Is MENAQUINONE-7 safe to use in EU cosmetics?

MENAQUINONE-7 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does MENAQUINONE-7 serve in cosmetics?

According to the EU CosIng inventory, MENAQUINONE-7 carries the following function designation(s): ANTI-SEBUM, ASTRINGENT, BLEACHING, SKIN PROTECTING, UV FILTER.

What other records share CAS 2124-57-4?

CAS 2124-57-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains MENAQUINONE-7?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9586727/04/2018

MENAQUINONE-7

MK-7,1,4-Naphthalenedione, 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaen-1-yl]-3-methyl-,Vitamin K2

MENAQUINONE-7 is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 2124-57-4

CAS 2124-57-4PubChem CID 5287554

Menaquinone 7

Menaquinone-7 is a menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation. It has a role as a Mycoplasma genitalium metabolite, a cofactor, a bone density conservation agent, an Escherichia coli metabolite and a human blood serum metabolite. — ChEBI

IUPAC name: 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methylnaphthalene-1,4-dione

Molecular formula: C46H64O2
Molecular weight: 649.0 g/mol
Exact mass: 648.49063128 Da
XLogP3: 14.5
Topological polar surface area: 34.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Menaquinone-7Vitamin K2(35)Menaquinone K7Vitamin MK 7Menakinon 72-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-dione8427BML8NY1,4-Naphthalenedione, 2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-, (all-E)-

16 more reported names

2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl]-3-methylnaphthalene-1,4-dioneCHEBI:442452-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-3-methylnaphthalene-1,4-dioneRefChem:925473Vitamin K2-7MK-7Menaquinone MK-7(all-E)-2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedioneMk7Menaquinone 7, Synthetic (90%)Menaquinone 7, Synthetic(all-E)-2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosahept-aenyl)-3-methyl-1,4-naphthoquinoneVitamin MK-7Menaquinone KMenlaquinone 7HSDB 1040

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:44245
ChEMBL:CHEMBL1230575
EPA DTXSID:DTXSID801317474
PubMed:31173816
PubMed:7601837

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for MENAQUINONE-7

INCI name

MENAQUINONE-7

Description

MK-7,1,4-Naphthalenedione, 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaen-1-yl]-3-methyl-,Vitamin K2

Record provenance

Inventory reference: 95867
Imported identity: MENAQUINONE-7
Source update: 27/04/2018

European Commission CosIng source notes

Annex records for MENAQUINONE-7

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Key data

CAS

2124-57-4

—

Restriction

—

Function

ANTI-SEBUM: Helping control sebum production.
ASTRINGENT: Contracting and/or tightening the skin.
BLEACHING: Bleaching or lightening the shade of hair and/or skin.
SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.
UV FILTER: Exclusively or mainly intended to protect the skin and/or hair against certain UV radiation by absorbing, reflecting or scattering UV radiation. All authorised UV filters are substances in the positive list of Annex VI to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16179 · MENAQUINONE-7

Ingredients with overlapping formulation functions

ISOAMYL PALMITATE/STEARATEHAIR CONDITIONING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, UV FILTER

LACTOBACILLUS/CAMELLIA SINENSIS CATECHINS/GELIDIUM CRINALE/LAMINARIA JAPONICA/M…ANTI-SEBUM, ANTIOXIDANT, SKIN CONDITIONING, UV FILTER

LIGNINANTIOXIDANT; COLORANT; OPACIFYING; UV ABSORBER; UV FILTER

LUPEYL ISONICOTINATEANTIOXIDANT, SKIN PROTECTING, UV FILTER

METHOXY PEG-3 DEHYDROCHOLESTERYL SUCCINATEANTIOXIDANT, HAIR CONDITIONING, UV FILTER

METHOXY PEG-7 DEHYDROCHOLESTERYL SUCCINATEANTIOXIDANT, HAIR CONDITIONING, UV FILTER

METHOXYCINNAMIC ACIDLIGHT STABILIZER, UV FILTER

METHOXYCINNAMIDOPROPYLDIMONIUM HYDROXYPROPYLSTEARDIMONIUM CHLORIDEUV FILTER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How MENAQUINONE-7 appears in the CosIng inventory

The CosIng inventory lists MENAQUINONE-7 as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

MENAQUINONE-7 is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

MENAQUINONE-7 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, MENAQUINONE-7 carries the following function designation(s):

CAS 2124-57-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for MENAQUINONE-7

This page reproduces the CosIng inventory entry for MENAQUINONE-7 from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research MENAQUINONE-7 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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