Is SAKURANETIN safe to use in EU cosmetics?

SAKURANETIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

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InventoryRef cosing-live-1003232023-05-23

SAKURANETIN

Sakuranetin is the organic compound that conforms to the formula

SAKURANETIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 2957-21-3

CAS 2957-21-3PubChem CID 73571

Sakuranetin

Sakuranetin is a flavonoid phytoalexin that is (S)-naringenin in which the hydroxy group at position 7 is replaced by a methoxy group. It has a role as an antimycobacterial drug and a plant metabolite. It is a member of 4'-hydroxyflavanones, a (2S)-flavan-4-one, a monomethoxyflavanone, a dihydroxyflavanone and a flavonoid phytoalexin. It is functionally related to a (S)-naringenin. — ChEBI

IUPAC name: (2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one

Molecular formula: C16H14O5
Molecular weight: 286.28 g/mol
Exact mass: 286.08412354 Da
XLogP3: 2.7
Topological polar surface area: 76.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 1

Also known as

(2S)-sakuranetinNaringenin 7-methyl ether5,4'-Dihydroxy-7-methoxyflavanone(S)-(-)-4',5-dihydroxy-7-methoxyflavanone5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-chroman-4-one3O38P61299CHEBI:289274H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (S)-

16 more reported names

(2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-oneRefChem:180866220-980-5(S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-one4',5-Dihydroxy-7-methoxyflavanone7-O-Methylnaringenin4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (2S)-(2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one(2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-chroman-4-oneDihydrogenkwaninUNII-3O38P61299EINECS 220-980-5NSC 407228SAKURANETIN [MI]GTPL412Flavanone, 4',5-dihydroxy-7-methoxy-, (S)-(-)-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28927
ChEMBL:CHEMBL448297
PubMed:38403145
PubMed:22980899
PubMed:22895058
PubMed:22860454
PubMed:22512738
PubMed:22493492
PubMed:22243810
PubMed:22186340
PubMed:22150672
PubMed:22143090
PubMed:22059530
PubMed:21871644

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 520-29-6

CAS 520-29-6PubChem CID 348130

4'-5-Dihydroxy-7-methoxyflavanone, 7-O-Methylnaringenin, Naringenin 7-O-methyl ether

sakuranetin has been reported in Daphne aurantiaca, Prunus cerasus, and other organisms with data available. — LOTUS - the natural products occurrence database

IUPAC name: 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one

Molecular formula: C16H14O5
Molecular weight: 286.28 g/mol
Exact mass: 286.08412354 Da
XLogP3: 2.7
Topological polar surface area: 76.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

RefChem:505952112-126-45-hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-one(RS)-SakuranetinNSC-4072285-Hydroxy-2-(4-hydroxy-phenyl)-7-methoxy-chroman-4-one4H-1-Benzopyran-4-one,2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-3,4-dihydro-2H-1-benzopyran-4-one

13 more reported names

4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-MEGxp0_0005575-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one #ACon1_0000014H-1-Benzopyran-4-one,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (S)-HMS2271F135,4''-Dihydroxy-7-o-methoxyflavanoneAC-20247AC-34929CS-0066106Flavanone,5-dihydroxy-7-methoxy-, (S)-(-)-BRD-A32263173-001-01-25-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydro-4H-1-benzopyran-4-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL74852
EPA DTXSID:DTXSID10874774
PubMed:22441335
PubMed:22259537
PubMed:22148193
PubMed:22143090
PubMed:19439809
PubMed:17873840
PubMed:16105233
PubMed:12576658
PubMed:11576606

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 100323
Entry status: Active
Published in the Official Journal: Yes
Recorded by the Commission: 2023-05-23

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for SAKURANETIN

INCI name

SAKURANETIN

Description

Sakuranetin is the organic compound that conforms to the formula

Record provenance

Inventory reference: cosing-live-100323
Imported identity: SAKURANETIN
Source update: 2023-05-23

European Commission CosIng source notes

Annex records for SAKURANETIN

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Key data

CAS

2957-21-3/520-29-6

220-980-5/-

Restriction

—

Function

SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#25070 · SAKURANETIN

Ingredients with overlapping formulation functions

SACCHAROMYCES/TRITICUM AESTIVUM SEED FERMENT EXTRACTANTIOXIDANT, HUMECTANT, SKIN PROTECTING

SACCHARUM OFFICINARUM LEAF/STEM POWDERANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, NAIL CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN P…

SACCHARUM OFFICINARUM WAXBINDING, EMULSION STABILISING, SKIN PROTECTING

SAHEL SCENEDESMUS EXTRACTSKIN PROTECTING

SALCOLINSKIN CONDITIONING, SKIN PROTECTING

SALICYLOYL OCTAPEPTIDE-9ANTI-SEBUM, ANTIMICROBIAL, ANTIOXIDANT, SKIN PROTECTING

SALICYLOYL PENTAPEPTIDE-33ANTIOXIDANT, SKIN PROTECTING

SALICYLOYL SH-NONAPEPTIDE-12ANTIMICROBIAL; ANTIOXIDANT; ANTI-SEBUM; SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SAKURANETIN appears in the CosIng inventory

The CosIng inventory lists SAKURANETIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SAKURANETIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SAKURANETIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SAKURANETIN carries the following function designation(s):

SKIN PROTECTING

CAS 2957-21-3/520-29-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SAKURANETIN

This page reproduces the CosIng inventory entry for SAKURANETIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SAKURANETIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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