InventoryRef 9716126/04/2019
PERFLUOROPROPYLENE
1,1,2,3,3,3-Hexafluoroprop-1-ene; 1,1,2,3,3,3-Hexafluoropropene; Hexafluoroprop-1-ene; Hexafluoropropene; HEXAFLUOROPROPENE (HFP); hexafluoropropylene; Hexafluorpropen
PERFLUOROPROPYLENE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
CAS 116-15-4PubChem CID 8302
Hexafluoropropylene
Hexafluoropropylene is an odorless, colorless gas. It is noncombustible. It can asphyxiate by the displacement of air. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. — CAMEO Chemicals
- IUPAC name
- 1,1,2,3,3,3-hexafluoroprop-1-ene
- Molecular formula
- C3F6
- Molecular weight
- 150.02 g/mol
- Exact mass
- 149.99041897 Da
- XLogP3
- 1.9
- Topological polar surface area
- 0.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 6
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
HexafluoropropenePerfluoropropenePerfluoropropylenePropene, hexafluoro-Perfluoro-1-propenePropylene, hexafluoro-Hexfluoropropylene1,1,2,3,3,3-HEXAFLUORO-1-PROPENE
16 more reported names
1-Propene, 1,1,2,3,3,3-hexafluoro-propylene hexafluorideTRW23XOS20RefChem:146013204-127-4C3F6CF3CF=CF2R1216hexafluoro-1-propeneHexafluoroprop-1-eneEsafluoropropeneHSDB 5582EINECS 204-127-4UN1858UNII-TRW23XOS20hexafluoro-propene
External database identifiers
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match8302
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: -29.6 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: -29.6 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Color/Form: Colorless gas Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.583 AT -40 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.583 @ -40°C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: -156.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -156.5 °C Source: PAC Chemical Database, U.S. Department of Energy
- Odor: Odorless gas Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Hexafluoropropylene is an odorless, colorless gas. It is noncombustible. It can asphyxiate by the displacement of air. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. Source: CAMEO Chemicals
- Physical Description: Liquid; Gas Vapor Source: EPA Chemical Data Reporting (CDR)
- Physical Description: An odorless, colorless, noncombustible gas that can act as a simple asphyxiant; [CAMEO] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 4900.0 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 4.9X10+3 mm Hg at 25 °C /from experimentally derived coefficients/ Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 750 [mm Hg] @-30.6 °C Source: PAC Chemical Database, U.S. Department of Energy
- First Aid: Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:; Refer to the "General First Aid" section. Specific First Aid: In case of contact with liquefied gas, only medical personnel should attempt thawing frosted parts. (ERG, 2024) Source: CAMEO Chemicals
- ERG2024, Guide 126 (Refrigerant gas R-1216): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- ERG2024, Guide 126 (Hexafluoropropylene; Hexafluoropropylene, compressed): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P261, P271, P304+P340, P317, P319, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H280 (89.5%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351 (48.6%): Suspected of causing cancer [Warning Carcinogenicity]; H371 (34.6%): May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373 (38.1%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H412 (26.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P260, P261, P264, P270, P271, P273, P280, P304+P340, P308+P316, P317, P318, P319, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 457 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Precautionary Statement Codes: P260, P261, P264, P270, P271, P304+P340, P308+P316, P317, P319, P321, P405, P410+P403, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Environmental Bioconcentration: An estimated BCF value of 24 was calculated for hexafluoropropene(SRC), using an estimated log Kow of 2.12(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to have moderate mobility in soil(SRC). Volatilization of hexafluoropropene is expected from moist soil surfaces(SRC) given an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Hexafluoropropene is expected to rapidly volatilize from dry soil surfaces based on a vapor pressure of 4.9X10+3 mm Hg(SRC), determined from a fragment constant method(4). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(5). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to adsorb to suspended solids and sediment in water(SRC). Hexafluoropropene is expected to volatilize rapidly from water surfaces(3,SRC) based on an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated half-lives for a model river and model lake are 4 and 116 hours, respectively(3,SRC). According to a classification scheme(5), an estimated BCF value of 24(3,SRC), from an estimated log Kow of 2.12(6,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(7). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexafluoropropene, which has a vapor pressure of 4.9X10+3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hexafluoropropene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone molecules(SRC); the half-lives for these reactions in air are estimated to be about 21(3,SRC) and 95(4,SRC) days, respectively. Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Monomers Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Intermediate; Monomers Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: About 90% is used as a monomer in closed systems to produce fluoropolymers, fluoroelastomers, and fluorolubricants; About 10% is used to produce replacement chlorofluorocarbons; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: MONOMER FOR FLUORINATED ETHYLENE-PROPYLENE COPOLYMERS Source: Hazardous Substances Data Bank (HSDB)
- Uses: COMONOMER FOR VINYLIDENE FLUORIDE ELASTOMERS Source: Hazardous Substances Data Bank (HSDB)
- Uses: CHEM INT FOR PERFLUOROALKYL POLYETHER FLUIDS Source: Hazardous Substances Data Bank (HSDB)
- Uses: Production of copolymers and hexafluoropropylene oxide. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for PERFLUOROPROPYLENE
INCI name
PERFLUOROPROPYLENE
Description
1,1,2,3,3,3-Hexafluoroprop-1-ene; 1,1,2,3,3,3-Hexafluoropropene; Hexafluoroprop-1-ene; Hexafluoropropene; HEXAFLUOROPROPENE (HFP); hexafluoropropylene; Hexafluorpropen
Record provenance
- Inventory reference
- 97161
- Imported identity
- PERFLUOROPROPYLENE
- Source update
- 26/04/2019
Annex records for PERFLUOROPROPYLENE
Key data
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How PERFLUOROPROPYLENE appears in the CosIng inventory
The CosIng inventory lists PERFLUOROPROPYLENE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
PERFLUOROPROPYLENE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
PERFLUOROPROPYLENE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, PERFLUOROPROPYLENE carries the following function designation(s):
CAS 116-15-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for PERFLUOROPROPYLENE
This page reproduces the CosIng inventory entry for PERFLUOROPROPYLENE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research PERFLUOROPROPYLENE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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