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CAS 625-72-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9679329/03/2019

3-HYDROXYBUTYRIC ACID

3-Hydroxybutyric Acid is the organic compound that conforms to the formula:

3-HYDROXYBUTYRIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 625-72-9

CAS 625-72-9PubChem CID 92135

3-Hydroxybutanoic acid, (R)-

(R)-3-hydroxybutyric acid is the R-enantiomer of 3-hydroxybutyric acid. Involved in the synthesis and degradation of ketone bodies, it can be used as an energy source by the brain during hypoglycaemia, and for the synthesis of biodegradable plastics. It is a sex pheremone in the European spider Linyphia triangularis. It has a role as a pheromone, a fungal metabolite and a human metabolite. It is a 3-hydroxybutyric acid and a ketone body. It is a conjugate acid of a (R)-3-hydroxybutyrate. It is an enantiomer of a (S)-3-hydroxybutyric acid. — ChEBI

IUPAC name: (3R)-3-hydroxybutanoic acid

Molecular formula: C4H8O3
Molecular weight: 104.10 g/mol
Exact mass: 104.047344113 Da
XLogP3: -0.5
Topological polar surface area: 57.5 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 1

Also known as

(R)-3-Hydroxybutyric acidButanoic acid, 3-hydroxy-, (3R)-3-D-hydroxybutyric acid(-)-beta-Hydroxybutyrate, D-b-Hydroxybutyrate148ULJ1DF4EINECS 210-909-6CHEBI:17066

16 more reported names

3-HYDROXYBUTYRIC ACID, (R)3-HYDROXYBUTYRIC ACID, (R)-D-(-)-.BETA.-HYDROXYBUTYRIC ACID.BETA.-HYDROXYBUTYRIC ACID L-FORM [MI]3-hydroxy-butyrateRefChem:502534D-(-)-beta-HYDROXYBUTYRIC ACIDBETA-HYDROXYBUTYRIC ACID L-FORM210-909-6(R)-3-Hydroxybutanoic acid(R)-3-HydroxybutanoateD-3-hydroxybutyric acid(R)-(-)-3-Hydroxybutyric acidD-(-)-3-hydroxybutyrate(R)-(-)-beta-Hydroxybutyric aciddelta-3-hydroxybutyrate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17066
ChEMBL:CHEMBL1162484
EPA DTXSID:DTXSID3041829
PubMed:19605355
PubMed:15929991
PubMed:14695807
PubMed:11846645
PubMed:5415

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 3-HYDROXYBUTYRIC ACID

INCI name

3-HYDROXYBUTYRIC ACID

Description

3-Hydroxybutyric Acid is the organic compound that conforms to the formula:

Record provenance

Inventory reference: 96793
Imported identity: 3-HYDROXYBUTYRIC ACID
Source update: 29/03/2019

European Commission CosIng source notes

Annex records for 3-HYDROXYBUTYRIC ACID

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Key data

CAS

625-72-9

210-909-6 (I)

Restriction

—

Function

ANTI-SEBUM: Helping control sebum production.
HUMECTANT: Retaining and/or preserving the moisture in a product during use.
PLASTICISER: Softening and making supple synthetic polymers that otherwise could not be easily deformed, spread or worked out.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#286 · 3-HYDROXYBUTYRIC ACID

Ingredients with overlapping formulation functions

ACETYL TRIBUTYL CITRATEFRAGRANCE, PERFUMING, PLASTICISER

ACETYL TRIETHYL CITRATEFILM FORMING, FRAGRANCE, PERFUMING, PLASTICISER

ACETYL TRIETHYLHEXYL CITRATEFILM FORMING, PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

ACETYL TRIHEXYL CITRATEANTIOXIDANT, CHELATING, PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

ACETYLATED HYDROGENATED CASTOR GLYCERIDEPLASTICISER

ACRYLATES/VA/VINYL NEODECANOATE COPOLYMERPLASTICISER

ACRYLOYL MORPHOLINEPLASTICISER

ACRYLOYLOXYETHYL PHTHALATEFILM FORMING, PLASTICISER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 3-HYDROXYBUTYRIC ACID appears in the CosIng inventory

The CosIng inventory lists 3-HYDROXYBUTYRIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

3-HYDROXYBUTYRIC ACID is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

3-HYDROXYBUTYRIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, 3-HYDROXYBUTYRIC ACID carries the following function designation(s):

CAS 625-72-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for 3-HYDROXYBUTYRIC ACID

This page reproduces the CosIng inventory entry for 3-HYDROXYBUTYRIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

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