Is ECKOL safe to use in EU cosmetics?

ECKOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does ECKOL serve in cosmetics?

According to the EU CosIng inventory, ECKOL carries the following function designation(s): HAIR CONDITIONING, SKIN PROTECTING, SKIN CONDITIONING - MISCELLANEOUS.

What other records share CAS 88798-74-7?

CAS 88798-74-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains ECKOL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1014812024-06-28

ECKOL

Eckol is the organic compound that conforms to the formula

ECKOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 88798-74-7

CAS 88798-74-7PubChem CID 145937

Eckol

Eckol is a phlorotannin that is oxanthrene-1,3,6,8-tetrol substituted by a 3,5-dihydroxyphenoxy moiety at position 4. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity. It has a role as an antioxidant and a metabolite. It is functionally related to a phloroglucinol. — ChEBI

IUPAC name: 4-(3,5-dihydroxyphenoxy)dibenzo-p-dioxin-1,3,6,8-tetrol

Molecular formula: C18H12O9
Molecular weight: 372.3 g/mol
Exact mass: 372.04813196 Da
XLogP3: 2.5
Topological polar surface area: 149.0 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 9
Covalent units: 1
Defined stereocentres: 0

Also known as

1-(3,5-Dihydroxyphenoxy)-2,4,7,9-tetrahydroxydibenzo-1,4-dioxin4-(3,5-dihydroxyphenoxy)oxanthrene-1,3,6,8-tetrol4A5E8354UBCHEBI:65819RefChem:1362564-(3,5-dihydroxyphenoxy)-dibenzo(b,e)(1,4)dioxin-1,3,6,8-tetrol4-(3,5-Dihydroxyphenoxy)dibenzo[b,e][1,4]dioxine-1,3,6,8-tetraolDibenzo[b,e][1,4]dioxin-1,3,6,8-tetrol, 4-(3,5-dihydroxyphenoxy)-

7 more reported names

DIBENZO(B,E)(1,4)DIOXIN-1,3,6,8-TETROL, 4-(3,5-DIHYDROXYPHENOXY)-UNII-4A5E8354UBDA-63108HY-114203CS-00795194-(3,5-DIHYDROXYPHENOXY)DIBENZO(B,E)(1,4)DIOXIN-1,3,6,8-TETROLDibenzo(b,e)(1,4)-dioxin-1,3,6,8-tetrol, 4-(3,5-dihydroxyphenoxy)-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:65819
ChEMBL:CHEMBL471187
EPA DTXSID:DTXSID40237333
PubMed:24700636
PubMed:22754373
PubMed:22687478
PubMed:22587607
PubMed:22543027
PubMed:22530035
PubMed:22511271
PubMed:22504532
PubMed:22465981
PubMed:22363250
PubMed:22319609
PubMed:22259673

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 101481
Published in the Official Journal: Yes
Recorded by the Commission: 2024-06-28

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for ECKOL

INCI name

ECKOL

Description

Eckol is the organic compound that conforms to the formula

Record provenance

Inventory reference: cosing-live-101481
Imported identity: ECKOL
Source update: 2024-06-28

European Commission CosIng source notes

Annex records for ECKOL

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Key data

CAS

88798-74-7

—

Restriction

—

Function

HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.
SKIN CONDITIONING - MISCELLANEOUS: Enhancing the appearance of dry and/or damaged skin by reducing flaking and restoring suppleness.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9714 · ECKOL

Ingredients with overlapping formulation functions

ECHINACEA PURPUREA FLOWER OILFRAGRANCE; PERFUMING; SKIN CONDITIONING - MISCELLANEOUS

ECHINACEA PURPUREA ROOT WATERSKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - MISCELLANEOUS

ECHINOCHLOA ESCULENTA BRAN EXTRACTSKIN CONDITIONING - MISCELLANEOUS

ECKLONIA CAVA VESICLESSKIN CONDITIONING - MISCELLANEOUS

EDENIA GOMEZPOMPAE FERMENT LYSATE EXTRACTANTIOXIDANT; SKIN CONDITIONING - EMOLLIENT; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - MISC…

EGG WHITE VESICLESSKIN CONDITIONING - MISCELLANEOUS

ELAEAGNUS ANGUSTIFOLIA FRUIT EXTRACTANTIOXIDANT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - MISCELLANEOUS

ELAEIS GUINEENSIS OIL EXTRACTANTIOXIDANT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - MISCELLANEOUS

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ECKOL appears in the CosIng inventory

The CosIng inventory lists ECKOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ECKOL is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ECKOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ECKOL carries the following function designation(s):

CAS 88798-74-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for ECKOL

This page reproduces the CosIng inventory entry for ECKOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ECKOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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