Is NIPRADILOL safe to use in EU cosmetics?

NIPRADILOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 81486-22-8?

CAS 81486-22-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains NIPRADILOL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9142229/10/2014

NIPRADILOL

2H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1- methylethyl)amino)propoxy)-, 3-nitrate,Hypadil,nipradilol (INN)

NIPRADILOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 81486-22-8

CAS 81486-22-8PubChem CID 72006

Nipradilol

Hypadil (TN) is an organic molecular entity. — ChEBI

IUPAC name: [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl] nitrate

Molecular formula: C15H22N2O6
Molecular weight: 326.34 g/mol
Exact mass: 326.14778643 Da
XLogP3: 2.0
Topological polar surface area: 106.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 0

Also known as

NipradololHypadilNipradilolumFVM336I71YK-3518-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate2H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, 3-nitrateRefChem:927789

16 more reported names

3,4-dihydro-8-(2-hydroxy-3--isopropylaminopropoxy)-3-nitroxy-2H-1-benzopyranHypadil (TN)Hypadil; K 351; KT 210; Nipradilo8-(2-Hydroxy-3-(isopropylamino)propoxy)chroman-3-yl nitrate8-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-3,4-dihydro-2H-1-benzopyran-3-yl nitrateNipradilolum [Latin]NipranolNipradilol [INN:JAN]CCRIS 2515K 351BRN 3566879UNII-FVM336I71Y8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanyl nitratNIPRADILOL [MI]8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol 3-nitrateNipradilol (JAN/INN)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:31682
ChEMBL:CHEMBL155622
EPA DTXSID:DTXSID30868615

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NIPRADILOL

INCI name

NIPRADILOL

Description

2H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1- methylethyl)amino)propoxy)-, 3-nitrate,Hypadil,nipradilol (INN)

Record provenance

Inventory reference: 91422
Imported identity: NIPRADILOL
Source update: 29/10/2014

European Commission CosIng source notes

Annex records for NIPRADILOL

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Key data

CAS

81486-22-8

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17472 · NIPRADILOL

Ingredients with overlapping formulation functions

NIGELLA DAMASCENA COTYLEDON EXTRACTMOISTURISING, SKIN CONDITIONING

NIGELLA DAMASCENA SEED EXTRACTSKIN CONDITIONING

NIGELLA SATIVA SEED EXTRACTPERFUMING, SKIN CONDITIONING

NIGELLA SATIVA SEED OILPERFUMING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

NITROSOMONAS EUTROPHASKIN CONDITIONING

NOCARDIOIDES/PHYTOSTEROLS FERMENT EXTRACTHUMECTANT, SKIN CONDITIONING

NONANOYL TRYPTAMINESKIN CONDITIONING

NONAPEPTIDE-1HAIR CONDITIONING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NIPRADILOL appears in the CosIng inventory

The CosIng inventory lists NIPRADILOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NIPRADILOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NIPRADILOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NIPRADILOL carries the following function designation(s):

SKIN CONDITIONING

CAS 81486-22-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NIPRADILOL

This page reproduces the CosIng inventory entry for NIPRADILOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NIPRADILOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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