NISIN
Nisin is a polypeptide produced by the fermentation of Lactococcus lactis
NISIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
Nisin
Nisaplin has been reported in Lactococcus lactis with data available. — LOTUS - the natural products occurrence database
- IUPAC name
- 6-amino-2-[2-[[2-[[2-[[2-[[2-[[7-[[6-amino-2-[[2-[[4-amino-2-[[21-[[6-amino-2-[[3-[[15-[[(Z)-2-[(2-amino-3-methylpentanoyl)amino]but-2-enoyl]amino]-12-butan-2-yl-9-methylidene-6-(2-methylpropyl)-5,8,11,14-tetraoxo-1-thia-4,7,10,13-tetrazacyclohexadecane-3-carbonyl]amino]-4-methyl-2,9,12-trioxo-5-thia-1,8,11-triazabicyclo[11.3.0]hexadecane-7-carbonyl]amino]hexanoyl]amino]-15,22-dimethyl-12-(2-methylpropyl)-9-(2-methylsulfanylethyl)-5,8,11,14,17,20-hexaoxo-1-thia-4,7,10,13,16,19-hexazacyclodocosane-3-carbonyl]amino]-4-oxobutanoyl]amino]-4-methylsulfanylbutanoyl]amino]hexanoyl]amino]-14-(1H-imidazol-5-ylmethyl)-4,8,20-trimethyl-3,6,12,15,21-pentaoxo-9,19-dithia-2,5,13,16,22-pentazabicyclo[9.9.2]docosane-17-carbonyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutanoyl]amino]prop-2-enoylamino]hexanoic acid
- Molecular formula
- C143H230N42O37S7
- Molecular weight
- 3354.1 g/mol
- Exact mass
- 3352.5485595 Da
- XLogP3
- -6.1
- Topological polar surface area
- 1390.0 Ų
- Hydrogen-bond donors
- 41
- Hydrogen-bond acceptors
- 50
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
10 more reported names
External database identifiers
- PubMed:36084725
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for NISIN
INCI name
NISIN
Description
Nisin is a polypeptide produced by the fermentation of Lactococcus lactis
Record provenance
- Inventory reference
- 77427
- Imported identity
- NISIN
- Source update
- 15/10/2010
Annex records for NISIN
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How NISIN appears in the CosIng inventory
The CosIng inventory lists NISIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
NISIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for NISIN
This page reproduces the CosIng inventory entry for NISIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research NISIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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