Is PHYTOFLUENE safe to use in EU cosmetics?

PHYTOFLUENE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

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InventoryRef cosing-live-1011652024-07-02

PHYTOFLUENE

Phytofluene is the organic compound that conforms generally to the formula

PHYTOFLUENE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 27664-65-9

CAS 27664-65-9PubChem CID 6857557

Phytofluene, (15Z)-

15-cis-phytofluene is a phytofluene. — ChEBI

IUPAC name: (6E,10E,12E,14E,16Z,18E,22E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,10,12,14,16,18,22,26,30-decaene

Molecular formula: C40H62
Molecular weight: 542.9 g/mol
Exact mass: 542.485151978 Da
XLogP3: 15.4
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 0
Covalent units: 1
Defined stereocentres: 0

Also known as

Ibr-clccis-Phytofluene3V8034L59CLycopene, 7,7',8,8',11,12-hexahydro-, 15-cis-omega,omega-Carotene, 7,7',8,8',11,12-hexahydro-, 15-cis-RefChem:109557615-cis-phytofluene(15Z)-Phytofluene

9 more reported names

UNII-3V8034L59C(E/Z)-Phytofluenecis-7,7',8,8',11,12-Hexahydro-Carotene(15Z)-7,8,11,12,7',8'-Hexahydro-psi,psi-carotene(15cis)-7,7',8,8',11',12'-Hexahydro-psi,psi-carotene(15Z)-Phytofluene; 15-cis-Phytofluene; Hexahydrolycopenepsi,psi-Carotene, 7,7',8,8',11,12-hexahydro-, 15-cis-.OMEGA.,.OMEGA.-CAROTENE, 7,7',8,8',11,12-HEXAHYDRO-, 15-CIS-(12E,16Z,18E,22E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,10,12,14,16,18,22,26,30-decaene

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:35165
EPA DTXSID:DTXSID40904730
PubMed:5038263

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 540-05-6

CAS 540-05-6PubChem CID 6436722

All-Trans-Phytofluene

All-trans-phytofluene is the all-trans-isomer of phytofluene. It has a role as a plant metabolite and a human xenobiotic metabolite. — ChEBI

IUPAC name: (6E,10E,12E,14E,16E,18E,22E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,10,12,14,16,18,22,26,30-decaene

Molecular formula: C40H62
Molecular weight: 542.9 g/mol
Exact mass: 542.485151978 Da
XLogP3: 15.4
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 0
Covalent units: 1
Defined stereocentres: 0

Also known as

Phytofluene6NUO4W7YQ67,7',8,8',11,12-hexahydro-psi,psi-carotene7,8,11,12,7',8'-hexahydro-psi,psi-caroteneIBR-TCLCPHYTOFLUENE, ALL-TRANS-CHEBI:28129psi,psi-Carotene, 7,7',8,8',11,12-hexahydro-

16 more reported names

(12E,16E,18E,22E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,10,12,14,16,18,22,26,30-decaeneCHEBI:26120CHEBI:35165RefChem:91540715-cis-7,8,11,12,7',8'-hexahydro-psi,psi-carotene15-Cis-Phytofluene (SY)PHYTOFLUENE 16 (17-E/Z MIXTURE)UNII-6NUO4W7YQ62,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,10,12,14,16,18,22,26,30-decaeneOVSVTCFNLSGAMM-OUOOUFEBSA-Nall-trans phytofluenePHYTOFLUENE [MI]ALL-(E)-PHYTOFLUENEPHYTOFLUENE, ALL TRANSHY-N12957TN7847

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28129
EPA DTXSID:DTXSID40894763
PubMed:17051425

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 101165
Published in the Official Journal: Yes
Recorded by the Commission: 2024-07-02

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for PHYTOFLUENE

INCI name

PHYTOFLUENE

Description

Phytofluene is the organic compound that conforms generally to the formula

Record provenance

Inventory reference: cosing-live-101165
Imported identity: PHYTOFLUENE
Source update: 2024-07-02

European Commission CosIng source notes

Annex records for PHYTOFLUENE

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Key data

CAS

27664-65-9 (cis-)/ 540-05-6 (trans-)

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Restriction

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Function

UV FILTER: Exclusively or mainly intended to protect the skin and/or hair against certain UV radiation by absorbing, reflecting or scattering UV radiation. All authorised UV filters are substances in the positive list of Annex VI to the Cosmetics Regulation 1223/2009.
SKIN CONDITIONING - OCCLUSIVE: Retarding the evaporation of water from the skin surface. Occlusives are generally lipids which tend to remain on the skin surface and thus increase the water content of skin.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#20892 · PHYTOFLUENE

Ingredients with overlapping formulation functions

PEDIOCOCCUS FERMENT LYSATESKIN CONDITIONING - EMOLLIENT; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - MISCELLANEOUS; SK…

PENTYL 3-GLYCERYL ASCORBATEANTIOXIDANT; SKIN CONDITIONING - EMOLLIENT; HUMECTANT; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIO…

PETROSELINIC ACIDANTI-SEBORRHEIC; ANTIMICROBIAL; SKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING; SKIN CONDITIONING -…

PHYTOENEHAIR CONDITIONING; LIGHT STABILIZER; UV FILTER; SKIN CONDITIONING - OCCLUSIVE

POLYCITRONELLOL ACETATEFRAGRANCE, HAIR CONDITIONING, HAIR WAVING OR STRAIGHTENING, HUMECTANT, SKIN CONDITIONING - EMOLLIEN…

PROPYLENE GLYCOL AZELATE ESTERSANTI-SEBUM; SKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING; SKIN CONDITIONING - OCCLUSIVE

RAMULARIA COCCINEA FERMENT FILTRATE LYSATE EXTRACT FILTRATESKIN CONDITIONING - OCCLUSIVE

S-WATER BEAR OCTAPEPTIDE-1ANTIOXIDANT; SKIN PROTECTING; EYELASH CONDITIONING; SKIN CONDITIONING - OCCLUSIVE

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PHYTOFLUENE appears in the CosIng inventory

The CosIng inventory lists PHYTOFLUENE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PHYTOFLUENE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PHYTOFLUENE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PHYTOFLUENE carries the following function designation(s):

CAS 27664-65-9 (cis-)/ 540-05-6 (trans-) may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for PHYTOFLUENE

This page reproduces the CosIng inventory entry for PHYTOFLUENE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PHYTOFLUENE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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