Is TRIHEPTANOIN safe to use in EU cosmetics?

TRIHEPTANOIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does TRIHEPTANOIN serve in cosmetics?

According to the EU CosIng inventory, TRIHEPTANOIN carries the following function designation(s): SKIN CONDITIONING, SURFACTANT - CLEANSING, VISCOSITY CONTROLLING.

What other records share CAS 620-67-7?

CAS 620-67-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains TRIHEPTANOIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8035915/10/2010

TRIHEPTANOIN

Propane-1,2,3-triyl trisheptanoate

TRIHEPTANOIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 620-67-7

CAS 620-67-7PubChem CID 69286

Triheptanoin

Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation. In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, rhabdomyolysis, and hepatomegaly. Complications in lc-FAOD patients are reduced from approximately 60% to approximately 10% with the addition of triheptanoin. Triheptanoin was granted FDA approval on 30 June 2020. — DrugBank

IUPAC name: 2,3-di(heptanoyloxy)propyl heptanoate

Molecular formula: C24H44O6
Molecular weight: 428.6 g/mol
Exact mass: 428.31378912 Da
XLogP3: 7.3
Topological polar surface area: 78.9 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

TrienanthoinTrioenanthoinTriheptylinGlycerol triheptanoateHeptanoin, tri-Triheptanoic glycerideDermofeel TC 7Dojolvi

16 more reported names

GLYCERYL TRIHEPTANOATEglyceroltriheptanoateUX007Dub thgDermofeel tc-7Radiamuls 2375Lanol 37 ttriheptanoinatriheptanoineHeptanoic acid, 1,2,3-propanetriyl ester2P6O7CFW5KUX-007Heptanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester1,3-bis(heptanoyloxy)propan-2-yl heptanoatetriheptanoinumRefChem:57618

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL4297585
EPA DTXSID:DTXSID40862306
PubMed:32897506
PubMed:22509165
PubMed:22260920
PubMed:22084831
PubMed:21855298
PubMed:21382692
PubMed:20857067
PubMed:20830526
PubMed:20691264
PubMed:20655781
PubMed:20589068
PubMed:20512158

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TRIHEPTANOIN

INCI name

TRIHEPTANOIN

Description

Propane-1,2,3-triyl trisheptanoate

Record provenance

Inventory reference: 80359
Imported identity: TRIHEPTANOIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TRIHEPTANOIN

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Key data

CAS

620-67-7

210-647-2

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.
SURFACTANT - CLEANSING: Wetting body surfaces, emulsifying or solubilizing oils, and suspending soil (generally, such ingredients contribute to the foaming and lathering properties of cleansing products).
VISCOSITY CONTROLLING: Increasing or decreasing the viscosity (thickness) of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29216 · TRIHEPTANOIN

Ingredients with overlapping formulation functions

TRIFLUOROPROPYL DIMETHICONE/PEG-10 CROSSPOLYMERSKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING, VISCOSITY CONTROLLING

TRIFLUOROPROPYL DIMETHICONE/TRIFLUOROPROPYL DIVINYLDIMETHICONE CROSSPOLYMERSKIN CONDITIONING, SURFACTANT - CLEANSING, VISCOSITY CONTROLLING

TRIFLUOROPROPYL DIMETHICONE/VINYL TRIFLUOROPROPYL DIMETHICONE/SILSESQUIOXANE CR…VISCOSITY CONTROLLING

TRIGONELLA FOENUM-GRAECUM SEED POWDERVISCOSITY CONTROLLING

TRIHEPTYLUNDECANOINREFATTING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, VISCOSITY CONTROLLING

TRIHYDROXYSTEARINSKIN CONDITIONING, VISCOSITY CONTROLLING

TRIISONONANOINSKIN CONDITIONING, VISCOSITY CONTROLLING

TRIISOPALMITINSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, VISCOSITY CONTROLLING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TRIHEPTANOIN appears in the CosIng inventory

The CosIng inventory lists TRIHEPTANOIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TRIHEPTANOIN is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TRIHEPTANOIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TRIHEPTANOIN carries the following function designation(s):

CAS 620-67-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for TRIHEPTANOIN

This page reproduces the CosIng inventory entry for TRIHEPTANOIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TRIHEPTANOIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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