Is REBAUDIOSIDE A safe to use in EU cosmetics?

REBAUDIOSIDE A is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 58543-16-1?

CAS 58543-16-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains REBAUDIOSIDE A?

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InventoryRef 9173718/11/2014

REBAUDIOSIDE A

(4a)-13-[(2-O-ß-D-glucopyranosyl-3-O-ß-Dglucopyranosyl-ß-D-glucopyranosyl)-oxy]kaur-6-en-8-oic acid ß-Dglucopyranosyl ester

REBAUDIOSIDE A is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 58543-16-1

CAS 58543-16-1PubChem CID 6918840

Rebaudioside A

Rebaudioside A is a rebaudioside that is rubusoside in which the hydroxy groups at positions 3 and 4 of the beta-D-glucopyranosyloxy group at the 13alpha position have both been converted to the corresponding beta-D-glucopyranoside. It has a role as a sweetening agent. It is a rebaudioside and a beta-D-glucoside. It is functionally related to a rubusoside and a beta-D-Glcp-(1->2)-[beta-D-Glcp-(1->3)]-beta-D-Glcp. — ChEBI

IUPAC name: [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate

Molecular formula: C44H70O23
Molecular weight: 967.0 g/mol
Exact mass: 966.43078848 Da
XLogP3: -2.8
Topological polar surface area: 374.0 Å²
Hydrogen-bond donors: 14
Hydrogen-bond acceptors: 23
Covalent units: 1
Defined stereocentres: 26

Also known as

Stevioside A3TruviaRebaudioside-ARebianaRebaudiana aSweetener 4G-SReb-ASooolite!-Pure

16 more reported names

B3FUD0528FGlycoside XReb-A 97INS NO.960AINS-960A19-O-beta-glucopyranosyl-13-O-(beta-glucopyranosyl(1-2)-beta-glucopyranosyl(1-3))-beta-glucopyranosyl-13-hydroxykaur-16-en-19-oic acidFEMA NO. 4601CHEBI:145012E-960A19-O-beta-glucopyranosyl-13-O-(beta-glucopyranosyl(1-2)-beta-glucopyranosyl(1-3))-beta-glucopyranosylsteviolRefChem:47593Reb AREBAUDIOSIDEAChrysanta AR-PRA 95Stevia

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:145012
EPA DTXSID:DTXSID8047898
PubMed:40652992
PubMed:40334972
PubMed:34023281
PubMed:31655124
PubMed:30883860
PubMed:25554529
PubMed:23713723
PubMed:15610349

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for REBAUDIOSIDE A

INCI name

REBAUDIOSIDE A

Description

(4a)-13-[(2-O-ß-D-glucopyranosyl-3-O-ß-Dglucopyranosyl-ß-D-glucopyranosyl)-oxy]kaur-6-en-8-oic acid ß-Dglucopyranosyl ester

Record provenance

Inventory reference: 91737
Imported identity: REBAUDIOSIDE A
Source update: 18/11/2014

European Commission CosIng source notes

Annex records for REBAUDIOSIDE A

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Key data

CAS

58543-16-1

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#24088 · REBAUDIOSIDE A

Ingredients with overlapping formulation functions

RAVENALA MADAGASCARIENSIS ARIL EXTRACTSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

RAVENALA MADAGASCARIENSIS LEAF EXTRACTSKIN CONDITIONING

RAVENALA MADAGASCARIENSIS LEAF/STEM EXTRACTSKIN CONDITIONING

RAVENALA MADAGASCARIENSIS STEM EXTRACTSKIN CONDITIONING

RED JUNGLEFOWL BLASTODERM PLURIPOTENT CELL CULTURE CONDITIONED MEDIASKIN CONDITIONING

REHMANNIA CHINENSIS ROOT EXTRACTSKIN CONDITIONING, TONIC

REHMANNIA GLUTINOSA RHIZOME EXTRACTSKIN CONDITIONING

REHMANNIA GLUTINOSA ROOT EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How REBAUDIOSIDE A appears in the CosIng inventory

The CosIng inventory lists REBAUDIOSIDE A as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

REBAUDIOSIDE A is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

REBAUDIOSIDE A is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, REBAUDIOSIDE A carries the following function designation(s):

SKIN CONDITIONING

CAS 58543-16-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for REBAUDIOSIDE A

This page reproduces the CosIng inventory entry for REBAUDIOSIDE A from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research REBAUDIOSIDE A and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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