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InventoryRef 9530218/04/2018

TRIMETHYLHEXAMETHYLENE DIISOCYANATE

1,6-Diisocyanatotrimethylhexane,Hexane, 1,6-diisocyanatotrimethyl,TMDI,1,2,2-Trimethylhexamethylene Diisocyanate,2,2,4-Trimethylhexamethylene Diisocyanate,2,4,4-Trimethylhexamethylene Diisocyanate

TRIMETHYLHEXAMETHYLENE DIISOCYANATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 15646-96-5

CAS 15646-96-5PubChem CID 61807

Hexane, 1,6-diisocyanato-2,4,4-trimethyl-

IUPAC name: 1,6-diisocyanato-2,4,4-trimethylhexane

Molecular formula: C11H18N2O2
Molecular weight: 210.27 g/mol
Exact mass: 210.136827821 Da
XLogP3: 4.5
Topological polar surface area: 58.9 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

2,4,4-Trimethylhexamethylene diisocyanate2,4,4-TRIMETHYL-1,6-DIISOCYANATOHEXANEEINECS 239-714-4RefChem:1461142,4,4-Trimethylhexa-1,6-diyl diisocyanate2,4,4-trimethylhexamethylenediisocyanate2,4,4-trimethylhexamethylenediisocyanate [Diisocyanates]trimethyl-1,6-hexamethylene diisocyanate

1 more reported name

DB-276675

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID70864611

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 28679-16-5

CAS 28679-16-5PubChem CID 3033881

Trimethylhexa-1,6-diyl diisocyanate

Trimethylhexamethylene diisocyanate appears as a colorless liquid. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals. — CAMEO Chemicals

IUPAC name: 1,6-diisocyanato-5,6-dimethylheptane

Molecular formula: C11H18N2O2
Molecular weight: 210.27 g/mol
Exact mass: 210.136827821 Da
XLogP3: 4.2
Topological polar surface area: 58.9 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Hexane, 1,6-diisocyanatotrimethyl-1,6-DiisocyanatotrimethylhexaneEINECS 249-151-6RefChem:899837249-151-6Trimethylhexamethylene diisocyanateTRIMETHYL HEXAMETHYLENE DIISOCYANATEtrimethyl-1,6-diisocyanatohexane

4 more reported names

trimethyl-hexamethylene diisocyanateUN23281,6-diisocyanato-5,6-dimethyl-heptaneTrimethylhexamethylene diisocyanate [UN2328] [Poison]

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID60951342
PubMed:21374573
PubMed:20057942

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TRIMETHYLHEXAMETHYLENE DIISOCYANATE

INCI name

TRIMETHYLHEXAMETHYLENE DIISOCYANATE

Description

1,6-Diisocyanatotrimethylhexane,Hexane, 1,6-diisocyanatotrimethyl,TMDI,1,2,2-Trimethylhexamethylene Diisocyanate,2,2,4-Trimethylhexamethylene Diisocyanate,2,4,4-Trimethylhexamethylene Diisocyanate

Record provenance

Inventory reference: 95302
Imported identity: TRIMETHYLHEXAMETHYLENE DIISOCYANATE
Source update: 18/04/2018

European Commission CosIng source notes

Annex records for TRIMETHYLHEXAMETHYLENE DIISOCYANATE

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Key data

CAS

15646-96-5,28679-16-5

Restriction

—

Function

NOT REPORTED: No function currently reported.

Records sharing a CAS or EC identity

BANKSIA SERRATA SEED OIL COPAIFERA CORIACEA RESIN OIL COPAIFERA LANGSDORFFII RESIN OIL COPAIFERA RETICULATA RESIN OIL CYCLOHEXYL TOLUATE EREMOPHILA LONGIFOLIA LEAF EXTRACT HC BLUE NO. 18 LAURYL ASPARTIC ACID

Ingredients with overlapping formulation functions

TITANUM TETRA T-BUTOXIDENOT REPORTED

TOLUENE DIISOCYANATENOT REPORTED

TRIFLUOROMETHYL DEHYDROLATANOPROSTNOT REPORTED

TRIMELLITIC ANHYDRIDENOT REPORTED

TRIMETHYLOLPROPANE DIALLYL ETHERNOT REPORTED

TRIMETHYLOLPROPANE TRIS-MERCAPTOPROPIONATENOT REPORTED

TRIMETHYLPENTYL/METHOXY PEG-10 PROPYL POLYSILSESQUIOXANENOT REPORTED

TRIPEPTIDE-110NOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TRIMETHYLHEXAMETHYLENE DIISOCYANATE appears in the CosIng inventory

The CosIng inventory lists TRIMETHYLHEXAMETHYLENE DIISOCYANATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TRIMETHYLHEXAMETHYLENE DIISOCYANATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TRIMETHYLHEXAMETHYLENE DIISOCYANATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TRIMETHYLHEXAMETHYLENE DIISOCYANATE carries the following function designation(s):

NOT REPORTED

CAS 15646-96-5,28679-16-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TRIMETHYLHEXAMETHYLENE DIISOCYANATE

This page reproduces the CosIng inventory entry for TRIMETHYLHEXAMETHYLENE DIISOCYANATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TRIMETHYLHEXAMETHYLENE DIISOCYANATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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