What function does ACETYL HISTIDINE serve in cosmetics?

According to the EU CosIng inventory, ACETYL HISTIDINE carries the following function designation(s): HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT.

How do I check if my formula contains ACETYL HISTIDINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5413615/10/2010

ACETYL HISTIDINE

L-Histidine, N-Acetyl-,

ACETYL HISTIDINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 39145-52-3

CAS 39145-52-3PubChem CID 2724380

N-acetylhistidine monohydrate

The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Acetyl Histidine — Cosmetic Ingredient Review (CIR)

IUPAC name: (2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoic acid;hydrate

Molecular formula: C8H13N3O4
Molecular weight: 215.21 g/mol
Exact mass: 215.09060590 Da
Topological polar surface area: 96.1 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 5
Covalent units: 2
Defined stereocentres: 1

Also known as

Acetyl histidineN-Acetyl-L-histidine hydrateL-Histidine, N-acetyl-, monohydrateL-N-acetylhistidine monohydratePQ2TC3X11ORefChem:199350ac-his-oh.h2oN-Acetyl-L-histidine Monohydrate

16 more reported names

Ac-His-OH H2ON-Acetyl-L-histidine (monohydrate)(2S)-2-(Acetylamino)-3-(1H-imidazol-4-yl)propanoic acid hydrateN-Acetyl-L-histidine MonohydrateUNII-PQ2TC3X11OAc-L-His-OH.H2Oacetylhistidine monohydrateacetyl-L-histidine hydratePSWSDQRXCOJSFC-FJXQXJEOSA-N(2S)-2-ACETAMIDO-3-(1H-IMIDAZOL-4-YL)PROPANOIC ACID HYDRATECS-W014896HY-W014180AS-49156EN300-198771L-HISTIDINE, N-ACETYL-, HYDRATE (1:1)(2S)-2-(acetylamino)-3-imidazol-4-ylpropanoic acid, hydrate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID901021292

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ACETYL HISTIDINE

INCI name

ACETYL HISTIDINE

Description

L-Histidine, N-Acetyl-,

Record provenance

Inventory reference: 54136
Imported identity: ACETYL HISTIDINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for ACETYL HISTIDINE

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Key data

CAS

2407-02-1 / 39145-52-3

219-678-6 / -

Restriction

—

Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN CONDITIONING - EMOLLIENT: Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#666 · ACETYL HISTIDINE

Ingredients with overlapping formulation functions

ACETYL GALACTOSAMINEHUMECTANT, SKIN CONDITIONING

ACETYL GLUCOSAMINE ETHYL ETHERHUMECTANT, SKIN CONDITIONING

ACETYL HEPTAPEPTIDE-4HUMECTANT, SKIN CONDITIONING

ACETYL HEXAPEPTIDE-8HUMECTANT, SKIN CONDITIONING

ACETYL HYDROXYPROLINEHAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

ACETYL OCTAPEPTIDE-3HUMECTANT, SKIN CONDITIONING

ACETYL SH-PENTAPEPTIDE-14 SP AMIDEHUMECTANT; SKIN PROTECTING

ACETYL TETRAPEPTIDE-5HUMECTANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ACETYL HISTIDINE appears in the CosIng inventory

The CosIng inventory lists ACETYL HISTIDINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ACETYL HISTIDINE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ACETYL HISTIDINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ACETYL HISTIDINE carries the following function designation(s):

CAS 2407-02-1 / 39145-52-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ACETYL HISTIDINE

This page reproduces the CosIng inventory entry for ACETYL HISTIDINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ACETYL HISTIDINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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