Is MATRINE safe to use in EU cosmetics?

MATRINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 519-02-8?

CAS 519-02-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8389315/10/2010

MATRINE

1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]Naphthyridin-10-one, Dodecahydro-, (7aS,13aR,13bR,13cS)-

MATRINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 519-02-8

CAS 519-02-8PubChem CID 91466

Matrine

Matrine is an alkaloid. — ChEBI

IUPAC name: (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one

Molecular formula: C15H24N2O
Molecular weight: 248.36 g/mol
Exact mass: 248.188863393 Da
XLogP3: 1.6
Topological polar surface area: 23.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 4

Also known as

(+)-MatrineVegardN390W430ACNSC-146051NSC-318810(1R,2R,9S,17S)-7,13-diazatetracyclo(7.7.1.02,7.013,17)heptadecan-6-oneRefChem:555562,6-diamino-5-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl)oxy-1H-pyrimidin-4-one

16 more reported names

7,13-diazatetracyclo(7.7.1.02,7.013,17)heptadecan-6-oneEx Sophporae Radix(7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-oneMatrene, (+)-(41S,7aS,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10(41H)-oneAlpha MatrineC15H24N2OCHEBI:6700.alpha.-MatrineNSC 146051BRN 0085851LupanidineUNII-N390W430ACMatrine CRSMatrine (Standard)Matridin-15-one;

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:6700
ChEMBL:CHEMBL204860
EPA DTXSID:DTXSID00274188
PubMed:28969577
PubMed:23092573
PubMed:23056487
PubMed:22988474
PubMed:22969826
PubMed:22932217
PubMed:22832383
PubMed:22782478
PubMed:22779183
PubMed:22775214
PubMed:22705561
PubMed:22695694

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for MATRINE

INCI name

MATRINE

Description

1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]Naphthyridin-10-one, Dodecahydro-, (7aS,13aR,13bR,13cS)-

Record provenance

Inventory reference: 83893
Imported identity: MATRINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for MATRINE

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Key data

CAS

519-02-8

—

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16040 · MATRINE

Ingredients with overlapping formulation functions

MANGANESE QUINOLYLMETHYLAMINOETHYL PYRIDINYLTRIAZACYCLODODECANEANTIOXIDANT

MARTYNOSIDEANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

MASLINIC ACIDANTIOXIDANT, SKIN CONDITIONING

MATRICARIA MARITIMA EXTRACTANTIOXIDANT, SKIN CONDITIONING

MATTEUCCIA STRUTHIOPTERIS EXTRACTANTIOXIDANT, SKIN CONDITIONING

MATTHIOLA INCANA CALLUS CULTURE EXTRACTANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

MAYAMAEA PERMITIS CULTURE CONDITIONED MEDIAANTIOXIDANT

MAYAMAEA PERMITIS EXTRACTANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How MATRINE appears in the CosIng inventory

The CosIng inventory lists MATRINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

MATRINE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

MATRINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, MATRINE carries the following function designation(s):

CAS 519-02-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for MATRINE

This page reproduces the CosIng inventory entry for MATRINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research MATRINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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