Is ESCULETIN safe to use in EU cosmetics?

ESCULETIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 305-01-1?

CAS 305-01-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains ESCULETIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8543015/10/2010

ESCULETIN

6,7-dihydroxy-2-benzopyrone

ESCULETIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 305-01-1

CAS 305-01-1PubChem CID 5281416

Esculetin

Esculetin is a hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light. It has a role as an antioxidant, an ultraviolet filter and a plant metabolite. — ChEBI

IUPAC name: 6,7-dihydroxychromen-2-one

Molecular formula: C9H6O4
Molecular weight: 178.14 g/mol
Exact mass: 178.02660867 Da
XLogP3: 1.2
Topological polar surface area: 66.8 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

6,7-DIHYDROXYCOUMARINAesculetin6,7-Dihydroxy-2H-chromen-2-oneCichorigeninCichoriin agluconEsculin agluconEsculin aglyconCichoriin aglycon

16 more reported names

6,7-Dihydroxy-2H-1-benzopyran-2-oneSM2XD6V944NSC-26428CHEBI:490095RefChem:137861206-161-5EsculetolEsculatin2H-1-Benzopyran-2-one, 6,7-dihydroxy-Asculetine6,7-Dihydroxy-2-benzopyroneC9H6O42,6-Dihydroxy-7H-chromen-7-oneCoumarin, 6,7-dihydroxy-NSC 264286,7-bis(oxidanyl)chromen-2-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:490095
ChEMBL:CHEMBL244743
EPA DTXSID:DTXSID3075383
EPA DTXSID:DTXSID801293090
PubMed:38567888
PubMed:31313495
PubMed:31163215
PubMed:30171828
PubMed:28946194
PubMed:27769711
PubMed:26388407
PubMed:24995577
PubMed:24685503
PubMed:24176340
PubMed:22999477
PubMed:22870812

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ESCULETIN

INCI name

ESCULETIN

Description

6,7-dihydroxy-2-benzopyrone

Record provenance

Inventory reference: 85430
Imported identity: ESCULETIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for ESCULETIN

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Key data

CAS

305-01-1

206-161-5

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9988 · ESCULETIN

Ingredients with overlapping formulation functions

ESCHERICHIA COLI EXTRACTSKIN CONDITIONING

ESCHERICHIA COLI/GLUCOSE FERMENT FILTRATESKIN CONDITIONING

ESCHSCHOLZIA CALIFORNICA FLOWER/LEAF/STEM EXTRACTSKIN CONDITIONING

ESCHSCHOLZIA CALIFORNICA LEAF EXTRACTSKIN CONDITIONING

ESTRADIOLSKIN CONDITIONING

ETHANOLAMINE GLYCEROPHOSPHATESKIN CONDITIONING

ETHINYLESTRADIOLSKIN CONDITIONING

ETHOXYHEPTYL BICYCLOOCTANONESKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ESCULETIN appears in the CosIng inventory

The CosIng inventory lists ESCULETIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ESCULETIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ESCULETIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ESCULETIN carries the following function designation(s):

SKIN CONDITIONING

CAS 305-01-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ESCULETIN

This page reproduces the CosIng inventory entry for ESCULETIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ESCULETIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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