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InventoryRef 8566609/12/2015

PALMITOYL HEXAPEPTIDE-12

Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-

PALMITOYL HEXAPEPTIDE-12 is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 171263-26-6
CAS 171263-26-6PubChem CID 10212452

Palmitoyl Hexapeptide-12

IUPAC name
2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-(hexadecanoylamino)-3-methylbutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid
Molecular formula
C38H68N6O8
Molecular weight
737.0 g/mol
Exact mass
736.50986315 Da
XLogP3
6.1
Topological polar surface area
203.0 Ų
Hydrogen-bond donors
6
Hydrogen-bond acceptors
8
Covalent units
1
Defined stereocentres
4

Also known as

HO4ZT5S86CPalmitoyl hexapeptide-12 [INCI]N-Palmitoyl-val-gly-val-ala-pro-glyGlycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-RefChem:858424Lipopeptide acetate2-((S)-1-((2S,5S,11S)-5,11-Diisopropyl-2-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctacosan-1-oyl)pyrrolidine-2-carboxamido)acetic acidC38H68N6O8
16 more reported names
N-(1-Oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolylglycineLipopeptideBiopeptide ElPalmitoyl hexapeptide 12Palmitoyl hexapeptide-12?UNII-HO4ZT5S86CJFSQSDAOQLNSQI-DTBJPNGVSA-NPalmitoyl Hexapeptide-12 (Powder)Palmitoyl Hexapeptide-12 (Liquid)DA-75030DS-11734HY-66015CS-0005655palmitoyl-L-valylglycyl-L-valyl-L-alanyl-L-prolylglycineN-Hexadecanoyl-L-valylglycyl-L-valyl-L-alanyl-L-prolylglycine2-((S)-1-((2S,5S,11S)-5,11-Diisopropyl-2-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctacosan-1-oyl)pyrrolidine-2-carboxamido)aceticacid
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

What the official INCI name states

The official label identifies a peptide- or protein-related cosmetic material.

Identity type from wording
peptide_or_protein

This structure is derived only from the official label wording. It does not establish composition, concentration, chemical equivalence, safety or regulatory permission.

Inventory details for PALMITOYL HEXAPEPTIDE-12

INCI name

PALMITOYL HEXAPEPTIDE-12

Description

Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-

Record provenance

Inventory reference
85666
Imported identity
PALMITOYL HEXAPEPTIDE-12
Source update
09/12/2015
European Commission CosIng source notes

Key data

EC
—
Restriction
—
Function
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How PALMITOYL HEXAPEPTIDE-12 appears in the CosIng inventory

The CosIng inventory lists PALMITOYL HEXAPEPTIDE-12 as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PALMITOYL HEXAPEPTIDE-12 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PALMITOYL HEXAPEPTIDE-12 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PALMITOYL HEXAPEPTIDE-12 carries the following function designation(s):

CAS 171263-26-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for PALMITOYL HEXAPEPTIDE-12

This page reproduces the CosIng inventory entry for PALMITOYL HEXAPEPTIDE-12 from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PALMITOYL HEXAPEPTIDE-12 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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