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InventoryRef 9556814/02/2018

SILYBUM MARIANUM CALLUS EXTRACT

Silybum Marianum Callus Extract is the extract of the callus of Silybum marianum grown in culture, Asteraceae.

SILYBUM MARIANUM CALLUS EXTRACT is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 84604-20-6
CAS 84604-20-6PubChem CID 5213

Silymarin

3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one is a flavonolignan. — ChEBI

IUPAC name
3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
Molecular formula
C25H22O10
Molecular weight
482.4 g/mol
Exact mass
482.12129689 Da
XLogP3
2.4
Topological polar surface area
155.0 Ų
Hydrogen-bond donors
5
Hydrogen-bond acceptors
10
Covalent units
1
Defined stereocentres
0

Also known as

Silimarin3,5,7-trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl)-2,3-dihydrochromen-4-oneRefChem:931755613-830-9SilybinFlavobin Spofa(2S)-3,5,7-trihydroxy-2-[(2S,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one(2R,3R)-3,5,7-trihydroxy-2-[(2R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
16 more reported names
Silymarin (>80%)Silibin3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxy-phenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chroman-4-one3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one4H-1-Benzopyran-4-one,2-[2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-SR-01000000093Silybin;Silibinin A;Silymarin ISilmyarinSilibinin BSilibinin, INN3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-oneSilybin (7CI)Silybum substance E6Silybin(Mixture A&B)Silibinin (mixture of Silybin A and Silybin B)Silibinin (NSC 651520)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

What the official INCI name states

The official label identifies a biological source material and its stated preparation or plant part.

Identity type from wording
biological_material
Preparation or form
CALLUS EXTRACT, EXTRACT
Stated biological parts
CALLUS
Scientific-name candidates to verify against the supplier specification
Silybum marianum

This structure is derived only from the official label wording. It does not establish composition, concentration, chemical equivalence, safety or regulatory permission.

Verified source-organism taxonomy

Exact scientific names from the INCI wording matched the immutable Catalogue of Life release shown here.

2026-07-17 XR

Silybum marianum

accepted

(L.) Gaertn.

Rank
species
Kingdom
Plantae
Family
Asteraceae
Genus
Silybum
milk-thistleEchte Mariendistel (DE); Milk ThistleMary's ThistleGewöhnliche MariendistelMarian thistleSt. Mary's Thistle (EN); Caro mariano (ES)DisseldSt. Mary's thistle
Open Catalogue of Life record

Catalogue of Life 2026-07-17 XR · DOI 10.48580/dgykv · CC BY 4.0.

Inventory details for SILYBUM MARIANUM CALLUS EXTRACT

INCI name

SILYBUM MARIANUM CALLUS EXTRACT

Description

Silybum Marianum Callus Extract is the extract of the callus of Silybum marianum grown in culture, Asteraceae.

Record provenance

Inventory reference
95568
Imported identity
SILYBUM MARIANUM CALLUS EXTRACT
Source update
14/02/2018
European Commission CosIng source notes
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Key data

CAS
84604-20-6
EC
283-298-7
Restriction
—
Function
SKIN CONDITIONING
Maintaining the skin in good condition.
SKIN CONDITIONING - EMOLLIENT
Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.
SKIN PROTECTING
Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#26161 · SILYBUM MARIANUM CALLUS EXTRACT

Other ingredients from the same source

Silybum marianum

milk-thistleMary's ThistleMarian thistle

7 other ingredients in this inventory name the same organism. Sharing a source is not sharing an identity: a leaf extract, a seed oil and a ferment are different materials with different specifications.

Records sharing a CAS or EC identity

SILYBUM MARIANUM EXTRACTSILYBUM MARIANUM FRUIT EXTRACTSILYBUM MARIANUM POWDERSILYBUM MARIANUM SEED EXTRACTSILYBUM MARIANUM SEED OIL

Ingredients with overlapping formulation functions

SILKWORM OLIGOPEPTIDE-4EMULSION STABILISING; FILM FORMING; HUMECTANT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT; SKIN…
SILLIMANITEABRASIVE, SKIN PROTECTING
SILVER SALICYLATESKIN PROTECTING
SILYBIN MALTOSIDESKIN CONDITIONING, SKIN PROTECTING
SILYBUM MARIANUM FLOWER EXTRACTSKIN PROTECTING; SKIN CONDITIONING - MISCELLANEOUS
SIMARUBA AMARA EXTRACTSKIN PROTECTING
SIMMONDSIA CHINENSIS MEAL EXTRACTHUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING
SINAPIS ARVENSIS FLOWER EXTRACTSKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How SILYBUM MARIANUM CALLUS EXTRACT appears in the CosIng inventory

The CosIng inventory lists SILYBUM MARIANUM CALLUS EXTRACT as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SILYBUM MARIANUM CALLUS EXTRACT is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SILYBUM MARIANUM CALLUS EXTRACT is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SILYBUM MARIANUM CALLUS EXTRACT carries the following function designation(s):

CAS 84604-20-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for SILYBUM MARIANUM CALLUS EXTRACT

This page reproduces the CosIng inventory entry for SILYBUM MARIANUM CALLUS EXTRACT from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SILYBUM MARIANUM CALLUS EXTRACT and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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