Is ISOPROPYL PCA safe to use in EU cosmetics?

ISOPROPYL PCA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 85136-11-4?

CAS 85136-11-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains ISOPROPYL PCA?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8252115/10/2010

ISOPROPYL PCA

Proline, 5-Oxo-, 1-Methylethyl Ester

ISOPROPYL PCA is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 85136-11-4

CAS 85136-11-4PubChem CID 97590

Isopropyl 5-oxo-DL-prolinate

IUPAC name: propan-2-yl 5-oxopyrrolidine-2-carboxylate

Molecular formula: C8H13NO3
Molecular weight: 171.19 g/mol
Exact mass: 171.08954328 Da
XLogP3: 0.4
Topological polar surface area: 55.4 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

ISOPROPYL 5-OXOPYRROLIDINE-2-CARBOXYLATEDL-Pyroglutamic acid isopropyl esterNSC-134259EINECS 285-734-1isopropyl 2-pyrrolidone-5-carboxylatePropan-2-yl 5-hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID401005554

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ISOPROPYL PCA

INCI name

ISOPROPYL PCA

Description

Proline, 5-Oxo-, 1-Methylethyl Ester

Record provenance

Inventory reference: 82521
Imported identity: ISOPROPYL PCA
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for ISOPROPYL PCA

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Key data

CAS

85136-11-4

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Restriction

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Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#13861 · ISOPROPYL PCA

Ingredients with overlapping formulation functions

IRIS SIBIRICA ROOT EXTRACTHAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

ISOMALTHUMECTANT

ISOMALTOOLIGOSACCHARIDEHUMECTANT; SKIN PROTECTING

ISOPOLYGLYCERYL-3 DIMETHICONECLEANSING, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTA…

ISOSORBIDEHUMECTANT, SKIN CONDITIONING

ISOSORBIDE DISUNFLOWERSEEDATEHUMECTANT, PLASTICISER, SKIN CONDITIONING

ISOSTEARYL PCAHUMECTANT, SKIN CONDITIONING - EMOLLIENT

ISOTRIACONTANEANTIOXIDANT, ASTRINGENT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING - EMOLLIENT, SKIN CONDITIO…

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ISOPROPYL PCA appears in the CosIng inventory

The CosIng inventory lists ISOPROPYL PCA as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ISOPROPYL PCA is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ISOPROPYL PCA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ISOPROPYL PCA carries the following function designation(s):

HUMECTANT

CAS 85136-11-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ISOPROPYL PCA

This page reproduces the CosIng inventory entry for ISOPROPYL PCA from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ISOPROPYL PCA and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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