Is MIRODENAFIL safe to use in EU cosmetics?

MIRODENAFIL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 862189-95-5?

CAS 862189-95-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains MIRODENAFIL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9142328/10/2014

MIRODENAFIL

mirodenafil (INN),1-Piperazineethanol, 4-[[3-(5-ethyl-4,5-dihydro-4-oxo-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-2-yl)-4-propoxyphenyl]sulfonyl]-

MIRODENAFIL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 862189-95-5

CAS 862189-95-5PubChem CID 135497803

Mirodenafil

Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic Diseases, Renal Insufficiency, Erectile Dysfunction, and Male Erectile Dysfunction. — DrugBank

IUPAC name: 5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-3H-pyrrolo[3,2-d]pyrimidin-4-one

Molecular formula: C26H37N5O5S
Molecular weight: 531.7 g/mol
Exact mass: 531.25154047 Da
XLogP3: 2.2
Topological polar surface area: 125.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 8
Covalent units: 1
Defined stereocentres: 0

Also known as

mirodenafilomirodenafilumSK-3530SK3530 FREE BASE504G362H0HSK-3530 FREE BASECHEBI:1360495-ethyl-2-(5-(4-(2-hydroxyethyl)piperazine-1-sulfonyl)-2-propoxyphenyl)-7-propyl-3,5-dihydro-4H-pyrrolo(3,2-d)pyrimidin-4-one

16 more reported names

5-ETHYL-2-(5-((4-(2-HYDROXYETHYL)PIPERAZIN-1-YL)SULFONYL)-2-PROPOXYPHENYL)-7-PROPYL-3,5-DIHYDRO-4H-PYRROLO(3,2-D)PYRIMIDIN-4-ONE5-Ethyl-2-(5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)-2-propoxyphenyl)-7-propyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one5-ethyl-2-(5-(4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl-2-propoxyphenyl)-7-propyl-3H-pyrrolo(3,2-d)pyrimidin-4-one5-ethyl-2-(5-{[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl}-2-propoxyphenyl)-7-propyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one5-Ethyl-2-{5-[4-(2-hydroxyethyl)piperazine-1-sulfonyl]-2-propoxyphenyl}-7-propyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-oneRefChem:1590535-ethyl-2-(5-((4-(2-hydroxyethyl)piperazin-1-yl)sulfonyl)-2-propoxyphenyl)-7-propyl-3H,4H,5H-pyrrolo(3,2-d)pyrimidin-4-oneMirodenafil [INN]SK3530UNII-504G362H0HMvix5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-4-oneMIRODENAFIL [WHO-DD]MIJFNYMSCFYZNY-UHFFFAOYSA-NEX-A5487AR-1001

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:136049
ChEMBL:CHEMBL4297518
EPA DTXSID:DTXSID50881265
PubMed:33987996
PubMed:24872948
PubMed:22921287
PubMed:22692776
PubMed:22654729
PubMed:22259736
PubMed:22087063
PubMed:21905762
PubMed:21814227
PubMed:21790657
PubMed:21585174
PubMed:21478894

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for MIRODENAFIL

INCI name

MIRODENAFIL

Description

mirodenafil (INN),1-Piperazineethanol, 4-[[3-(5-ethyl-4,5-dihydro-4-oxo-7-propyl-1H-pyrrolo[3,2-d]pyrimidin-2-yl)-4-propoxyphenyl]sulfonyl]-

Record provenance

Inventory reference: 91423
Imported identity: MIRODENAFIL
Source update: 28/10/2014

European Commission CosIng source notes

Annex records for MIRODENAFIL

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Key data

CAS

862189-95-5

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16787 · MIRODENAFIL

Ingredients with overlapping formulation functions

MINOXIDIL SUCCINOYL OLIGOPEPTIDE-143SKIN CONDITIONING

MIRABILIS JALAPA CALLUS POWDERSKIN CONDITIONING

MIRABILIS JALAPA EXTRACTSKIN CONDITIONING, SKIN PROTECTING

MIRABILIS JALAPA FLOWER/LEAF/STEM EXTRACTSKIN CONDITIONING

MISCANTHUS SINENSIS EXTRACTSKIN CONDITIONING

MISCANTHUS SINENSIS FLOWER EXTRACTSKIN CONDITIONING

MITRACARPUS SCABER EXTRACTSKIN CONDITIONING

MIXED ISOPROPANOLAMINES LANOLATECLEANSING, HAIR CONDITIONING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How MIRODENAFIL appears in the CosIng inventory

The CosIng inventory lists MIRODENAFIL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

MIRODENAFIL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

MIRODENAFIL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, MIRODENAFIL carries the following function designation(s):

SKIN CONDITIONING

CAS 862189-95-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for MIRODENAFIL

This page reproduces the CosIng inventory entry for MIRODENAFIL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research MIRODENAFIL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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