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InventoryRef 8288215/10/2010

NAPROXEN

(+)-(S)-6-Methoxy-a-Methyl-2-Naphthaleneacetic Acid

NAPROXEN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 22204-53-1
CAS 22204-53-1PubChem CID 156391

Naproxen

Naproxen is a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a xenobiotic, a gout suppressant, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an environmental contaminant and a drug allergen. It is a monocarboxylic acid and a methoxynaphthalene. It is a conjugate acid of a naproxen(1-). — ChEBI

IUPAC name
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
Molecular formula
C14H14O3
Molecular weight
230.26 g/mol
Exact mass
230.094294304 Da
XLogP3
3.3
Topological polar surface area
46.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
1

Also known as

(S)-Naproxen(+)-NaproxenEquiproxenNaprosynNaproxene(S)-(+)-Naproxend-NaproxenNycopren
16 more reported names
NaixanEc-Naprosyn(+)-(S)-Naproxen(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acidLaraflexNaprosyneNaproxenoNaproxenumCalosenNapriusReuxenBonylNaxenAxerVeradolXenar
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NAPROXEN

INCI name

NAPROXEN

INN name

Naproxen [USAN:INN:BAN:JAN]

Description

(+)-(S)-6-Methoxy-a-Methyl-2-Naphthaleneacetic Acid

Record provenance

Inventory reference
82882
Imported identity
NAPROXEN
Source update
15/10/2010
European Commission CosIng source notes

Key data

Restriction
—
Function
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How NAPROXEN appears in the CosIng inventory

The CosIng inventory lists NAPROXEN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NAPROXEN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NAPROXEN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NAPROXEN carries the following function designation(s):

CAS 22204-53-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for NAPROXEN

This page reproduces the CosIng inventory entry for NAPROXEN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NAPROXEN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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