What function does SR-HONEY BEE DEFENSIN-1 serve in cosmetics?

According to the EU CosIng inventory, SR-HONEY BEE DEFENSIN-1 carries the following function designation(s): ANTIMICROBIAL, SKIN PROTECTING, SKIN CONDITIONING - MISCELLANEOUS.

How do I check if my formula contains SR-HONEY BEE DEFENSIN-1?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1015272024-06-28

SR-HONEY BEE DEFENSIN-1

SR-HONEY BEE DEFENSIN-1 is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Exact external identity check

not_found

No complete-name PubChem match was verified. The material may be a mixture, trade-style INCI identity or be indexed under another identifier; this result must not be read as proof that no related chemistry exists.

Exact CosIng INCI name equals a PubChem synonym · Checked 2026-08-31

Official European Commission record

CosIng substance ID: 101527
Published in the Official Journal: Yes
Recorded by the Commission: 2024-06-28

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for SR-HONEY BEE DEFENSIN-1

INCI name

SR-HONEY BEE DEFENSIN-1

Description

sr-Honey Bee Defensin-1 is a single chain recombinant protein produced by fermentation in E. coli. The starting gene is synthesized to be identical to the gene which codes for Defensin-1 derived from the honey bee, Apil mellifera. The parent protein contains a maximum of 95 amino acids which may contain disulfide bonds and/or glycosylation and consists of the proper sequence of the 20 standard amino acids.

Record provenance

Inventory reference: cosing-live-101527
Imported identity: SR-HONEY BEE DEFENSIN-1
Source update: 2024-06-28

European Commission CosIng source notes

Annex records for SR-HONEY BEE DEFENSIN-1

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Key data

CAS

—

The CosIng inventory records no CAS number for this ingredient. That is the absence of an identifier in the source, not a finding about the substance.

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Restriction

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Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.
SKIN CONDITIONING - MISCELLANEOUS: Enhancing the appearance of dry and/or damaged skin by reducing flaking and restoring suppleness.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#27628 · sr-HONEY BEE DEFENSIN-1

Ingredients with overlapping formulation functions

SR-(METHIONYL SH-POLYPEPTIDE-131 DIPEPTIDE-19 HEXAPEPTIDE-40)ANTIMICROBIAL, SKIN PROTECTING

SR-(METHIONYL TRIPEPTIDE-46 HEXAPEPTIDE-40 DIPEPTIDE-69 ESCHERICHIA COLI POLYPE…ANTIMICROBIAL

SR-(SH-POLYPEPTIDE-140 SH-POLYPEPTIDE-141 SH-POLYPEPTIDE-142)ANTIMICROBIAL

SR-(SH-POLYPEPTIDE-143 SH-POLYPEPTIDE-144)ANTIMICROBIAL

SR-MOUSE POLYPEPTIDE-5ANTIMICROBIAL; SKIN CONDITIONING - MISCELLANEOUS

SR-RICE POLYPEPTIDE-1ANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

STEAPYRIUM CHLORIDEANTIMICROBIAL, ANTISTATIC

STEARDIMONIUM PROPYL CHORIDE SILSESQUIOXANE SILICATEANTIMICROBIAL; FILM FORMING; SURFACTANT - CLEANSING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SR-HONEY BEE DEFENSIN-1 appears in the CosIng inventory

The CosIng inventory lists SR-HONEY BEE DEFENSIN-1 as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SR-HONEY BEE DEFENSIN-1 is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SR-HONEY BEE DEFENSIN-1 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SR-HONEY BEE DEFENSIN-1 carries the following function designation(s):

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for SR-HONEY BEE DEFENSIN-1

This page reproduces the CosIng inventory entry for SR-HONEY BEE DEFENSIN-1 from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SR-HONEY BEE DEFENSIN-1 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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