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InventoryRef 9204427/10/2014

MELITTIN

MELT

MELITTIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 20449-79-0
CAS 20449-79-0PubChem CID 16129627

Melitten

Melittin is the main component of bee venom. It is a powerful stimulator of phospholipase A2 and also exhibits potent anti-microbial activity. (L1014) Toxin and Toxin Target Database (T3DB)

IUPAC name
2-[[5-amino-2-[[2-[[6-amino-2-[[2-[[6-amino-2-[[2-[[2-[[2-[[2-[[2-[2-[[1-[2-[[2-[[2-[[2-[[2-[[2-[[6-amino-2-[[2-[[2-[2-[[2-[[2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]acetyl]amino]propanoylamino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]propanoylamino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]pentanediamide
Molecular formula
C131H229N39O31
Molecular weight
2846.5 g/mol
Exact mass
2845.7575265 Da
XLogP3
-2.7
Topological polar surface area
1150.0 Ų
Hydrogen-bond donors
41
Hydrogen-bond acceptors
37
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:925456Melittin IMellitinMelittin-TEINECS 253-417-7TOX-70001-PITP1299H-GIGAVLKVLTTGLPALISW IKRKRQQ-NH2
3 more reported names
LS-15546Melittin - CAS 37231-28-0 - CalbiochemH-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Se r-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for MELITTIN

INCI name

MELITTIN

Description

MELT

Record provenance

Inventory reference
92044
Imported identity
MELITTIN
Source update
27/10/2014
European Commission CosIng source notes

Key data

EC
Restriction
Function
ANTI-SEBUM
Helping control sebum production.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How MELITTIN appears in the CosIng inventory

The CosIng inventory lists MELITTIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

MELITTIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

MELITTIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, MELITTIN carries the following function designation(s):

CAS 20449-79-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for MELITTIN

This page reproduces the CosIng inventory entry for MELITTIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research MELITTIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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