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InventoryRef 9712315/04/2019

O-PHOSPHOSERINE

2-amino-3-(phosphonooxy)propanoic acid; O-Phospho-L-Serine; O-phosphonoserine

O-PHOSPHOSERINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 407-41-0
CAS 407-41-0PubChem CID 68841

Phospho-L-serine

O-phospho-L-serine is the L-enantiomer of O-phosphoserine. It has a role as an EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, an EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor, an EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor and a human metabolite. It is a conjugate acid of an O-phosphonato-L-serine(2-). It is an enantiomer of an O-phospho-D-serine. — ChEBI

IUPAC name
(2S)-2-amino-3-phosphonooxypropanoic acid
Molecular formula
C3H8NO6P
Molecular weight
185.07 g/mol
Exact mass
185.00892397 Da
XLogP3
-5.1
Topological polar surface area
130.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
1

Also known as

O-phospho-L-serineDexfosfoserineL-O-PhosphoserineFosforinaL-Phosphoserineserine phosphateseriphosL-O-Serine phosphate
16 more reported names
O-Phosphoryl-L-serine(+)-L-Serine dihydrogen phosphate (ester)O-phosphoserine, l-DexfosfoserinaGNF-Pf-1028NSC-760136VI4F0K069V3-phospho-L-serineCHEBI:15811NSC-90791dexfosfoserinumRefChem:1095127(2S)-2-azaniumyl-3-phosphonooxypropanoate206-986-0EnergoserinaSerophen
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 73913-63-0
CAS 73913-63-0PubChem CID 439747

O-phospho-D-serine

O-phospho-D-serine is the D-enantiomer of O-phosphoserine. It is a conjugate acid of an O-phosphonatooxy-D-serine(2-). It is an enantiomer of an O-phospho-L-serine. — ChEBI

IUPAC name
(2R)-2-amino-3-phosphonooxypropanoic acid
Molecular formula
C3H8NO6P
Molecular weight
185.07 g/mol
Exact mass
185.00892397 Da
XLogP3
-5.1
Topological polar surface area
130.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
1

Also known as

O-phosphono-D-serine(2R)-2-amino-3-(phosphonooxy)propanoic acidCHEBI:37713RefChem:1093704D-Serine, O-phosphono-D-O-PhosphoserinePhosphoserine, D-o-Phosphoserine, D-
12 more reported names
D-2-Amino-3-hydroxypropanoic acid 3-phosphateUNII-415ENH7NZL415ENH7NZL(R)-2-Amino-3-(phosphonooxy)propanoic acidPDSP1_001488C3H8NO6PH-D-Ser(PO3H2)-OHD-Ser(H2PO3)-OHH-D-Ser(PO)-OHLopac-P-0878PDSP2_001472(2R)-2-amino-3-phosphonooxy-propanoic acid
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for O-PHOSPHOSERINE

INCI name

O-PHOSPHOSERINE

Description

2-amino-3-(phosphonooxy)propanoic acid; O-Phospho-L-Serine; O-phosphonoserine

Record provenance

Inventory reference
97123
Imported identity
O-PHOSPHOSERINE
Source update
15/04/2019
European Commission CosIng source notes
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Key data

CAS
407-41-0, 73913-63-0
EC
206-986-0
Restriction
—
Function
HAIR CONDITIONING
Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#18321 · O-PHOSPHOSERINE

Ingredients with overlapping formulation functions

NYLON-611/DIMETHICONE COPOLYMERHAIR CONDITIONING, SKIN CONDITIONING, VISCOSITY CONTROLLING
NYMPHAEA GIGANTEA FLOWER EXTRACTANTIOXIDANT, FRAGRANCE, HAIR CONDITIONING, PERFUMING, SKIN PROTECTING
NYMPHAEA TETRAGONA CALLUS CULTURE EXTRACTANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING
NYMPHAEA TETRAGONA PHYTOPLACENTA EXTRACTANTIMICROBIAL, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING
OAT AMINO ACIDSHAIR CONDITIONING, SKIN CONDITIONING
OATAMIDOPROPYL DIMETHYLAMINEANTISTATIC, HAIR CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING
OCIMUM BASILICUM EXTRACTANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING
OCIMUM TENUIFLORUM CALLUS CULTURE LYSATEANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN CONDITIONING - HUMECTANT, SLIP …

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How O-PHOSPHOSERINE appears in the CosIng inventory

The CosIng inventory lists O-PHOSPHOSERINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

O-PHOSPHOSERINE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

O-PHOSPHOSERINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, O-PHOSPHOSERINE carries the following function designation(s):

CAS 407-41-0, 73913-63-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
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Source note for O-PHOSPHOSERINE

This page reproduces the CosIng inventory entry for O-PHOSPHOSERINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research O-PHOSPHOSERINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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