Is SYNEPHRINE safe to use in EU cosmetics?

SYNEPHRINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 94-07-5?

CAS 94-07-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains SYNEPHRINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 9062527/03/2014

SYNEPHRINE

4-[1-hydroxy-2-(methylamino)ethyl]phenol

SYNEPHRINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 94-07-5

CAS 94-07-5PubChem CID 7172

Synephrine

Synephrine is a phenethylamine alkaloid that is 4-(2-aminoethyl)phenol substituted by a hydroxy group at position 1 and a methyl group at the amino nitrogen. It has a role as an alpha-adrenergic agonist and a plant metabolite. It is a member of ethanolamines, a member of phenols and a phenethylamine alkaloid. It is a conjugate base of a synephrinium. — ChEBI

IUPAC name: 4-[1-hydroxy-2-(methylamino)ethyl]phenol

Molecular formula: C9H13NO2
Molecular weight: 167.20 g/mol
Exact mass: 167.094628657 Da
XLogP3: -0.6
Topological polar surface area: 52.5 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

Oxedrinep-SynephrineParasympatolAnaleptinSimpalonSympatolSynthenateSympathol

16 more reported names

EthapheneDL-SYNEPHRINE4-(1-Hydroxy-2-(methylamino)ethyl)phenolAdvantra z1-(4-Hydroxyphenyl)-2-methylaminoethanolNSC-166285NSC-170956PEG5DP7434CHEBI:29081beta-Methylamino-alpha-(4-hydroxyphenyl)ethyl alcohol1-(4-Hydroxyphenyl)-2-(methylamino)ethanolBenzenemethanol, 4-hydroxy-alpha-((methylamino)methyl)-4-Hydroxy-alpha-((methylamino)methyl)benzenemethanolp-Hydroxy-alpha-((methylamino)methyl)benzyl alcoholS-38537-9p-Hydroxy-alpha-[(methylamino)methyl]benzyl alcohol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:29081
ChEMBL:CHEMBL33720
EPA DTXSID:DTXSID0030588
PubMed:30155694
PubMed:28800181
PubMed:25111027
PubMed:24598981
PubMed:24487736
PubMed:22671857
PubMed:22592089
PubMed:22521485
PubMed:22471389
PubMed:22468825
PubMed:22465867
PubMed:22408069

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SYNEPHRINE

INCI name

SYNEPHRINE

Description

4-[1-hydroxy-2-(methylamino)ethyl]phenol

Record provenance

Inventory reference: 90625
Imported identity: SYNEPHRINE
Source update: 27/03/2014

European Commission CosIng source notes

Annex records for SYNEPHRINE

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Key data

CAS

94-07-5

—

Restriction

—

Function

SKIN PROTECTING: Helping to avoid harmful effects to the skin from external factors.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28156 · SYNEPHRINE

Ingredients with overlapping formulation functions

SUNFLOWERAMIDE AMPSKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - …

SUNFLOWERAMIDE MIPASKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - …

SUNFLOWERSEEDAMIDOPROPYL OLEATESKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT

SWEET ALMOND AMINO ACIDSHUMECTANT, SKIN PROTECTING

SYNSEPALUM DULCIFICUM SEED EXTRACTANTI-SEBORRHEIC; SKIN PROTECTING

SYRINGA OBLATA BARK/LEAF POWDERABRASIVE, FRAGRANCE, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

SYRINGA VULGARIS LEAF CELL EXTRACTANTIOXIDANT, SKIN PROTECTING

SYRINGA VULGARIS MERISTEM CELL CULTUREANTIOXIDANT, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SYNEPHRINE appears in the CosIng inventory

The CosIng inventory lists SYNEPHRINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SYNEPHRINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SYNEPHRINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SYNEPHRINE carries the following function designation(s):

SKIN PROTECTING

CAS 94-07-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SYNEPHRINE

This page reproduces the CosIng inventory entry for SYNEPHRINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SYNEPHRINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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