Is TAZAROTENE safe to use in EU cosmetics?

TAZAROTENE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 118292-40-3?

CAS 118292-40-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains TAZAROTENE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8379915/10/2010

TAZAROTENE

3-Pyridinecarboxylic Acid, 6-[(3,4-Dihydro-4,4-Dimethyl-2H-1-Benzothiopyran-6-yl)Ethynyl]-, Ethyl Ester

TAZAROTENE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 118292-40-3

CAS 118292-40-3PubChem CID 5381

Tazarotene

Tazarotene is the ethyl ester of tazarotenic acid. A prodrug for tazarotenic acid, it is used for the treatment of psoriasis, acne, and sun-damaged skin. It has a role as a keratolytic drug, a prodrug and a teratogenic agent. It is an ethyl ester, a member of pyridines, a retinoid, a thiochromane and an acetylenic compound. It is functionally related to a tazarotenic acid. — ChEBI

IUPAC name: ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate

Molecular formula: C21H21NO2S
Molecular weight: 351.5 g/mol
Exact mass: 351.12930009 Da
XLogP3: 4.9
Topological polar surface area: 64.5 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

TazoracEthyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinateZoracAvageAGN-190168Fabiortazarotenotazarotenum

16 more reported names

Idp-12381BDR9Y8PSARAZLODUOBRII COMPONENT TAZAROTENE3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl esterCHEBI:32184ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinateethyl 6-[2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]pyridine-3-carboxylateethyl 6-[(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinateTazaratoneTazarodexEthyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinateethyl 6-(2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl)pyridine-3-carboxylateethyl 6-(2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl)pyridine-3-carboxylatePSO THERARefChem:58033

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:32184
ChEMBL:CHEMBL1657
EPA DTXSID:DTXSID5046691
PubMed:28551711
PubMed:22828167
PubMed:22777233
PubMed:22704345
PubMed:22472354
PubMed:22457602
PubMed:22427797
PubMed:22389863
PubMed:22363853
PubMed:22359626
PubMed:22351815
PubMed:22272266

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match5381

Attributed physical-property, hazard, environmental and use annotations.

LogP: 5.6 Source: DrugBank
LogP: 5.6 Source: Human Metabolome Database (HMDB)

Physical Description: Solid Source: Human Metabolome Database (HMDB)

Solubility: Soluble Source: DrugBank
Solubility: 7.50e-04 g/L Source: Human Metabolome Database (HMDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TAZAROTENE

INCI name

TAZAROTENE

Description

3-Pyridinecarboxylic Acid, 6-[(3,4-Dihydro-4,4-Dimethyl-2H-1-Benzothiopyran-6-yl)Ethynyl]-, Ethyl Ester

Record provenance

Inventory reference: 83799
Imported identity: TAZAROTENE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TAZAROTENE

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Key data

CAS

118292-40-3

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28343 · TAZAROTENE

Ingredients with overlapping formulation functions

TAXODIUM DISTICHUM EXTRACTANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

TAXUS (MEDIA/CUSPIDATA/BREVIFOLIA/BACCATA/CANADENSIS) MERISTEM CELL CULTURE CON…ANTIMICROBIAL, ANTIOXIDANT, SKIN CONDITIONING

TAXUS CUSPIDATA EXTRACTSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

TAXUS CUSPIDATA LEAF EXTRACTSKIN CONDITIONING

TEA-ABIETOYL HYDROLYZED COLLAGENANTISTATIC, CLEANSING, HAIR CONDITIONING, SKIN CONDITIONING, SKIN PROTECTING, SURFACTANT - CLEANSING

TEA-C8-18 PERFLUOROALKYLETHYL PHOSPHATEHAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING

TEA-COCOYL HYDROLYZED COLLAGENANTISTATIC, CLEANSING, HAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING

TEA-COCOYL HYDROLYZED SOY PROTEINANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TAZAROTENE appears in the CosIng inventory

The CosIng inventory lists TAZAROTENE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TAZAROTENE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TAZAROTENE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TAZAROTENE carries the following function designation(s):

SKIN CONDITIONING

CAS 118292-40-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TAZAROTENE

This page reproduces the CosIng inventory entry for TAZAROTENE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TAZAROTENE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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