Is LAPACHONE safe to use in EU cosmetics?

LAPACHONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 4707-32-8?

CAS 4707-32-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains LAPACHONE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8881617/07/2012

LAPACHONE

2H-Naphthol[1,2-b]pyan-5,6-dione, 3,4-dihydro-2,2-dimethyl-

LAPACHONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 4707-32-8

CAS 4707-32-8PubChem CID 3885

Beta-Lapachone

Beta-lapachone is a benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities. It has a role as an antineoplastic agent, an anti-inflammatory agent and a plant metabolite. It is a member of orthoquinones and a benzochromenone. — ChEBI

IUPAC name: 2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione

Molecular formula: C15H14O3
Molecular weight: 242.27 g/mol
Exact mass: 242.094294304 Da
XLogP3: 2.2
Topological polar surface area: 43.4 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

lapachoneLapachone, beta-3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-B]pyran-5,6-dioneARQ 501Beta-lap-wjARQ-5013,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione6N4FA2QQ6A

16 more reported names

NSC-26326Beta lapachoneNSC-6297492H-Naphtho[1,2-b]pyran-5,6-dione, 3,4-dihydro-2,2-dimethyl-2H-Naphtho(1,2-b)pyran-5,6-dione, 3,4-dihydro-2,2-dimethyl-ARQ501CHEBI:104292,2-dimethyl-3,4-dihydrobenzo(h)chromene-5,6-dioneRefChem:5678932,2-Dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione.beta.-LapachoneNSC 26326SL 11001UNII-6N4FA2QQ6AARQ-501 (beta lapachone)NSC 629749

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:10429
ChEMBL:CHEMBL15192
EPA DTXSID:DTXSID90197019
PubMed:38218311
PubMed:37867446
PubMed:24552538
PubMed:22560901
PubMed:21830773
PubMed:21738692
PubMed:21637695
PubMed:21035436
PubMed:18227145
PubMed:15313406
PubMed:12538012
PubMed:8446597

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for LAPACHONE

INCI name

LAPACHONE

Description

2H-Naphthol[1,2-b]pyan-5,6-dione, 3,4-dihydro-2,2-dimethyl-

Record provenance

Inventory reference: 88816
Imported identity: LAPACHONE
Source update: 17/07/2012

European Commission CosIng source notes

Annex records for LAPACHONE

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Key data

CAS

4707-32-8

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Restriction

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Function

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Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#14867 · LAPACHONE

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How LAPACHONE appears in the CosIng inventory

The CosIng inventory lists LAPACHONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

Regulatory conditions, if any, come from Annex II–VI records and should be checked before use in a formulation.

Frequently asked questions

LAPACHONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

CAS 4707-32-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for LAPACHONE

This page reproduces the CosIng inventory entry for LAPACHONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research LAPACHONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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