Is OSTHOLE safe to use in EU cosmetics?

OSTHOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 484-12-8?

CAS 484-12-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains OSTHOLE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8542815/10/2010

OSTHOLE

OSTHOLE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 484-12-8

CAS 484-12-8PubChem CID 10228

Osthol

Osthole is a natural product found in Peucedanum ostruthium and Angelica pubescens. It has a role as a metabolite. It is a member of coumarins and a botanical anti-fungal agent. — ChEBI

IUPAC name: 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one

Molecular formula: C15H16O3
Molecular weight: 244.28 g/mol
Exact mass: 244.109944368 Da
XLogP3: 3.8
Topological polar surface area: 35.5 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

OstholeOstoleOstol2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)-7-Methoxy-8-isopentenylcoumarin8-(3-Methyl-2-butenyl)herniarin7-METHOXY-8-(3-METHYL-2-BUTENYL)-COUMARINXH1TI1759C

16 more reported names

NSC-318687-METHOXY-8-(3-METHYLBUT-2-ENYL)-2-CHROMENONERefChem:436167-methoxy-8-(3-methylpent-2-enyl)coumarin610-421-77-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one7-methoxy-8-(3-methyl-2-buten-1-yl)-2H-chromen-2-one7-methoxy-8-(3-methyl-2-butenyl)coumarinNSC 31868Coumarin, 7-methoxy-8-(3-methyl-2-butenyl)-UNII-XH1TI1759COsthole CRSA0O7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-oneOsthole (Standard)7-methoxy-8-(3-methyl-2-butenyl)-2h-1-benzopyran-2-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:69832
ChEMBL:CHEMBL52229
EPA DTXSID:DTXSID20197507
PubMed:40913911
PubMed:40446951
PubMed:39793773
PubMed:37769856
PubMed:32020584
PubMed:31870840
PubMed:30108138
PubMed:29319219
PubMed:24244343
PubMed:23603464
PubMed:22942756
PubMed:22923177

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for OSTHOLE

INCI name

OSTHOLE

Record provenance

Inventory reference: 85428
Imported identity: OSTHOLE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for OSTHOLE

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Key data

CAS

484-12-8

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#18483 · OSTHOLE

Ingredients with overlapping formulation functions

OSMANTHUS FRAGRANS EXTRACTSKIN CONDITIONING

OSMANTHUS FRAGRANS LEAF EXTRACTHUMECTANT, SKIN CONDITIONING

OSMANTHUS INSULARIS LEAF EXTRACTSKIN CONDITIONING

OSTERICUM KOREANUM EXTRACTSKIN CONDITIONING

OSTREA EDULIS EXTRACTSKIN CONDITIONING

OSTRICH EGG YOLK EXTRACTANTIMICROBIAL, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

OSTRICH OILHAIR CONDITIONING, SKIN CONDITIONING

OSTRYA JAPONICA LEAF EXTRACTANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How OSTHOLE appears in the CosIng inventory

The CosIng inventory lists OSTHOLE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

OSTHOLE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

OSTHOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, OSTHOLE carries the following function designation(s):

SKIN CONDITIONING

CAS 484-12-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for OSTHOLE

This page reproduces the CosIng inventory entry for OSTHOLE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research OSTHOLE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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