What does the restriction note for BARIUM GLUCONATE mean?

The restriction field for BARIUM GLUCONATE reads: II/46. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 22561-74-6?

CAS 22561-74-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains BARIUM GLUCONATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8501315/10/2010

BARIUM GLUCONATE

Barium di-D-gluconate

BARIUM GLUCONATE is linked to 1 EU annex record on this page. Inventory note: II/46.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 22561-74-6

CAS 22561-74-6PubChem CID 89753

Barium gluconate

IUPAC name: barium(2+);bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)

Molecular formula: C12H22BaO14
Molecular weight: 527.62 g/mol
Exact mass: 528.006202 Da
Topological polar surface area: 283.0 Å²
Hydrogen-bond donors: 10
Hydrogen-bond acceptors: 14
Covalent units: 3
Defined stereocentres: 8

Also known as

D-Gluconic acid, barium saltBarium di-D-gluconateEINECS 245-081-5NSC-1945Barium di(D-gluconate)UNII-C23395US5PTox21_110002CAS-5328-41-6

2 more reported names

D-GLUCONIC ACID, BARIUM SALT (2:1)GLUCONIC ACID, BARIUM SALT (2:1), D-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL3182297
EPA DTXSID:DTXSID7045079

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BARIUM GLUCONATE

INCI name

BARIUM GLUCONATE

Description

Barium di-D-gluconate

Record provenance

Inventory reference: 85013
Imported identity: BARIUM GLUCONATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for BARIUM GLUCONATE

Annex II Restriction reference

Entry 46

Barium salts, with the exception of barium sulphide under the conditions laid down in Annex III and…

Key data

CAS

22561-74-6

245-081-5

Restriction

II/46

Function

NOT REPORTED: No function currently reported.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#3039 · BARIUM GLUCONATE

Ingredients with overlapping formulation functions

ASPERGILLUS/TANNIC ACID FERMENT EXTRACTNOT REPORTED

AZIRIDINENOT REPORTED

BACILLUS EXTRACTNOT REPORTED

BARIUM CHLORIDENOT REPORTED

BARIUM HEXAFERRITENOT REPORTED

BEHENETH-25 METHACRYLATENOT REPORTED

BEHENYL ACRYLATENOT REPORTED

BENZIMIDAZOLENOT REPORTED

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How BARIUM GLUCONATE appears in the CosIng inventory

The CosIng inventory lists BARIUM GLUCONATE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BARIUM GLUCONATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BARIUM GLUCONATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for BARIUM GLUCONATE reads: "II/46". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, BARIUM GLUCONATE carries the following function designation(s):

NOT REPORTED

CAS 22561-74-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for BARIUM GLUCONATE

This page combines the CosIng inventory entry for BARIUM GLUCONATE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research BARIUM GLUCONATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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