Is CAPSAICIN safe to use in EU cosmetics?

CAPSAICIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 404-86-4?

CAS 404-86-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CAPSAICIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 7486415/10/2010

CAPSAICIN

N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

CAPSAICIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 404-86-4

CAS 404-86-4PubChem CID 1548943

Capsaicin

Capsaicin is a capsaicinoid. It has a role as a TRPV1 agonist, a non-narcotic analgesic and a voltage-gated sodium channel blocker. — ChEBI

IUPAC name: (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

Molecular formula: C18H27NO3
Molecular weight: 305.4 g/mol
Exact mass: 305.19909372 Da
XLogP3: 3.6
Topological polar surface area: 58.6 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

ZostrixCAPSAICINEtrans-CapsaicinQutenzaStyptysatAxsainAusanilIsodecenoic acid vanillylamide

16 more reported names

trans-8-Methyl-N-vanillyl-6-nonenamideMiotonNGX-4010DolenonOvocap(E)-8-Methyl-N-vanillyl-6-nonenamideFEMA No. 3404Capzasin-hp8-Methyl-N-Vanillyl-6-NonenamideTogarashi orenjiALGRX 4975Ratden pe 40NCI-C56564NGX 4010Capsaicina(E)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3374
ChEBI:CHEBI:94524
ChEMBL:CHEMBL294199
EPA DTXSID:DTXSID9020241
PubMed:39800145
PubMed:36925032
PubMed:36744297
PubMed:36044967
PubMed:34939720
PubMed:33512557
PubMed:31857126
PubMed:31653969
PubMed:31096838
PubMed:30636360
PubMed:30424709
PubMed:30342015

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CAPSAICIN

INCI name

CAPSAICIN

INN name

Capsaicin [USAN]

Description

N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

Record provenance

Inventory reference: 74864
Imported identity: CAPSAICIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CAPSAICIN

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching CAPSAICIN or related substances.

Key data

CAS

404-86-4

206-969-8

Restriction

—

Function

FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#5420 · CAPSAICIN

Ingredients with overlapping formulation functions

CAPRYLIC ACIDCLEANSING, FRAGRANCE, PERFUMING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

CAPRYLIC/CAPRIC TRIGLYCERIDEFRAGRANCE, PERFUMING, SKIN CONDITIONING

CAPRYLYL ALCOHOLFRAGRANCE, PERFUMING

CAPRYLYL BUTYRATEFRAGRANCE, PERFUMING, SKIN CONDITIONING

CAPSICUM ANNUUM EXTRACTFRAGRANCE, SKIN CONDITIONING, TONIC

CAPSICUM FRUTESCENS RESINCLEANSING, FRAGRANCE, TONIC

CARAMELCOLORANT, FRAGRANCE

CARTHAMUS TINCTORIUS FLOWERFRAGRANCE

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CAPSAICIN appears in the CosIng inventory

The CosIng inventory lists CAPSAICIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CAPSAICIN is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CAPSAICIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CAPSAICIN carries the following function designation(s):

CAS 404-86-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for CAPSAICIN

This page reproduces the CosIng inventory entry for CAPSAICIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CAPSAICIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect CAPSAICIN and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to CAPSAICIN, its identifiers or nearby name variants.