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InventoryRef 9526826/04/2018

ETHYLENEDIAMINE

1,2-Diaminoethane,1,2-Ethanediamine

ETHYLENEDIAMINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

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MarketEvidence statusRecordsSource language
European UnionSource mapped
Inventory entry; no linked annex rule
0English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaEvidence linked
Prohibited
Open this evidence		1English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 107-15-3
CAS 107-15-3PubChem CID 3301

Ethylenediamine

Ethylenediamine is an alkane-alpha,-diamine in which the alkane is ethane. It has a role as a GABA agonist. It derives from a hydride of an ethane. — ChEBI

IUPAC name
ethane-1,2-diamine
Molecular formula
C2H8N2
Molecular weight
60.10 g/mol
Exact mass
60.068748264 Da
XLogP3
-2.0
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

1,2-Diaminoethane1,2-EthanediamineEthylene diamineEthylendiamineedamineDimethylenediamine1,2-EthylenediamineAethaldiamin
16 more reported names
AethylenediaminEthyleendiamineEthylene-diaminebeta-Aminoethylamine1,2-DiaminoaethanAlgicode 106LAmerstat 2741,2-Diamino-ethaan1,2-Diamino-ethanoNCI-C60402EPA Pesticide Chemical Code 00420560V9STC53FCHEBI:30347AI3-24231PB-05721Ethylenediamine (anhydrous)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:30347

ethylenediamine

An alkane-α,ω-diamine in which the alkane is ethane.

Formula
C2H8N2
Average mass
60.100 g/mol
Monoisotopic mass
60.06875 Da
Formal charge
0
  • alkane-α,ω-diamine — is a (CHEBI:35411)
  • GABA agonist — has role (CHEBI:51373)
  • antineoplastic agent — has role (CHEBI:35610)
  • ethane — has parent hydride (CHEBI:42266)
  • GABA agonist — has role (CHEBI:51373)
  • antineoplastic agent — has role (CHEBI:35610)
  • alkane-α,ω-diamine — is a (CHEBI:35411)
Additional curated names
ethane-1,2-diamine1,2-ethanediamineenethylenediamineEthylene diaminePB-05721PB05721
Cross-references from this source
  • CAS: 107-15-3 — NIST Chemistry WebBook
  • CAS: 107-15-3 — ChemIDplus
  • REGISTRY_NUMBER: 1098 — Gmelin
  • REGISTRY_NUMBER: 605263 — Reaxys
  • MANUAL_X_REF: CPD-3682 — MetaCyc
  • MANUAL_X_REF: D01114 — KEGG DRUG
  • MANUAL_X_REF: EDN — PDBeChem
  • MANUAL_X_REF: Ethylenediamine — Wikipedia
  • MANUAL_X_REF: HMDB0031225 — HMDB

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2016-02-16. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match3301

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Signs and Symptoms of Acute Ethylenediamine Exposure: Acute exposure to ethylenediamine may result in cough, difficulty in breathing, irritation of the lungs, and pneumonia. Nausea, vomiting, and diarrhea are often seen. Contact with ethylenediamine may result in redness, pain, irritation, and burns.; Emergency Life-Support Procedures: Acute exposure to ethylenediamine may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.; Inhalation Exposure:; 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to ethylenediamine.; 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.; 3. Obtain authorization and/or further instructions from the local h Source: CAMEO Chemicals
  • ERG2024, Guide 132 (Ethylenediamine): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P342+P316, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2078) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]; H302+H332 (11.5%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]; H302 (99.8%): Harmful if swallowed [Warning Acute toxicity, oral]; H311 (28.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H312 (73.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (> 99.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (38.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (27.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H334 (> 99.9%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H412 (49.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2078 reports by companies from 35 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 2078 reports by companies.; There are 34 notifications provided by 2077 of 2078 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P330, P333+P317, P342+P316, P361+P364, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of less than 1 was calculated for ethylenediamine(SRC), using a log Kow of -2.04(1)and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to have slight mobility in soil(SRC). Volatilization of ethylenediamine from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.73X10-9 atm-cu m/mole(3). The potential for volatilization of ethylenediamine from dry soil surfaces may exist based upon a vapor pressure of 12.1 mm Hg(4). However, adsorption to soil may attenuate volatilization(SRC). Based on screening studies(5-7), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in soil are available. Ethylenediamine may also form stable complexes with metal ions(8) in soil, but again, experimental data are lacking(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an average Koc value of 4766(2) indicates that ethylenediamine is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 1.73X10-9 atm-cu m/mole(4). As ethylenediamine has two primary amine groups, at the pH range found in most environmental waters, it is expected to be partially protonated; the dissociated form will not volatilize. According to a classification scheme(5), an estimated BCF of less than 1(SRC), from its log Kow(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. Based on screening studies(8-10), biodegradation is expected to be the most important degradation process for this compound but no experimental rates in water are available. Complexation of ethylenediamine with transition metals(11) in the water or reaction with humic materials(12) is possible(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylenediamine, which has a vapor pressure of 12.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor. Vapor-phase ethylenediamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6 hours(SRC), calculated from its rate constant of 6.3x10-11 cu cm/molecule-sec at 25 °C(3) using a structure estimation method(3). As ethylenediamine is miscible in water(4), washout by rain will also be an important removal process(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Chelating agent; Etching agent; Intermediate; Not Known or Reasonably Ascertainable; Plating agent; CBI; Other; Solvent Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used in the manufacture of chelating agents, fungicides, waxes, polyamide resins, and corrosion inhibitors. [ACGIH] Used as an emulsifier, an inhibitor in antifreeze solutions, and an additive to pharmaceuticals and textile lubricants; [Merck Index] Used in photography (color developing baths); [www.ci.tucson.az.us/arthazards/medium.html] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Photographic Processing [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For Ethylenediamine (USEPA/OPP Pesticide Code: 004205) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Solvent for casein, albumin, shellac, and sulfur; emulsifier; stabilizing rubber latex; as inhibitor in antifreeze solutions; in textile lubricants; pharmaceutic aid (aminophylline injection stabilizer) Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In prepn of dyes, synthetic waxes, resins, insecticides and asphalt wetting agents Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Use in manuf of weed killers; use in manuf of surfactants, emulsifying agents, wetting agents, dispersants, corrosion inhibitors, detergents, and textile surface treatments Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for ETHYLENEDIAMINE (8 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ETHYLENEDIAMINE

INCI name

ETHYLENEDIAMINE

Description

1,2-Diaminoethane,1,2-Ethanediamine

Record provenance

Inventory reference
95268
Imported identity
ETHYLENEDIAMINE
Source update
26/04/2018
European Commission CosIng source notes
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Key data

CAS
107-15-3
EC
203-468-6
Restriction
—
Function
NOT REPORTED
No function currently reported.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#10170 · ETHYLENEDIAMINE

Ingredients with overlapping formulation functions

EPOXIDIZED RAPESEED OILNOT REPORTED
EPSILON-CAPROLACTONENOT REPORTED
ERIOBOTRYA JAPONICA LEAF/TARAXACUM PLATYCARPUM EXTRACTNOT REPORTED
ETHYLENE DICHLORIDENOT REPORTED
FERRIC NITRATENOT REPORTED
FERROCENYLMETHYL METHACRYLATENOT REPORTED
FISH CARTILAGE EXTRACTNOT REPORTED
FISH EXTRACTNOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How ETHYLENEDIAMINE appears in the CosIng inventory

The CosIng inventory lists ETHYLENEDIAMINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ETHYLENEDIAMINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ETHYLENEDIAMINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ETHYLENEDIAMINE carries the following function designation(s):

CAS 107-15-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for ETHYLENEDIAMINE

This page reproduces the CosIng inventory entry for ETHYLENEDIAMINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ETHYLENEDIAMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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