What function does CURCUMIN BIS-METHYL ETHER serve in cosmetics?

According to the EU CosIng inventory, CURCUMIN BIS-METHYL ETHER carries the following function designation(s): ANTI-SEBORRHEIC, ANTIOXIDANT, ANTI-SEBUM, COLORANT, HAIR CONDITIONING.

What other records share CAS 52328-98-0?

CAS 52328-98-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CURCUMIN BIS-METHYL ETHER?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1043122024-08-16

CURCUMIN BIS-METHYL ETHER

Curcumin Bis-Methyl Ether is the organic compound that conforms to the formula

CURCUMIN BIS-METHYL ETHER is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 52328-98-0

CAS 52328-98-0PubChem CID 6477182

Dimethylcurcumin

Dimethylcurcumin is a synthetic chemical compound that is loosely based on a compound found in curcumin. It is a novel anti-androgen that enhances androgen receptor degradation. — DrugBank

IUPAC name: (1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one

Molecular formula: C23H24O6
Molecular weight: 396.4 g/mol
Exact mass: 396.15728848 Da
XLogP3: 4.6
Topological polar surface area: 74.2 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

Go-Y025ASCJ-9GO-Y-025D60XLY608DCHC-0041,4,6-Heptatrien-3-one, 1,7-bis(3,4-dimethoxyphenyl)-5-hydroxy-, (Z,E,E)-1,4,6-Heptatrien-3-one, 1,7-bis(3,4-dimethoxyphenyl)-5-hydroxy-, (1E,4Z,6E)--RefChem:588527

16 more reported names

922-365-31,6-HEPTADIENE-3,5-DIONE, 1,7-BIS(3,4-DIMETHOXYPHENYL)-, (1E,6E)-ASC-J91,7-Bis-(3,4-dimethoxyphenyl)-5-hydroxy-hepta-1,4,6-trien-3-one(1E,4E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-oneEX-A9271,7-Bis-(3,4-dimethoxy-phenyl)-5-hydroxy-hepta-1,4,6-trien-3-oneDS-14720ASC-J9,CAS:52328-98-0(1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one(1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxy-hepta-1,4,6-trien-3-one(1E,4E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-oneASC-J9;GO-Y025CHC 004; Di-O-methylcurcuminUNII-D60XLY608D1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:233431
ChEMBL:CHEMBL128748
EPA DTXSID:DTXSID10200352
PubMed:20691508
PubMed:9767632
PubMed:1426

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 104312
Published in the Official Journal: Yes
Recorded by the Commission: 2024-08-16

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for CURCUMIN BIS-METHYL ETHER

INCI name

CURCUMIN BIS-METHYL ETHER

Description

Curcumin Bis-Methyl Ether is the organic compound that conforms to the formula

Record provenance

Inventory reference: cosing-live-104312
Imported identity: CURCUMIN BIS-METHYL ETHER
Source update: 2024-08-16

European Commission CosIng source notes

Annex records for CURCUMIN BIS-METHYL ETHER

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Key data

CAS

52328-98-0

—

Restriction

—

Function

ANTI-SEBORRHEIC: Preventing or relieving the symptoms of seborrhea and/or seborrheic dermatitis, including dandruff.
ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
ANTI-SEBUM: Helping control sebum production.
COLORANT: Exclusively or mainly intended to colour the cosmetic product, the body as a whole or certain parts thereof, by absorption or reflection of visible light. All authorised colorants are substances in the positive list of Annex IV to the Cosmetics Regulation 1223/2009.
HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#7783 · CURCUMIN BIS-METHYL ETHER

Ingredients with overlapping formulation functions

CLIMBAZOLEANTI-SEBORRHEIC, ANTIMICROBIAL, PRESERVATIVE

CLOTRIMAZOLEANTI-SEBORRHEIC, ANTIMICROBIAL

COAL TARANTI-SEBORRHEIC, ANTIMICROBIAL, DENATURANT

COPTIS JAPONICA EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, HAIR CONDITIONING, SKIN CONDITIONING

ENTEROCOCCUS FAECIUM/LACTOBACILLUS/SALIX PURPUREA BARK/LEAF/STEM/WOOD/ASCORBIC …ANTI-SEBORRHEIC, ANTIPLAQUE, HUMECTANT, SKIN CONDITIONING

ETHYL LAUROYL ARGINATE HCLANTI-SEBORRHEIC, HAIR CONDITIONING, PRESERVATIVE, SKIN CONDITIONING - MISCELLANEOUS

FRAGARIA ANANASSA SEED OILANTI-SEBORRHEIC, ANTIOXIDANT, HAIR CONDITIONING, NAIL CONDITIONING, SKIN CONDITIONING

GALENIA AFRICANA LEAF/STEM EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CURCUMIN BIS-METHYL ETHER appears in the CosIng inventory

The CosIng inventory lists CURCUMIN BIS-METHYL ETHER as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CURCUMIN BIS-METHYL ETHER is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CURCUMIN BIS-METHYL ETHER is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CURCUMIN BIS-METHYL ETHER carries the following function designation(s):

CAS 52328-98-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CURCUMIN BIS-METHYL ETHER

This page reproduces the CosIng inventory entry for CURCUMIN BIS-METHYL ETHER from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CURCUMIN BIS-METHYL ETHER and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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