What function does POLYGLYCERYL-2 TETRAISOSTEARATE serve in cosmetics?

According to the EU CosIng inventory, POLYGLYCERYL-2 TETRAISOSTEARATE carries the following function designation(s): EMULSION STABILISING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - CLEANSING.

What other records share CAS 121440-30-0?

CAS 121440-30-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains POLYGLYCERYL-2 TETRAISOSTEARATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8250715/10/2010

POLYGLYCERYL-2 TETRAISOSTEARATE

Polyglyceryl-2 tetraisostearate consist of 1,2,3-Propanetriol, homopolymer, isooctadecanoates (1:4) (2 mol glycerol average molar ratio)

POLYGLYCERYL-2 TETRAISOSTEARATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 121440-30-0

CAS 121440-30-0PubChem CID 102523418

Polyglyceryl-2 Tetraisostearate

The CIR Expert Panel concluded that the 274 polyglyceryl fatty acid esters listed below are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating..Polyglyceryl-2 Tetraisostearate... — Cosmetic Ingredient Review (CIR)

IUPAC name: [3-[2,3-bis(16-methylheptadecanoyloxy)propoxy]-2-(16-methylheptadecanoyloxy)propyl] 16-methylheptadecanoate

Molecular formula: C78H150O9
Molecular weight: 1232.0 g/mol
Exact mass: 1231.12798636 Da
XLogP3: 32.3
Topological polar surface area: 114.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 9
Covalent units: 1
Defined stereocentres: 0

Also known as

Cithrol PG24ISSalacos 44VCosmol 44VKN8R167SEQS-FACE IS-204 PUNII-KN8R167SEQRefChem:175154PVQZOFSIXYDDHY-UHFFFAOYSA-N

Open full PubChem record PubChem annotations 3D structure image

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match102523418

Attributed physical-property, hazard, environmental and use annotations.

Note: This chemical does not meet GHS hazard criteria for 100% (8 of 8) of all reports. Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 8 of 8 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 8 reports by companies from 1 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 8 of 8 reports by companies.; There are 0 notifications provided by 0 of 8 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concluded that the 274 polyglyceryl fatty acid esters listed below are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating..Polyglyceryl-2 Tetraisostearate... Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)

Cosmetic Ingredient Review Link: CIR ingredient: Polyglyceryl-2 Tetraisostearate Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for POLYGLYCERYL-2 TETRAISOSTEARATE

INCI name

POLYGLYCERYL-2 TETRAISOSTEARATE

Description

Polyglyceryl-2 tetraisostearate consist of 1,2,3-Propanetriol, homopolymer, isooctadecanoates (1:4) (2 mol glycerol average molar ratio)

Record provenance

Inventory reference: 82507
Imported identity: POLYGLYCERYL-2 TETRAISOSTEARATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for POLYGLYCERYL-2 TETRAISOSTEARATE

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching POLYGLYCERYL-2 TETRAISOSTEARATE or related substances.

Key data

CAS

121440-30-0

—

Restriction

—

Function

EMULSION STABILISING: Helping the process of emulsification and improving emulsion stability and shelf-life.
SKIN CONDITIONING: Maintaining the skin in good condition.
SKIN CONDITIONING - EMOLLIENT: Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.
SURFACTANT - CLEANSING: Wetting body surfaces, emulsifying or solubilizing oils, and suspending soil (generally, such ingredients contribute to the foaming and lathering properties of cleansing products).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#21829 · POLYGLYCERYL-2 TETRAISOSTEARATE

Ingredients with overlapping formulation functions

POLYETHYLENE/ISOPROPYL MALEATE/MA COPOLYOLEMULSION STABILISING, VISCOSITY CONTROLLING

POLYGLYCERYL-10 HEPTACAPRYLATEEMULSION STABILISING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYI…

POLYGLYCERYL-2 DIISOSTEARATE/IPDI COPOLYMERBINDING, EMULSION STABILISING, FILM FORMING

POLYGLYCERYL-2 ISONONANOATE/DIMER DILINOLEATE COPOLYMERBINDING, EMULSION STABILISING, HAIR CONDITIONING, SKIN CONDITIONING

POLYGLYCERYL-20 LAURYL ETHERCLEANSING, EMULSION STABILISING, LIGHT STABILIZER, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING…

POLYGLYCERYL-3 BEHENATEEMULSION STABILISING

POLYGLYCERYL-3 SUNFLOWERSEEDATE/CITRATE CROSSPOLYMEREMULSION STABILISING, SURFACTANT - CLEANSING

POLYGLYCERYL-35 LAURYL ETHEREMULSION STABILISING, SURFACTANT - CLEANSING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How POLYGLYCERYL-2 TETRAISOSTEARATE appears in the CosIng inventory

The CosIng inventory lists POLYGLYCERYL-2 TETRAISOSTEARATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

POLYGLYCERYL-2 TETRAISOSTEARATE is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

POLYGLYCERYL-2 TETRAISOSTEARATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, POLYGLYCERYL-2 TETRAISOSTEARATE carries the following function designation(s):

CAS 121440-30-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for POLYGLYCERYL-2 TETRAISOSTEARATE

This page reproduces the CosIng inventory entry for POLYGLYCERYL-2 TETRAISOSTEARATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research POLYGLYCERYL-2 TETRAISOSTEARATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect POLYGLYCERYL-2 TETRAISOSTEARATE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to POLYGLYCERYL-2 TETRAISOSTEARATE, its identifiers or nearby name variants.