What does the restriction note for NAPHAZOLINE HCL mean?

The restriction field for NAPHAZOLINE HCL reads: II/244. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 550-99-2?

CAS 550-99-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains NAPHAZOLINE HCL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1051842026-07-24

NAPHAZOLINE HCL

Naphazoline HCL is the heterocyclic compound that conforms to the formula

NAPHAZOLINE HCL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet. Inventory note: II/244.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 550-99-2

CAS 550-99-2PubChem CID 11079

Naphazoline Hydrochloride

Naphazoline is an organic molecular entity. — ChEBI

IUPAC name: 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride

Molecular formula: C14H15ClN2
Molecular weight: 246.73 g/mol
Exact mass: 246.0923762 Da
Topological polar surface area: 24.4 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 1
Covalent units: 2
Defined stereocentres: 0

Also known as

NAPHAZOLINE HCLAlbalonVasoconOpconRhinantinRhinoperdStricylonNiazol

16 more reported names

Naphcon fortePrivine hydrochlorideNaphazoline chlorideColdanSanorinPrizole hydrochlorideNAFAZAIR2-(1-Naphthylmethyl)-2-imidazoline hydrochlorideNSC-357111H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, monohydrochloride2-Imidazoline, 2-(1-naphthylmethyl)-, monohydrochlorideNazalAntistin-privineNaphaz hclSato ClearGppe nsl soln

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External database identifiers

ChEBI:CHEBI:7470
ChEMBL:CHEMBL1706
EPA DTXSID:DTXSID7045788

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 105184
Entry status: Active
Published in the Official Journal: Yes
Recorded by the Commission: 2026-07-24

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for NAPHAZOLINE HCL

INCI name

NAPHAZOLINE HCL

Description

Naphazoline HCL is the heterocyclic compound that conforms to the formula

Record provenance

Inventory reference: cosing-live-105184
Imported identity: NAPHAZOLINE HCL
Source update: 2026-07-24

European Commission CosIng source notes

Annex records for NAPHAZOLINE HCL

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Key data

CAS

550-99-2

208-989-2

Restriction

II/244

Function

SKIN CONDITIONING - MISCELLANEOUS: Enhancing the appearance of dry and/or damaged skin by reducing flaking and restoring suppleness.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17223 · NAPHAZOLINE HCl

Ingredients with overlapping formulation functions

N-DECANOYL SERINOLANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN CONDITIONING - MISCELLANEOUS, S…

N-DECYL-N-METHYLBENZYLAMINEANTIOXIDANT; HAIR CONDITIONING; SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

N-DICHLOROACETYL TRYPTAMINEANTIOXIDANT; SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

N-DIMETHYLBENZAMIDE SERINOLANTIOXIDANT; HAIR CONDITIONING; SKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS

NARDOSTACHYS JATAMANSI ROOT EXTRACTSKIN CONDITIONING - MISCELLANEOUS

NELUMBO NUCIFERA LEAF VESICLESSKIN CONDITIONING - MISCELLANEOUS

NEOLITSEA SERICEA FRUIT EXTRACTANTIMICROBIAL; SKIN CONDITIONING - MISCELLANEOUS

NEOSETOPHOMA CEREALIS EXTRACTSKIN CONDITIONING - MISCELLANEOUS

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NAPHAZOLINE HCL appears in the CosIng inventory

The CosIng inventory lists NAPHAZOLINE HCL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NAPHAZOLINE HCL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NAPHAZOLINE HCL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

The restriction field for NAPHAZOLINE HCL reads: "II/244". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, NAPHAZOLINE HCL carries the following function designation(s):

SKIN CONDITIONING - MISCELLANEOUS

CAS 550-99-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NAPHAZOLINE HCL

This page reproduces the CosIng inventory entry for NAPHAZOLINE HCL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NAPHAZOLINE HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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