What other records share CAS 143-74-8?

CAS 143-74-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PHENOLSULFONPHTHALEIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8614115/10/2010

PHENOLSULFONPHTHALEIN

PHENOLSULFONPHTHALEIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 143-74-8

CAS 143-74-8PubChem CID 4766

Phenol Red

Phenol red is 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney. It has a role as a diagnostic agent, an acid-base indicator and a two-colour indicator. It is a member of phenols, a 2,1-benzoxathiole, a sultone and an arenesulfonate ester. — ChEBI

IUPAC name: 4-[3-(4-hydroxyphenyl)-1,1-dioxo-2,1lambda6-benzoxathiol-3-yl]phenol

Molecular formula: C19H14O5S
Molecular weight: 354.4 g/mol
Exact mass: 354.05619472 Da
XLogP3: 3.0
Topological polar surface area: 92.2 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

phenolsulfonphthaleinFenolipunaSulphonthalPSP (indicator)PhenolsulphonphthaleinNSC-10459I6G9Y0J1OJCHEBI:31991

16 more reported names

Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis-, (S,S-dioxide)3,3-bis(4-hydroxyphenyl)-3H-2,1??-benzoxathiole-1,1-dioneRefChem:1728812-(Bis(4-hydroxyphenyl)methyliumyl)benzenesulfonate205-609-7SulfonphthalSulphentalPhenolred3,3-Bis(4-hydroxyphenyl)-3H-benzo[c][1,2]oxathiole 1,1-dioxidePhenolsulfonephthaleinPhenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis-NSC 10459Phenol red solutionPhenol red indicatorC19H14O5S4,4'-(3H-2,1-Benzoxathiol-3-ylidene)diphenol S,S-dioxide

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:31991
ChEMBL:CHEMBL258921
EPA DTXSID:DTXSID8022408
PubMed:31629898
PubMed:31288001
PubMed:22571263
PubMed:22566767
PubMed:22463815
PubMed:22455001
PubMed:22419695
PubMed:22327900
PubMed:22300110
PubMed:22300109
PubMed:22246258
PubMed:22210102

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PHENOLSULFONPHTHALEIN

INCI name

PHENOLSULFONPHTHALEIN

Record provenance

Inventory reference: 86141
Imported identity: PHENOLSULFONPHTHALEIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PHENOLSULFONPHTHALEIN

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching PHENOLSULFONPHTHALEIN or related substances.

Key data

CAS

143-74-8

205-609-7

Restriction

—

Function

BUFFERING: Stabilising the pH of an aqueous medium in a narrow range even if an acid or base is added. Altering and/or maintaining a cosmetic product's pH at the desired level.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#20706 · PHENOLSULFONPHTHALEIN

Ingredients with overlapping formulation functions

MUDSTONE POWDERABRASIVE, BUFFERING

PAECILOMYCES JAPONICA/GRAPE/CUCUMBER JUICE EXTRACT FERMENT FILTRATEABSORBENT, ANTIOXIDANT, BUFFERING, SKIN PROTECTING

PENTAPOTASSIUM TRIPHOSPHATEBUFFERING, CHELATING

PENTASODIUM TRIPHOSPHATEBUFFERING, CHELATING

PHOSPHONOBUTANETRICARBOXYLIC ACIDANTICORROSIVE, BUFFERING, CHELATING

PHOSPHORIC ACIDBUFFERING

PHOSPHORUS PENTOXIDEBUFFERING, CHELATING

POLYGLYCERYL-25/CAPROLACTONEBUFFERING, FILM FORMING, HAIR CONDITIONING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYI…

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PHENOLSULFONPHTHALEIN appears in the CosIng inventory

The CosIng inventory lists PHENOLSULFONPHTHALEIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PHENOLSULFONPHTHALEIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PHENOLSULFONPHTHALEIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PHENOLSULFONPHTHALEIN carries the following function designation(s):

BUFFERING

CAS 143-74-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for PHENOLSULFONPHTHALEIN

This page reproduces the CosIng inventory entry for PHENOLSULFONPHTHALEIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PHENOLSULFONPHTHALEIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect PHENOLSULFONPHTHALEIN and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to PHENOLSULFONPHTHALEIN, its identifiers or nearby name variants.