What other records share CAS 1197-18-8?

CAS 1197-18-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 8029115/10/2010

TRANEXAMIC ACID

Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-

TRANEXAMIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Source mapped Inventory entry; no linked annex rule	0	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Evidence linked Restricted Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Evidence linked Restricted Open this evidence	1	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 1197-18-8

CAS 1197-18-8PubChem CID 5526

4-(Aminomethyl)cyclohexanecarboxylic acid

Tranexamic acid is a monocarboxylic acid. It has a role as an antifibrinolytic drug and a hematologic agent. It is functionally related to a cyclohexanecarboxylic acid. — ChEBI

IUPAC name: 4-(aminomethyl)cyclohexane-1-carboxylic acid

Molecular formula: C8H15NO2
Molecular weight: 157.21 g/mol
Exact mass: 157.110278721 Da
XLogP3: -2.0
Topological polar surface area: 63.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

701-54-2Cyclohexanecarboxylic acid, 4-(aminomethyl)-4-(Aminomethyl)-Cyclohexanecarboxylic AcidRefChem:1070026622-133-9tranexamic acid1197-17-7trans-4-(Aminomethyl)cyclohexanecarboxylic acid

16 more reported names

CyklokapronTrans AMCHACyclocapronTransaminAmstatTranhexamic acidTranexamsaeureRikavarintrans-AmchaAmikapronAnvitoffcis-Tranexamic AcidUgurolcis-4-(Aminomethyl)cyclohexanecarboxylic acidFrenolyseTranexan

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:48669
ChEBI:CHEBI:94518
ChEMBL:CHEMBL292500
ChEMBL:CHEMBL877
EPA DTXSID:DTXSID3045350
EPA DTXSID:DTXSID50904827
PubMed:23114797
PubMed:23100384
PubMed:23074629
PubMed:23074365
PubMed:23045310
PubMed:23022837
PubMed:22975817
PubMed:22968981
PubMed:22968722
PubMed:22968527
PubMed:22959314
PubMed:22956886

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match5526

Attributed physical-property, hazard, environmental and use annotations.

Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TRANEXAMIC ACID

INCI name

TRANEXAMIC ACID

Description

Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-

Record provenance

Inventory reference: 80291
Imported identity: TRANEXAMIC ACID
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TRANEXAMIC ACID

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Key data

CAS

1197-18-8

214-818-2

Restriction

—

Function

ASTRINGENT: Contracting and/or tightening the skin.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28997 · TRANEXAMIC ACID

Ingredients with overlapping formulation functions

THUJA ORIENTALIS EXTRACTANTIMICROBIAL, ASTRINGENT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

TIOXOLONEASTRINGENT

TORILIS JAPONICA EXTRACTANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, SKIN CONDITIONING - EMOLLIENT

TORILIS JAPONICA SEED EXTRACTANTIMICROBIAL, ASTRINGENT, SKIN CONDITIONING

TRIFOLIUM PRATENSE FLOWER EXTRACTASTRINGENT, FRAGRANCE

TRIPEPTIDE-51ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

TRIS-METHYLGLUCAMMONIUM CHLORIN E6ANTI-SEBUM; ASTRINGENT

TUSSILAGO FARFARA FLOWER EXTRACTASTRINGENT, SKIN CONDITIONING - EMOLLIENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TRANEXAMIC ACID appears in the CosIng inventory

The CosIng inventory lists TRANEXAMIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TRANEXAMIC ACID is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TRANEXAMIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TRANEXAMIC ACID carries the following function designation(s):

CAS 1197-18-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TRANEXAMIC ACID

This page reproduces the CosIng inventory entry for TRANEXAMIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TRANEXAMIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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