Is VALPROIC ACID safe to use in EU cosmetics?

VALPROIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 99-66-1?

CAS 99-66-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains VALPROIC ACID?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9412623/06/2016

VALPROIC ACID

2-Propylpentanoic Acid

VALPROIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 99-66-1

CAS 99-66-1PubChem CID 3121

Valproic Acid

Valproic acid is a branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. It has a role as a psychotropic drug, an antimanic drug, an anticonvulsant, a teratogenic agent, a GABA agent, an EC 3.5.1.98 (histone deacetylase) inhibitor and a neuroprotective agent. It is a branched-chain fatty acid and a branched-chain saturated fatty acid. It is functionally related to a valeric acid. It is a conjugate acid of a valproate. — ChEBI

IUPAC name: 2-propylpentanoic acid

Molecular formula: C8H16O2
Molecular weight: 144.21 g/mol
Exact mass: 144.115029749 Da
XLogP3: 2.8
Topological polar surface area: 37.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

2-Propylvaleric acidDipropylacetic acidDepakeneDepakineMylproinDi-n-propylacetic acidPropylvaleric acidn-Dipropylacetic acid

16 more reported names

4-Heptanecarboxylic acidMyproic AcidConvulexn-DPAAcido valproicoAcide valproiqueDi-n-propylessigsaureStavzorKyselina 2-propylvalerovaAcidum valproicum2-n-Propyl-n-valeric acidAcetic acid, dipropyl-Epilim2-PROPYL-PENTANOIC ACIDValeric acid, 2-propyl-pentanoic acid, 2-propyl

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:39867
ChEMBL:CHEMBL109
EPA DTXSID:DTXSID6023733
PubMed:29339929
PubMed:28990289
PubMed:28032215
PubMed:25207925
PubMed:24132760
PubMed:23797677
PubMed:23120843
PubMed:23120787
PubMed:23118679
PubMed:23118657
PubMed:23113274
PubMed:23107221

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for VALPROIC ACID

INCI name

VALPROIC ACID

Description

2-Propylpentanoic Acid

Record provenance

Inventory reference: 94126
Imported identity: VALPROIC ACID
Source update: 23/06/2016

European Commission CosIng source notes

Annex records for VALPROIC ACID

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Key data

CAS

99-66-1

202-777-3

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29795 · VALPROIC ACID

Ingredients with overlapping formulation functions

VALERIANA OFFICINALIS RHIZOME/ROOT EXTRACTFRAGRANCE, SKIN CONDITIONING, SOOTHING

VALERIANA OFFICINALIS ROOT EXTRACTSKIN CONDITIONING

VALERIANA WALLICHII ROOT EXTRACTSKIN CONDITIONING

VALINEANTISTATIC, FRAGRANCE, HAIR CONDITIONING, SKIN CONDITIONING

VALPROOYL OLIGOPEPTIDE-33SKIN CONDITIONING

VANDA COERULEA FLOWER EXTRACTSKIN CONDITIONING

VANILLA PLANIFOLIA FLOWER EXTRACTSKIN CONDITIONING

VANILLA PLANIFOLIA FRUIT EXTRACTSKIN CONDITIONING, SKIN PROTECTING, SMOOTHING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How VALPROIC ACID appears in the CosIng inventory

The CosIng inventory lists VALPROIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

VALPROIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

VALPROIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, VALPROIC ACID carries the following function designation(s):

SKIN CONDITIONING

CAS 99-66-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for VALPROIC ACID

This page reproduces the CosIng inventory entry for VALPROIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research VALPROIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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