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InventoryRef 8722115/10/2010

NITROPHENOL

NITROPHENOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 100-02-7
CAS 100-02-7PubChem CID 980

4-Nitrophenol

4-nitrophenol is a member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group. It has a role as a mouse metabolite and a human xenobiotic metabolite. It is a conjugate acid of a 4-nitrophenolate. — ChEBI

IUPAC name
4-nitrophenol
Molecular formula
C6H5NO3
Molecular weight
139.11 g/mol
Exact mass
139.026943022 Da
XLogP3
1.9
Topological polar surface area
66.1 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

p-nitrophenolPhenol, 4-nitro-ParanitrophenolNiphen4-Hydroxynitrobenzenep-Hydroxynitrobenzenepara-nitrophenolPhenol, p-nitro-
16 more reported names
ParanitrofenolParanitrofenolo4-NitrofenolNCI-C559921-Hydroxy-4-nitrobenzeneY92ZL45L4RCHEBI:16836NSC-13174-Hydroxy-1-nitrobenzeneRefChem:100077202-811-7Mononitrophenolp-NitrofenolRCRA waste number U170Caswell No. 603p-Nitrofenol [Czech]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:16836

4-nitrophenol

A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group.

Formula
C6H5NO3
Average mass
139.110 g/mol
Monoisotopic mass
139.02694 Da
Formal charge
0
  • 4-nitrophenols — is a (CHEBI:88306)
  • mouse metabolite — has role (CHEBI:75771)
  • human xenobiotic metabolite — has role (CHEBI:76967)
  • mouse metabolite — has role (CHEBI:75771)
  • human xenobiotic metabolite — has role (CHEBI:76967)
  • 4-nitrophenols — is a (CHEBI:88306)
  • 4-nitrophenolate — is conjugate acid of (CHEBI:57917)
Additional curated names
4-nitrophenol4-Hydroxynitrobenzene4-Nitrophenolp-hydroxynitrobenzeneNiphenparanitrophenolp-NitrophenolP-NITROPHENOLPNP
Cross-references from this source
  • CAS: 100-02-7 — ChemIDplus
  • CAS: 100-02-7 — KEGG COMPOUND
  • CAS: 100-02-7 — NIST Chemistry WebBook
  • REGISTRY_NUMBER: 1281877 — Reaxys
  • REGISTRY_NUMBER: 3311 — Gmelin
  • MANUAL_X_REF: 4-Nitrophenol — Wikipedia
  • MANUAL_X_REF: c0086 — UM-BBD
  • MANUAL_X_REF: C00870 — KEGG COMPOUND
  • MANUAL_X_REF: DB04417 — DrugBank
  • MANUAL_X_REF: HMDB0001232 — HMDB
  • MANUAL_X_REF: NPO — PDBeChem
  • MANUAL_X_REF: P-NITROPHENOL — MetaCyc

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2018-03-13. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match980

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P260, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P319, P321, P330, P362+P364, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (77.6%): Toxic if swallowed [Danger Acute toxicity, oral]; H302 (22.4%): Harmful if swallowed [Warning Acute toxicity, oral]; H312+H332 (42.3%): Harmful in contact with skin or if inhaled [Warning Acute toxicity, dermal; acute toxicity, inhalation]; H312 (99.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H332 (99.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H373 (99.2%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H412 (42.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P261, P264, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P317, P319, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 246 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P354+P338, P308+P316, P317, P319, P321, P330, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Nitrophenols may cause methemoglobinemia. This is a disorder in which there is an abnormally high level of methemoglobin in the blood, resulting in a decrease in the amount of oxygen that can be carried to the tissues and organs. (L1661, L1613) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: The nitrite in nitrophenols causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: BCF values of 2.5 to 7.8 were measured for carp (Carprinus carpio) exposed to 0.02 ppm and 0.2 ppm 4-nitrophenol over a 6-8 week incubation period(1). The BCF value of 4-nitrophenol was reported as 79 in fathead minnows(2) and 58 in golden orfe(3). According to a classification scheme(4), these BCF values suggest bioconcentration in aquatic organisms is low to moderate. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a median literature Koc value of 234 (log Koc = 2.37) reported for 4-nitrophenol(2) indicates that 4-nitrophenol is expected to have moderate mobility in soil(SRC). However, measured Koc values range from 16(3) to over 500(4) suggesting a range of very high mobility to low mobility(SRC). The pKa of 4-nitrophenol is 7.15(5), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). The available experimental data suggests 4-nitrophenol may be more mobile in anionic form(SRC). Volatilization of 4-nitrophenol from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 1.28X10-8 atm-cu m/mole(7). 4-Nitrophenol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 9.79X10-5 mm Hg at 20 °C(8). The biodegradation half-life of 4-nitrophenol in an acidic soil was reported as 2.5 days and the biodegradation half-life in a basic soil was reported as 10.2 days(9). However, a large number of biodegradatio Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a median literature Koc value of 234(2) indicates that 4-nitrophenol may undergo some adsorption to suspended solids and sediment in water(SRC). Measured Koc values range from 16(3) to over 500(4) suggesting a range of adsorption potential with sediment(SRC). The pKa of 4-nitropehnol is 7.15(5), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly than their neutral counterparts(6). Volatilization from water surfaces is not expected(7) based upon the Henry's Law constant of 1.28X10-8 atm-cu m/mole at 20 °C(8). According to a classification scheme(9), BCF values in the range of 2.5(10) to 79(11) in fish suggest bioconcentration in aquatic organisms will be low to moderate. 4-Nitrophenol is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(7). When 4-nitrophenol in water was exposed to sunlight, the half-life was 5.7, 6.7, and 13.7 days at pH 5, 7, and 9, respectively(12). The biodegradation half-life of 4-nitrophenol was reported as 18 hours and 6.8 days in aerobic and anaerobic waters, respectively(1 Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4-nitrophenol, which has a vapor pressure of 9.79X10-5 mm Hg at 20 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. An urban monitoring study in Rome Italy found the concentration to be higher in the particulate-phase compared to the vapor-phase(3). Vapor-phase 4-nitrophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3.7 days(SRC), calculated from its rate constant of 4.3X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(4). Particulate-phase 4-nitrophenol may be removed from the air by wet and dry deposition(SRC). Vapor-phase 4-nitrophenol is also removed from the ambient atmosphere through dissolution into cloud water with subsequent precipitation(5). 4-Nitrophenol absorbs UV light strongly above 290 nm(6) suggesting the compound is susceptible to direct photolysis in sunlight(SRC). 4-Nitrophenol adsorbed to silica gel was 39% mineralized when exposed to light greater tha Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 25154-55-6
CAS 25154-55-6CAS 88-75-5PubChem CID 6947

2-Nitrophenol

2-nitrophenol is a member of the class of 2-nitrophenols that is phenol in which one of the hydrogens that is ortho to the hydroxy group has been replaced by a nitro group. It is a conjugate acid of a 2-nitrophenolate. — ChEBI

IUPAC name
2-nitrophenol
Molecular formula
C6H5NO3
Molecular weight
139.11 g/mol
Exact mass
139.026943022 Da
XLogP3
1.8
Topological polar surface area
66.1 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

o-Nitrophenol88-75-52-HydroxynitrobenzenePhenol, 2-nitro-o-HydroxynitrobenzenePhenol, o-nitro-o-Nitrofenolortho-nitrophenol
16 more reported names
BD148E95KDNSC-1552CHEBI:16260RefChem:910143201-857-5NITROPHENOL2-nitro-phenolo-Nitrofenol [Czech]CAS-88-75-5CCRIS 2314HSDB 1133o-Nitrophenol (molten)NSC 1552EINECS 201-857-5UNII-BD148E95KDAI3-14893
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 554-84-7
CAS 554-84-7PubChem CID 11137

3-Nitrophenol

3-nitrophenol is a member of the class of 3-nitrophenols that is phenol in which one of the hydrogens that is meta to the hydroxy group has been replaced by a nitro group. — ChEBI

IUPAC name
3-nitrophenol
Molecular formula
C6H5NO3
Molecular weight
139.11 g/mol
Exact mass
139.026943022 Da
XLogP3
2.0
Topological polar surface area
66.1 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

M-NITROPHENOL3-HydroxynitrobenzenePhenol, 3-nitro-m-HydroxynitrobenzenePhenol, m-nitro-1-Hydroxy-3-nitrobenzeneCrump leather-lasting dressingT6P4T52V9W
16 more reported names
NSC-1551CHEBI:34346RefChem:504501209-073-5m-Nitrofenolmeta-Nitrophenol3-nitro-phenolNSC 1551m-Nitrofenol [Czech]CCRIS 2315HSDB 1337EINECS 209-073-5UNII-T6P4T52V9WAI3-088255-nitrophenol3-nitro phenol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NITROPHENOL

INCI name

NITROPHENOL

Record provenance

Inventory reference
87221
Imported identity
NITROPHENOL
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
88-75-5 / 100-02-7 / 554-84-7 / 25154-55-6
EC
201-857-5 / 202-811-7 / 209-073-5 / -
Restriction
—
Function
HAIR DYEING
Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17481 · NITROPHENOL

Ingredients with overlapping formulation functions

N-METHYL-3-NITRO-P-PHENYLENEDIAMINEHAIR DYEING
N-PHENYL-P-PHENYLENEDIAMINEHAIR DYEING
N-PHENYL-P-PHENYLENEDIAMINE HCLHAIR DYEING
N-PHENYL-P-PHENYLENEDIAMINE SULFATEHAIR DYEING
O-AMINOPHENOLHAIR DYEING
O-AMINOPHENOL SULFATEHAIR DYEING
P-AMINOPHENOLHAIR DYEING
P-AMINOPHENOL HCLHAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How NITROPHENOL appears in the CosIng inventory

The CosIng inventory lists NITROPHENOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NITROPHENOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NITROPHENOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NITROPHENOL carries the following function designation(s):

CAS 88-75-5 / 100-02-7 / 554-84-7 / 25154-55-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NITROPHENOL

This page reproduces the CosIng inventory entry for NITROPHENOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NITROPHENOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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