Is DILTIAZEM HCL safe to use in EU cosmetics?

DILTIAZEM HCL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 33286-22-5?

CAS 33286-22-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains DILTIAZEM HCL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef cosing-live-1003002023-05-23

DILTIAZEM HCL

Diltiazem HCl is the organic compound that conforms to the formula

DILTIAZEM HCL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 33286-22-5

CAS 33286-22-5PubChem CID 62920

Diltiazem Hydrochloride

Diltiazem hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension. It has a role as a vasodilator agent, an antihypertensive agent and a calcium channel blocker. It contains a diltiazem(1+). It is an enantiomer of an ent-diltiazem hydrochloride. — ChEBI

IUPAC name: [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride

Molecular formula: C22H27ClN2O4S
Molecular weight: 451.0 g/mol
Exact mass: 450.1380062 Da
Topological polar surface area: 84.4 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 6
Covalent units: 2
Defined stereocentres: 2

Also known as

Diltiazem HClAdizemDilzemDilzeneMasdilAltiazemDeltazenDiladel

16 more reported names

DilpralDilreneTildiemCardizem LABritiazimZildenCardizem CDDilacorDiltzacCardizem SRCartia XTTaztia XTViazem XLCartiaRG 83606TAZTIA

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:645509
ChEMBL:CHEMBL1697
EPA DTXSID:DTXSID8040147

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official European Commission record

CosIng substance ID: 100300
Entry status: Active
Published in the Official Journal: Yes
Recorded by the Commission: 2023-05-23

Open this entry in the official CosIng database

Fields as published by the European Commission. The link opens the entry itself, not a search for it.

Inventory details for DILTIAZEM HCL

INCI name

DILTIAZEM HCL

Description

Diltiazem HCl is the organic compound that conforms to the formula

Record provenance

Inventory reference: cosing-live-100300
Imported identity: DILTIAZEM HCL
Source update: 2023-05-23

European Commission CosIng source notes

Annex records for DILTIAZEM HCL

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching DILTIAZEM HCL or related substances.

Key data

CAS

33286-22-5

—

Restriction

—

Function

ASTRINGENT: Contracting and/or tightening the skin.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#8828 · DILTIAZEM HCl

Ingredients with overlapping formulation functions

CYMBIDIUM LANCIFOLIUM EXTRACTANTIOXIDANT, ASTRINGENT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

CYMBOPOGON SCHOENANTHUS LEAF POWDERASTRINGENT, SKIN CONDITIONING

DAEMONOROPS DRACO EXTRACTASTRINGENT

DICTAMNUS ALBUS ROOT EXTRACTASTRINGENT, HAIR CONDITIONING, SKIN CONDITIONING

DIMETHYLAMIDOMETHYL TETRAHYDROCARBAZOLECARBOXYLATEASTRINGENT; SKIN CONDITIONING - EMOLLIENT; SKIN CONDITIONING - MISCELLANEOUS

DIOSCOREA BATATAS EXTRACTANTIOXIDANT, ASTRINGENT, HAIR CONDITIONING, SKIN CONDITIONING - EMOLLIENT

DIOSPYROS KAKI FRUIT JUICEANTIOXIDANT, ASTRINGENT, DEODORANT, ORAL CARE

DIPHYLLEIA GRAYI CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, HAIR CONDITIONING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DILTIAZEM HCL appears in the CosIng inventory

The CosIng inventory lists DILTIAZEM HCL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DILTIAZEM HCL is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DILTIAZEM HCL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, DILTIAZEM HCL carries the following function designation(s):

CAS 33286-22-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for DILTIAZEM HCL

This page reproduces the CosIng inventory entry for DILTIAZEM HCL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research DILTIAZEM HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect DILTIAZEM HCL and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to DILTIAZEM HCL, its identifiers or nearby name variants.