPHATESURFACTANT - EMULSIFYING; SURFACTANT - HYDROTROPE; SURFACTANT - CLEANSING

NONOXYNOL-11SURFACTANT - EMULSIFYING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NONOXYNOL-1 appears in the CosIng inventory

The CosIng inventory lists NONOXYNOL-1 as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NONOXYNOL-1 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NONOXYNOL-1 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NONOXYNOL-1 carries the following function designation(s):

SURFACTANT - EMULSIFYING

CAS 26027-38-3 (generic)/ 37205-87-1 (generic)/ 27986-36-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NONOXYNOL-1

This page reproduces the CosIng inventory entry for NONOXYNOL-1 from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NONOXYNOL-1 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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