What other records share CAS 87616-84-0?

CAS 87616-84-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 9608826/04/2018

HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE

Human Growth Hormone-releasing peptide 6

HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 87616-84-0

CAS 87616-84-0PubChem CID 9919153

Growth hormone releasing hexapeptide

IUPAC name: (2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide

Molecular formula: C46H56N12O6
Molecular weight: 873.0 g/mol
Exact mass: 872.44457755 Da
XLogP3: 1.9
Topological polar surface area: 301.0 Å²
Hydrogen-bond donors: 11
Hydrogen-bond acceptors: 9
Covalent units: 1
Defined stereocentres: 6

Also known as

Hexapeptide-2Melanostatine 2His(1)-lys(6)-ghrpGH-Releasing hexapeptide 6His-trp-ala-trp-phe-lysnh2His-D-Trp-Ala-Trp-D-Phe-Lys-NH2Ghrp, his(1)-lys(6)-L-Lysinamide, L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-

16 more reported names

SK&F-1106794H7N4I6X6A(D-Trp(2)-D-phe(5))ghrpU-75799ESkf 110679Histidyl-tryptophyl-alanyl-tryptophyl-phenylalanyl-lysinamideGH-releasing peptide-6RefChem:144477His-DTrp-Ala-Trp-DPhe-Lys-NH2L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-LysinamideL-Histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide Acetate SaltGH-Releasing peptideUNII-4H7N4I6X6Ah-his-d-trp-ala-trp-d-phe-lys-nh2SKF-110679SK&F 110679

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL105462
EPA DTXSID:DTXSID30904007
PubMed:16283795
PubMed:9186309
PubMed:9053785
PubMed:8772550
PubMed:8772549
PubMed:8503009
PubMed:8473389
PubMed:8421084
PubMed:8228729
PubMed:8194104
PubMed:8106194
PubMed:8051337

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

What the official INCI name states

The official label identifies a peptide- or protein-related cosmetic material.

Identity type from wording: peptide_or_protein

This structure is derived only from the official label wording. It does not establish composition, concentration, chemical equivalence, safety or regulatory permission.

Inventory details for HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE

INCI name

HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE

Description

Human Growth Hormone-releasing peptide 6

Record provenance

Inventory reference: 96088
Imported identity: HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE
Source update: 26/04/2018

European Commission CosIng source notes

Annex records for HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE

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Key data

CAS

87616-84-0

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#12096 · HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE

Ingredients with overlapping formulation functions

HIRUDINEA EXTRACTSKIN CONDITIONING

HISTIDINEANTISTATIC, HUMECTANT, SKIN CONDITIONING

HISTIDINE DNASKIN CONDITIONING

HISTIDINE HCLHAIR CONDITIONING, SKIN CONDITIONING

HIZIKIA FUSIFORME EXTRACTSKIN CONDITIONING

HOKKAIDO AKAN CLAYSKIN CONDITIONING

HOLARRHENA ANTIDYSENTERICA SEED EXTRACTSKIN CONDITIONING

HOMARINE HCLSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE appears in the CosIng inventory

The CosIng inventory lists HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE carries the following function designation(s):

SKIN CONDITIONING

CAS 87616-84-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE

This page reproduces the CosIng inventory entry for HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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