Is ACETYL PROLINE safe to use in EU cosmetics?

ACETYL PROLINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 68-95-1?

CAS 68-95-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8515115/10/2010

ACETYL PROLINE

1-acetyl-L-proline

ACETYL PROLINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 68-95-1

CAS 68-95-1PubChem CID 66141

N-Acetyl-L-proline

N-acetyl-L-proline is a N-acetyl-L-amino acid, a pyrrolidinemonocarboxylic acid, a N-acylpyrrolidine and a L-proline derivative. — ChEBI

IUPAC name: (2S)-1-acetylpyrrolidine-2-carboxylic acid

Molecular formula: C7H11NO3
Molecular weight: 157.17 g/mol
Exact mass: 157.07389321 Da
XLogP3: -0.7
Topological polar surface area: 57.6 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 1

Also known as

1-Acetyl-L-prolineAcetyl prolineL-Proline, 1-acetyl-(S)-1-acetylpyrrolidine-2-carboxylic acidProline, 1-acetyl-, L-(s)-n-acetylprolineCC8XZ138VZ(S)-(-)-N-acetylproline

16 more reported names

CHEBI:21560NSC-280718RefChem:552461200-698-9Ac-Pro-OHN-AcetylprolineAcetylprolineAcetyl-L-Proline(S)-1-Acetyl-pyrrolidine-2-carboxylic acidacetyl-proline4avs1-Acetylproline #DL-Proline, 1-acetyl-EN300-211779N7PUNII-CC8XZ138VZ

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:21560
ChEMBL:CHEMBL1234599
EPA DTXSID:DTXSID00910312
PubMed:22044351
PubMed:21950856
PubMed:21840115
PubMed:21458447
PubMed:21458445
PubMed:21458443
PubMed:21249198
PubMed:20599927
PubMed:20448817
PubMed:19865525
PubMed:19762563
PubMed:19757781

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ACETYL PROLINE

INCI name

ACETYL PROLINE

Description

1-acetyl-L-proline

Record provenance

Inventory reference: 85151
Imported identity: ACETYL PROLINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for ACETYL PROLINE

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Key data

CAS

68-95-1

200-698-9

Restriction

—

Function

SKIN CONDITIONING - EMOLLIENT: Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#702 · ACETYL PROLINE

Ingredients with overlapping formulation functions

ACETYL HISTIDINEHUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

ACETYL HYDROGENATED CITRONELLOL/GERANIOL/NEROL COPOLYMERFILM FORMING, FRAGRANCE, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

ACETYL HYDROXYPROLINEHAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

ACETYL ISOOCTYL POLYRICINOLEATESKIN CONDITIONING - EMOLLIENT; SKIN CONDITIONING - MISCELLANEOUS; SKIN CONDITIONING - OCCLUSIVE

ACETYL PROLYL HYDROXYPROLINESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

ACETYL S-HELIANTHUS ANNUUS HEXAPEPTIDE-1 AMIDESKIN CONDITIONING - EMOLLIENT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT; SKIN CONDITIONING - …

ACETYL S-SILKWORM OLIGOPEPTIDE-1 SP AMIDEANTI-SEBUM, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

ACETYL SH-OLIGOPEPTIDE-26 SH-OLIGOPEPTIDE-27 SPSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ACETYL PROLINE appears in the CosIng inventory

The CosIng inventory lists ACETYL PROLINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ACETYL PROLINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ACETYL PROLINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ACETYL PROLINE carries the following function designation(s):

SKIN CONDITIONING - EMOLLIENT

CAS 68-95-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ACETYL PROLINE

This page reproduces the CosIng inventory entry for ACETYL PROLINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ACETYL PROLINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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