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CAS 2226-96-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9674615/04/2019

HYDROXY TETRAMETHYLPIPERIDINE OXIDE

HYDROXY TETRAMETHYLPIPERIDINE OXIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 2226-96-2

CAS 2226-96-2PubChem CID 137994

Tempol

Tempol has been used in trials studying the treatment of Anal Cancer. — DrugBank

Molecular formula: C9H18NO2
Molecular weight: 172.24 g/mol
Exact mass: 172.133753817 Da
XLogP3: 0.9
Topological polar surface area: 24.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Tanol4-OxypiperidolTMPNHyTEMPONitroxyl 21-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxylMBM-02

16 more reported names

U78ZX2F65XSPJ-7012,2,6,6-Tetramethyl-4-hydroxypiperidinooxy2,2,6,6-Tetramethyl-4-piperidinol 1-oxyl2,2,6,6-Tetramethyl-4-piperidinol-N-oxyl4-Hydroxy-2,2,6,6-tetramethylpiperidinooxy4-Hydroxy-2,2,6,6-tetramethylpiperidinooxylZJ-7014-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxylNSC-1427842,2,6,6-Tetramethyl-4-hydroxypiperidinooxy radical4-Hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl(4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanylPIPERIDINOOXY, 4-HYDROXY-2,2,6,6-TETRAMETHYL-2,2,6,6-Tetramethyl-4-piperidinol N-oxyl2,2,6,6-Tetramethyl-4-piperidinol-1-oxy

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:180664
ChEMBL:CHEMBL607023
EPA DTXSID:DTXSID4041280
PubMed:38454815
PubMed:36513130
PubMed:32726580
PubMed:31054354
PubMed:30346588
PubMed:29609002
PubMed:28633109
PubMed:28039404
PubMed:27128347
PubMed:26177467
PubMed:25817889
PubMed:25787151

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HYDROXY TETRAMETHYLPIPERIDINE OXIDE

INCI name

HYDROXY TETRAMETHYLPIPERIDINE OXIDE

Description

1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine; 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-; 1-λ1-Oxidanyl-2,2,6,6-tetramethylpiperidin-4-ol
2,2,6,6-tetramethylpiperidine-1,4-diol; 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy; 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical; 4-Hydroxy-2,2,6,6-tetramethylpiperidinoxy; 4-Hydroxy-2,2,6,6-tetramethylpiperidinoxyl; 4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINOXYL-; 4-Hydroxy-TEMPO; HTMPO; Hydroxy Tempo

Record provenance

Inventory reference: 96746
Imported identity: HYDROXY TETRAMETHYLPIPERIDINE OXIDE
Source update: 15/04/2019

European Commission CosIng source notes

Annex records for HYDROXY TETRAMETHYLPIPERIDINE OXIDE

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Key data

CAS

2226-96-2

218-760-9

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#13189 · HYDROXY TETRAMETHYLPIPERIDINE OXIDE

Ingredients with overlapping formulation functions

HYDROLYZED WHEAT BRANANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING, UV ABSOR…

HYDROLYZED WHEAT GERM EXTRACTANTIOXIDANT, SKIN CONDITIONING

HYDROLYZED YELLOW CROAKER SWIM BLADDER CELL LYSATEANTIOXIDANT; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - MISCELLANEOUS

HYDROQUINONE SAFFLOWERATESANTIOXIDANT; SKIN CONDITIONING - MISCELLANEOUS

HYDROXYACETOPHENONEANTIOXIDANT

HYDROXYBUTYROYL PHYTOSPHINGOSINEANTIOXIDANT; SKIN CONDITIONING - MISCELLANEOUS

HYDROXYDAIDZEINANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

HYDROXYDECYL UBIQUINONEANTIOXIDANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HYDROXY TETRAMETHYLPIPERIDINE OXIDE appears in the CosIng inventory

The CosIng inventory lists HYDROXY TETRAMETHYLPIPERIDINE OXIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HYDROXY TETRAMETHYLPIPERIDINE OXIDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HYDROXY TETRAMETHYLPIPERIDINE OXIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HYDROXY TETRAMETHYLPIPERIDINE OXIDE carries the following function designation(s):

ANTIOXIDANT

CAS 2226-96-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for HYDROXY TETRAMETHYLPIPERIDINE OXIDE

This page reproduces the CosIng inventory entry for HYDROXY TETRAMETHYLPIPERIDINE OXIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HYDROXY TETRAMETHYLPIPERIDINE OXIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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